Human gastric microbiota analysis of refractory H. pylori infection DOI Creative Commons

Xianfeng Huang,

Daya Zhang, Da Li

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 7, 2024

Abstract H. pylori infection is gaining increasing attention, but detailed investigations into its impact on gastric microbiota remain limited. We collected mucosa samples from 47 individuals divided three groups: 1. Group HP: patients with initial positive (25 cases); 2. ck: -negative (14 3. DiffHP: refractory (8 cases). The were analyzed using 16S rDNA sequencing and functional prediction PICRUSt. HP showed differences in flora distribution function compared to ck, while DiffHP overlapped HP. abundances of Aeromonas piscicola , Shewanella algae Vibrio plantisponsor caviae Serratia marcescens parahaemolyticus Microbacterium lacticum Prevotella nigrescens significantly reduced both ck. shilonii was only Clostridium perfringens Paracoccus marinus increased DiffHP. LEfSe analysis revealed that enriched, whereas ck at the species level. In infection, exhibited enrichment various human diseases, organic systems, metabolic pathways (amino acid metabolism, carbohydrate transcription, replication repair, cell cycle pathways, apoptosis). Patients multiple failed eradication significant changes microbiota. An increase a decrease appears be characteristic infection.

Language: Английский

Quorum sensing-mediated microbial interactions: Mechanisms, applications, challenges and perspectives DOI Creative Commons

Xiangyong Zeng,

Yunman Zou,

Jia Zheng

et al.

Microbiological Research, Journal Year: 2023, Volume and Issue: 273, P. 127414 - 127414

Published: May 20, 2023

Language: Английский

Citations

72
An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease DOI
Fan Xi, Zhuangzhuang Zhang, Wenxia Gao

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(1), P. 229 - 244

Published: Dec. 19, 2023

Colonic epithelial damage and dysregulated immune response are crucial factors in the progression exacerbation of inflammatory bowel disease (IBD). Nanoenabled targeted drug delivery to inflamed intestinal mucosa has shown promise inducing maintaining colitis remission, while minimizing side effects. Inspired by excellent antioxidative anti-inflammatory efficacy naturally derived magnolol (Mag) gut homeostasis regulation microbiota-derived butyrate, we developed a pH/redox dual-responsive butyrate-rich polymer nanoparticle (PSBA) as an oral Mag system for combinational therapy IBD. PSBA showed high butyrate content 22% effectively encapsulated Mag. The Mag-loaded nanoparticles (PSBA@Mag) demonstrated colonic pH reduction-responsive release, ensuring efficient retention adhesion colon mice. PSBA@Mag not only normalized level reactive oxygen species effectors but also restored barrier function both ulcerative Crohn's mouse models. Importantly, promoted migration healing ability cells vitro vivo, sensitizing therapeutic animal Moreover, transcriptomics metabolism analyses revealed that mitigated inflammation suppressing production pro-inflammatory cytokines chemokines restoring lipid metabolism. Additionally, this nanomedicine modulated microbiota inhibiting pathogenic Proteus Escherichia-Shigella promoting proliferation beneficial probiotics, including Lachnoclostridium, Lachnospiraceae_NK4A136_group norank_f_Ruminococcaceae. Overall, our findings highlight potential butyrate-functionalized polymethacrylates versatile effective nanoplatforms repair combating IBD other gastrointestinal disorders.

Language: Английский

Citations

50
The role of gut microbiota in intestinal disease: from an oxidative stress perspective DOI Creative Commons

Yiqi Sun,

Xurui Wang,

Lei Li

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 14, 2024

Recent studies have indicated that gut microbiota-mediated oxidative stress is significantly associated with intestinal diseases such as colorectal cancer, ulcerative colitis, and Crohn’s disease. The level of reactive oxygen species (ROS) has been reported to increase when the microbiota dysregulated, especially several bacterial metabolites are present. Although healthy plays a vital role in defending against excessive stress, disease influenced by ROS, this process controlled immunological responses, DNA damage, inflammation. In review, we discuss relationship between from an perspective. addition, also provide summary most recent therapeutic approaches for preventing or treating modifying microbiota.

Language: Английский

Citations

40
The interaction between autophagy, Helicobacter pylori, and gut microbiota in gastric carcinogenesis DOI Creative Commons
Ali Nabavi-Rad, Abbas Yadegar, Amir Sadeghi

et al.

