Roles of Short-Chain Fatty Acids in Inflammatory Bowel Disease

Nutrients, Journal Year: 2023, Volume and Issue: 15(20), P. 4466 - 4466

Published: Oct. 21, 2023

The gut microbiome is a diverse bacterial community in the human gastrointestinal tract that plays important roles variety of biological processes. Short-chain fatty acids (SCFA) are produced through fermentation dietary fiber. Certain microbes responsible for producing SCFAs such as acetate, propionate and butyrate. An imbalance diversity can lead to metabolic disorders inflammation-related diseases. Changes SCFA levels associated microbiota were observed IBD, suggesting an association between disease. affect reactive oxygen species (ROS) with IBD. Gut closely related it study them further.

Language: Английский

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The Role of the FODMAP Diet in IBS

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 370 - 370

Published: Jan. 26, 2024

The low FODMAP (fermentable oligosaccharide, disaccharide, monosaccharide, and polyol) diet is a beneficial therapeutic approach for patients with irritable bowel syndrome (IBS). However, how the works still not completely understood. These mechanisms encompass only traditionally known factors such as luminal distension induced by gas water but also recent evidence on role of FOMAPs in modulation visceral hypersensitivity, increases intestinal permeability, induction microbiota changes, production short-chain fatty acids (SCFAs), well metabolomics alterations motility. Although most supporting quality, trials have confirmed its effectiveness, even though majority pertains to restriction phase effectiveness relieving abdominal bloating pain. This review examines potential pathophysiological provides an overview existing across various IBS subtypes. Key considerations use include challenges disadvantages associated practical implementation, including need professional guidance, variations individual responses, concerns related microbiota, nutritional deficiencies, development constipation, necessity excluding eating disorder before commencing diet, scarcity long-term data. Despite recognized efficacy symptom management, acknowledging these limitations becomes imperative nuanced comprehension managing IBS. By investigating subtypes addressing emerging modulations alongside limitations, this aims serve valuable resource healthcare practitioners, researchers, navigating intricate landscape

Language: Английский

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The Role of Diet and Nutritional Interventions for the Infant Gut Microbiome

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 400 - 400

Published: Jan. 30, 2024

The infant gut microbiome plays a key role in the healthy development of human organism and appears to be influenced by dietary practices through multiple pathways. First, maternal diet during pregnancy nutrition significantly influence microbiota. Moreover, breastfeeding fosters proliferation beneficial bacteria, while formula feeding increases microbial diversity. timing introducing solid foods also influences microbiota composition. In preterm infants is factors, including time since birth intake breast milk, interventions such as probiotics prebiotics supplementation show promising results reducing morbidity mortality this population. These findings underscore need for future research understand long-term health impacts these further strategies enrich formula-fed infants.

Language: Английский

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Micro(nano)plastics and Their Potential Impact on Human Gut Health: A Narrative Review

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(3), P. 2658 - 2677

Published: March 21, 2024

Microplastics and nanoplastics (MNPs) are becoming an increasingly severe global problem due to their widespread distribution complex impact on living organisms. Apart from environmental impact, the effects of MNPs organisms have also continued attract attention. The harmful has been extensively documented in marine invertebrates larger vertebrates like fish. However, research toxicity these particles mammals is still limited, possible humans poorly understood. Considering that commonly found food or packaging, primarily exposed them through ingestion. It would be valuable investigate potential gut health. This review focuses recent exploring toxicological impacts micro- gut, as observed human cell lines mammalian models. Available data various studies indicate accumulation models cells may result adverse consequences, terms epithelial toxicity, immune disruption microbiota. paper discusses current limitations prospects this field, aiming provide a scientific basis reference for further toxic mechanisms nanoplastics.

