Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: April 23, 2024
The
gut
microbiota
modulates
response
to
hormonal
treatments
in
prostate
cancer
(PCa)
patients,
but
whether
it
influences
PCa
progression
remains
unknown.
Here,
we
show
a
reduction
fecal
alpha-diversity
correlating
with
increase
tumour
burden
two
distinct
groups
of
hormonotherapy
naïve
patients
and
three
murine
models.
Fecal
transplantation
(FMT)
from
high
volume
is
sufficient
stimulate
the
growth
mouse
revealing
existence
microbiome-cancer
crosstalk.
Analysis
microbial-related
pathways
mice
aggressive
identifies
enzymes
responsible
for
metabolism
long-chain
fatty
acids
(LCFA).
Supplementation
LCFA
omega-3
MAG-EPA
reduce
up-grading
pre-prostatectomy
Ruminococcaceae
both
butyrate
levels
patients.
This
suggests
that
beneficial
effect
rich
diet
mediated
part
by
modulating
crosstalk
between
microbes
their
metabolites
men
PCa.
Antibiotics,
Journal Year:
2023,
Volume and Issue:
12(2), P. 328 - 328
Published: Feb. 4, 2023
Most
bacteria
attach
to
biotic
or
abiotic
surfaces
and
are
embedded
in
a
complex
matrix
which
is
known
as
biofilm.
Biofilm
formation
especially
worrisome
clinical
settings
it
hinders
the
treatment
of
infections
with
antibiotics
due
facilitated
acquisition
antibiotic
resistance
genes
(ARGs).
Environmental
now
considered
pivotal
for
driving
biofilm
formation,
biofilm-mediated
development
dissemination.
Several
studies
have
demonstrated
that
environmental
biofilms
can
be
hotspots
dissemination
ARGs.
These
encoded
on
mobile
genetic
elements
(MGEs)
such
conjugative
mobilizable
plasmids
integrative
(ICEs).
ARGs
rapidly
transferred
through
horizontal
gene
transfer
(HGT)
has
been
shown
occur
more
frequently
than
planktonic
cultures.
models
promising
tools
mimic
natural
study
via
HGT.
This
review
summarizes
state-of-the-art
techniques
visualize
three
main
HGT
mechanisms
biofilms:
transformation,
transduction,
conjugation.
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(6), P. 766 - 766
Published: June 2, 2022
The
overuse
and
misuse
of
antibiotics
has
contributed
to
the
rise
spread
multidrug-resistant
bacteria.
To
address
this
global
public
health
threat,
many
countries
have
restricted
use
as
growth
promoters
promoted
development
alternatives
in
human
veterinary
medicine
animal
farming.
In
food-animal
production,
acidifiers,
bacteriophages,
enzymes,
phytochemicals,
probiotics,
prebiotics,
antimicrobial
peptides
shown
hallmarks
antibiotics.
This
review
reports
current
state
these
growth-promoting
factors
for
poultry
swine
production
describes
their
mode
action.
Recent
findings
on
usefulness
that
presently
hinder
broader
food
are
identified
by
SWOT
(strength,
weakness,
opportunity,
threat)
analysis.
potential
resistance
well
co-
cross-resistance
with
currently
used
is
also
discussed.
Using
predetermined
keywords,
we
searched
specialized
databases
including
Scopus,
Web
Science,
Google
Scholar.
Antibiotic
cannot
be
stopped,
but
its
spreading
can
certainly
hindered
or
delayed
more
innovative
modes
action
a
wise
careful
antimicrobials
One
Health
approach.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 28, 2022
Due
to
the
continuous
rise
in
biofilm-related
infections,
biofilms
seriously
threaten
human
health.
The
formation
of
makes
conventional
antibiotics
ineffective
and
dampens
immune
clearance.
Therefore,
it
is
important
understand
mechanisms
biofilm
develop
novel
strategies
treat
more
effectively.
This
review
article
begins
with
an
introduction
various
clinical
scenarios
their
corresponding
therapy.
Established
models
used
research
are
then
summarized.
potential
targets
which
may
assist
development
new
for
combating
further
discussed.
technologies
developed
recently
prevention
treatment
including
antimicrobial
surface
coatings,
physical
removal
biofilms,
molecules,
delivery
agents
subsequently
presented.
Finally,
directions
future
studies
pointed
out.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(13), P. 10672 - 10672
Published: June 26, 2023
Endocrine
homeostasis
and
metabolic
diseases
have
been
the
subject
of
extensive
research
in
recent
years.
The
development
new
techniques
insights
has
led
to
a
deeper
understanding
mechanisms
underlying
these
conditions
opened
up
avenues
for
diagnosis
treatment.
In
this
review,
we
discussed
rise
diseases,
especially
Western
countries,
genetical,
psychological,
behavioral
basis
role
nutrition
physical
activity
single-cell
transcriptomics,
gut
microbiota,
epigenetics,
advanced
imaging
techniques,
cell-based
therapies
diseases.
Finally,
practical
applications
derived
from
information
are
made.
Cyborg and Bionic Systems,
Journal Year:
2024,
Volume and Issue:
5
Published: Jan. 1, 2024
Untethered
and
self-transformable
miniature
robots
are
capable
of
performing
reconfigurable
deformation
on-demand
locomotion,
which
aid
the
traversal
toward
various
lumens,
bring
revolutionary
changes
for
targeted
delivery
in
gastrointestinal
(GI)
tract.
However,
viscous
non-Newtonian
liquid
environment
plicae
gastricae
obstacles
severely
hamper
high-precision
actuation
payload
delivery.
Here,
we
developed
a
low-friction
soft
robot
by
assembly
densely
arranged
cone
structures
grafting
hydrophobic
monolayers.
The
magnetic
orientation
encoded
can
move
multiple
modes,
with
substantially
reduced
drag,
terrain
adaptability,
improved
motion
velocity
across
liquids.
Notably,
stiffness
be
reversibly
controlled
magnetically
induced
hardening,
enabling
on-site
scratching
destruction
antibiotic-ineradicable
polymeric
matrix
biofilms
low-frequency
field.
Furthermore,
magnetocaloric
effect
utilized
to
eradicate
bacteria
under
high-frequency
alternating
To
verify
potential
applications
inside
body,
clinical
imaging-guided
platforms
were
vision-based
control
robots.
show
their
high
perform
bacterial
infection
therapy
lumens
body.