Trends in Microbiology, Journal Year: 2023, Volume and Issue: 31(10), P. 1024 - 1043

Published: April 27, 2023

Language: Английский

Citations

24
Inflammatory Bowel Disease: A Comprehensive Analysis of Molecular Bases, Predictive Biomarkers, Diagnostic Methods, and Therapeutic Options DOI Open Access
Eguzkiñe Díez-Martín, Leidi Hernández-Suárez, Carmen Muñoz‐Villafranca

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7062 - 7062

Published: June 27, 2024

In inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC), the immune system relentlessly attacks intestinal cells, causing recurrent tissue damage over lifetime of patients. The etiology IBD is complex multifactorial, involving environmental, microbiota, genetic, immunological factors that alter molecular basis organism. Among these, microbiota cells play pivotal roles; generates antigens recognized by antibodies, while autoantibodies target attack membrane, exacerbating inflammation damage. Given altered framework, analysis multiple biomarkers in patients proves exceedingly valuable for diagnosing prognosing IBD, including markers like C reactive protein fecal calprotectin. Upon detection classification patients, specific treatments are administered, ranging from conventional drugs to new biological therapies, antibodies neutralize molecules tumor necrosis factor (TNF) integrin. This review delves into targets, biomarkers, treatment options, monitoring techniques, and, ultimately, current challenges management.

Language: Английский

Citations

14
Efficacy of probiotics, prebiotics, and synbiotics on liver enzymes, lipid profiles, and inflammation in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons

Youwen Pan,

Yafang Yang,

Jiale Wu

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 22, 2024

There is a contradiction in the use of microbiota-therapies, including probiotics, prebiotics, and synbiotics, to improve condition patients with nonalcoholic fatty liver disease (NAFLD). The aim this review was evaluate effect microbiota-therapy on injury, inflammation, lipid levels individuals NAFLD. Using Pubmed, Embase, Cochrane Library, Web Science databases were searched for articles prebiotic, probiotic, or synbiotic treatment NAFLD up March 2024. Thirty-four studies involving 12,682 included. Meta-analysis indicated that supplementation significantly improved injury (hepatic fibrosis, SMD = -0.31; 95% CI: -0.53, -0.09; aspartate aminotransferase, -0.35; -0.55, -0.15; alanine -0.48; -0.71, -0.25; alkaline phosphatase, -0.81; -1.55, -0.08), profiles (triglycerides, -0.22; -0.43, -0.02), inflammatory factors (high-density lipoprotein, -0.47; -0.88, -0.06; tumour necrosis factor alpha, -0.86 -1.56, -0.56). Overall, had positive reducing enzymes, profiles, cytokines

Language: Английский

Citations

14
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights DOI
Fatemeh Taghizadeh Ghassab,

Fatemeh Shamlou Mahmoudi,

Reyhaneh Taheri Tinjani

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 350, P. 122748 - 122748

Published: June 5, 2024

Language: Английский

Citations

10
Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation DOI
Mengke Yao,

Junhan Cao,

Ping Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15725 - 15739

Published: July 8, 2024

Indole-3-lactic acid (ILA) has exhibited antimicrobial properties. However, its role in inhibiting

Language: Английский

Citations

9
Inter-organ metabolic interaction networks in non-alcoholic fatty liver disease DOI Creative Commons
Yuhong Fan, Siyao Zhang, Ye Wang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.

Language: Английский

Citations

1
Helicobacter pylori infection process: from the molecular world to clinical treatment DOI Creative Commons
MinKyung Yi,

S. Chen,

Xiaoping Yi

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

Helicobacter pylori is a gram-negative microaerophilic microorganism intricately associated with chronic gastrointestinal disorders and gastric cancer. H. can cause various upper digestive tract diseases, including gastritis, peptic ulcer, gastroesophageal reflux disease, The bacterium exhibits variety of pathogenic mechanisms, colonization, the expression virulence factors, development drug resistance. This article presents comprehensive review pathogenesis, emphasizing recent research advancements concerning cytotoxin-associated gene A, vacuolating cytotoxin, outer membrane proteins, other factors. Additionally, it examines molecular mechanisms underlying resistance evaluates efficacy conventional therapeutic approaches. Recently, researchers have attempted novel regimens, probiotics Chinese medicine-assisted therapies, to enhance effects. aimed offer an overview academic community's comprehension infection highlight current treatment options.

Language: Английский

Citations

1