Comprehensive review of targeted therapy for colorectal cancer

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 20, 2020

Abstract Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in world was responsible for nearly 881,000 cancer-related deaths 2018. Surgery chemotherapy have long been first choices patients. However, prognosis of CRC has never satisfying, especially patients with metastatic lesions. Targeted therapy a new optional approach that successfully prolonged overall survival Following successes anti-EGFR (epidermal growth factor receptor) agent cetuximab anti-angiogenesis bevacizumab, agents blocking different critical pathways as well immune checkpoints are emerging at an unprecedented rate. Guidelines worldwide currently updating recommended targeted drugs on basis increasing number high-quality clinical trials. This review provides overview existing CRC-targeted their underlying mechanisms, discussion limitations future trends.

Language: Английский

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A Review of Colorectal Cancer in Terms of Epidemiology, Risk Factors, Development, Symptoms and Diagnosis

Cancers, Journal Year: 2021, Volume and Issue: 13(9), P. 2025 - 2025

Published: April 22, 2021

This review article contains a concise consideration of genetic and environmental risk factors for colorectal cancer. Known associated with cancer include familial hereditary lifestyle-related ecological factors. Lifestyle are significant because the potential improving our understanding disease. Physical inactivity, obesity, smoking alcohol consumption can also be addressed through therapeutic interventions. We made efforts to systematize available literature data on epidemiology, diagnosis, type nature symptoms disease stages. Further study progress globally is crucial inform future strategies in controlling disease’s burden population-based preventative initiatives.

Language: Английский

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Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies

Cancers, Journal Year: 2022, Volume and Issue: 14(7), P. 1732 - 1732

Published: March 29, 2022

Colorectal cancer (CRC) is the second most deadly cancer. Global incidence and mortality are likely to be increased in coming decades. Although deaths associated with CRC very high high-income countries, fatalities related growing developing countries too. detected early entirely curable by surgery subsequent medications. However, recurrence rate high, drug resistance increases treatment failure rate. Access diagnosis of for survival somewhat possible developed countries. these facilities rarely available Highlighting current status CRC, its development, risk factors, management crucial creating public awareness. Therefore, this review, we have comprehensively discussed global epidemiology, resistance, challenges, preventive strategies CRC. Additionally, there a brief discussion on development pathways recommendations preventing treating

Language: Английский

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Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota

Nutrients, Journal Year: 2023, Volume and Issue: 15(9), P. 2211 - 2211

Published: May 6, 2023

Short-chain fatty acids (SCFAs) play a key role in health and disease, as they regulate gut homeostasis their deficiency is involved the pathogenesis of several disorders, including inflammatory bowel diseases, colorectal cancer, cardiometabolic disorders. SCFAs are metabolites specific bacterial taxa human microbiota, production influenced by foods or food supplements, mainly prebiotics, direct fostering these taxa. This Review provides an overview SCFAs’ roles functions, SCFA-producing bacteria, from microbiological characteristics taxonomy to biochemical process that lead release SCFAs. Moreover, we will describe potential therapeutic approaches boost levels treat different related diseases.

Language: Английский

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The Intestinal Microbiota and Colorectal Cancer

Frontiers in Immunology, Journal Year: 2020, Volume and Issue: 11

Published: Nov. 30, 2020

The intestinal microbiota, composed of a large population microorganisms, is often considered "forgotten organ" in human health and diseases. Increasing evidence indicates that dysbiosis the microbiota closely related to colorectal cancer (CRC). roles for microorganisms initiated facilitated CRC process are becoming increasingly clear. Hypothesis models have been proposed illustrate complex relationship between CRC. Recent studies identified Streptococcus bovis, enterotoxigenic Bacteroides fragilis, Fusobacterium nucleatum, Enterococcus faecalis, Escherichia coli, Peptostreptococcus anaerobius as candidate pathogens. In this review, we summarized mechanisms involved microbiota-related carcinogenesis, including inflammation, pathogenic bacteria, their virulence factors, genotoxins, oxidative stress, bacterial metabolites, biofilm. We also described clinical values novel strategies preventing treating

Language: Английский

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High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites

Gastroenterology, Journal Year: 2021, Volume and Issue: 162(1), P. 135 - 149.e2

Published: Aug. 27, 2021

Language: Английский

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Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: June 30, 2022

Colorectal cancer (CRC) is the second most deadly worldwide. CRC management challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs spices used in cooking, practised for generations, have been shown contain protective effect or even be useful as an anti-CRC adjuvant therapy when doses. many bioactive compounds possess beneficial health effects. The chemopreventive properties of these herbs are mainly mediated by BCL-2, K-ras, MMP pathways, caspase activation, extrinsic apoptotic pathway, regulation ER-stress-induced apoptosis. As a safer natural alternative, could good candidates chemotherapeutic agents because their antiproliferative action on colorectal carcinoma cells inhibitory activity angiogenesis. Therefore, this narrative review, six different herbs: ginger ( Zingiber officinale Roscoe), turmeric Curcuma longa L.), garlic Allium sativum fenugreek Trigonella foenum-graecum sesame Sesamum indicum flaxseed Linum usitatissimum L.) daily cuisine were selected study analyzed chemoprotective roles with underlying molecular mechanisms actions. Initially, comprehensively discussed basis development, followed culinary traditional uses, current scientific research, publications cancers. Lead each herb spice, including phytoconstituents, antioxidant activities, anti-inflammatory properties, finally, effects treatment mechanisms. Future possible works suggested where applicable.

Language: Английский

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Host–microbiota maladaptation in colorectal cancer

Nature, Journal Year: 2020, Volume and Issue: 585(7826), P. 509 - 517

Published: Sept. 23, 2020

Language: Английский

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Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon

Carbohydrate Polymers, Journal Year: 2021, Volume and Issue: 267, P. 118231 - 118231

Published: May 20, 2021

Language: Английский

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Gut microbiome and its role in colorectal cancer

BMC Cancer, Journal Year: 2021, Volume and Issue: 21(1)

Published: Dec. 11, 2021

Colorectal cancer (CRC) is still one of the most common types in world, and gut microbiome plays an important role its development. The involved carcinogenesis, formation progression CRC as well response to different systemic therapies. composition bacterial strains influence geography, race, sex, diet on serve information for screening, early detection prediction treatment outcome CRC.Microbiome modulation prospective new strategies medicine improve health individuals. Therefore, future research clinical trials oncology patients are warranted determine efficacy treatments CRC, minimize adverse effects increase survival rates.

Language: Английский

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