Language: Английский

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A Comprehensive Review of the Triangular Relationship among Diet–Gut Microbiota–Inflammation

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9366 - 9366

Published: Aug. 29, 2024

The human gastrointestinal tract hosts a complex and dynamic community of microorganisms known as the gut microbiota, which play pivotal role in numerous physiological processes, including digestion, metabolism, immune function. Recent research has highlighted significant impact diet on microbiota composition functionality, consequential effects host health. Concurrently, there is growing evidence linking to inflammation, key factor many chronic diseases such inflammatory bowel disease (IBD), obesity, diabetes, cardiovascular (CVDs). This review explores how dietary components influence composition, these microbial changes affect pathways, therapeutic implications modulating this axis for prevention management. Beneficial patterns, Mediterranean (MD) plant-based diets, promote diverse balanced supporting anti-inflammatory pathways. Conversely, Western (WD), high saturated fats refined sugars, associated with dysbiosis increased inflammation. With all links between three variables considered, attempts offer thorough examination triangle formed by food.

Language: Английский

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Health benefits and health risks of contaminated fish consumption: Current research outputs, research approaches, and perspectives

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33905 - e33905

Published: July 1, 2024

BackgroundFish contains high-quality omega-3 fatty acids, protein, vitamins, and minerals due to this it is termed as an essential component of a balanced diet. But there have been concerns raised about the risks consuming fish that contaminated with toxins such methylmercury, polychlorinated biphenyls (PCBs), dioxins, pesticides, plastic waste. Consumption containing these pollutants raising global mortality morbidity rates.Scope approachesThe review examines current research outputs on health benefits potential consumption. The also discusses various approaches mitigating problems caused by consumption, highlights roles balancing when fish.Key findings conclusionDifferent indicated contaminants cause cancer, kidney failure, adverse neurological effect, cardiovascular diseases, so vulnerable groups pregnant, child breast-feeding children. In conclusion, need get more tangible evidence advantages disadvantages consumption safeguard wellbeing society.

Language: Английский

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Bacteria-derived short-chain fatty acids as potential regulators of fungal commensalism and pathogenesis

Trends in Microbiology, Journal Year: 2024, Volume and Issue: 32(11), P. 1106 - 1118

Published: May 9, 2024

The human gastrointestinal microbiome encompasses bacteria, fungi, and viruses forming complex bionetworks which, for organismal health, must be in a state of homeostasis. An important homeostatic mechanism derives from microbial competition, which maintains the relative abundance species healthy balance. Microbes compete nutrients secrete metabolites that inhibit other microbes. Short-chain fatty acids (SCFAs) are one such class made by gut bacteria to very high levels. SCFAs metabolised microbes host cells have multiple roles regulating cell physiology. Here, we review mechanisms regulate fungal commensal Candida albicans. We discuss SCFA's ability growth, limit invasive behaviours modulate surface antigens recognised immune cells. underlying these roles: regulation gene expression, metabolism, signalling SCFA-driven post-translational protein modifications acylation, contribute changes acylome dynamics C. albicans with potentially large consequences Given mycobiome is reservoir systemic disease has also been implicated inflammatory bowel disease, understanding bacterial metabolites, as SCFAs, control might provide therapeutic avenues.

Language: Английский

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Probiotics and Food Bioactives: Unraveling Their Impact on Gut Microbiome, Inflammation, and Metabolic Health

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

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A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

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Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine

Gastrointestinal Disorders, Journal Year: 2025, Volume and Issue: 7(1), P. 7 - 7

Published: Jan. 15, 2025

The human microbiome, a complex ecosystem of microorganisms residing in and on the body, plays pivotal role regulation wide range physiological processes, including digestion, immune responses, metabolic functions. In recent years, rapidly growing field microbiome-driven therapeutics has garnered significant attention owing to its potential revolutionize healthcare. This review explores evolving landscape microbiome-based therapies, with particular focus gut microbiome implications for both health precision medicine. We highlight advances understanding how microbial communities influence disease pathogenesis treatment outcomes, spanning conditions such as inflammatory bowel (IBD), disorders, neurological diseases, even cancer. article also discusses emerging therapeutic strategies, probiotics, prebiotics, fecal microbiota transplantation (FMT), microbial-based drugs, well challenges associated their clinical implementation. Additionally, we examined integration profiling metagenomic data is advancing medicine, paving way personalized effective treatments. serves comprehensive resource that synthesizes current knowledge, identifies key gaps research, offers insights into future direction therapeutics, thus providing valuable framework clinicians, researchers, policymakers seeking harness microbiomes advance healthcare solutions.

Language: Английский

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