Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 30, 2022
Cuproptosis,
or
copper-induced
cell
death,
has
been
reported
as
a
novel
noncanonical
form
of
death
in
recent
times.
However,
the
potential
roles
cuproptosis
alteration
tumor
clinicopathological
features
and
formation
microenvironment
(TME)
remain
unclear.
In
this
study,
we
comprehensively
analyzed
cuproptosis-related
molecular
patterns
1,274
colorectal
cancer
samples
based
on
16
regulators.
The
consensus
clustering
algorithm
was
conducted
to
identify
gene
signatures.
ssGSEA
ESTIMATE
algorithms
were
used
evaluate
enrichment
levels
infiltrated
immune
cells
scores,
respectively.
score
established
assess
individuals
with
principal
component
analysis
expression
genes.
Three
distinct
confirmed
demonstrated
be
associated
distinguishable
biological
processes
clinical
prognosis.
Interestingly,
three
revealed
consistent
infiltration
characterizations:
immune-desert,
immune-inflamed,
immune-excluded.
Enhanced
survival,
activation
cells,
high
purity
presented
patients
low
cuproptosisScore,
implicating
immune-inflamed
phenotype.
addition,
scores
linked
mutation
burden,
MSI-H
CTLA4
expression,
showing
higher
proportion
(IPS).
Taken
together,
our
study
pattern
TME
cuproptosisScore
will
further
strengthen
understanding
feature
instruct
more
personalized
immunotherapy
schedule
cancer.
ACS Applied Materials & Interfaces,
Journal Year:
2022,
Volume and Issue:
15(1), P. 452 - 468
Published: Dec. 20, 2022
Pyroptosis,
as
a
novel
mode
of
cell
death,
has
been
proven
to
have
impressive
antitumor
effects.
Dying
cells
undergoing
pyroptosis
can
elicit
immunity
by
the
release
tumor-associated
antigens
(TAAs)
and
damage-associated
molecular
patterns
(DAMPs).
Accordingly,
developing
an
effective,
stable,
controllable
nanoplatform
that
promote
these
two
side
effects
is
promising
option
for
cancer
therapy.
In
this
study,
we
designed
carrier-free
chemo-photodynamic
(A-C/NPs)
using
co-assembly
strategy
with
cytarabine
(Ara-C)
chlorin
e6
(Ce6)
induce
subsequent
immune
response
against
breast
cancer.
Mechanistically,
A-C/NPs
trigger
GSDME-mediated
in
manner
through
reactive
oxygen
species
(ROS)
accumulation,
causing
immunogenic
death
(ICD),
which
dying
high-mobility
group
box
1
(HMGB1),
adenosine
triphosphate
(ATP),
calcitonin
(CRT).
Additionally,
Ara-C
stimulate
maturation
cytotoxic
T
lymphocytes
act
synergistically
Ce6-mediated
collectively
augmenting
anticancer
effect
A-C/NPs.
The
showed
excellent
suppressive
on
growth
orthotopic,
abscopal,
recurrent
tumors
mouse
model.
therapy
(PDT)
proposed
nanomedicine
could
be
triggering
improving
global
response.
Annals of Surgery,
Journal Year:
2022,
Volume and Issue:
276(3), P. 450 - 462
Published: June 27, 2022
Objective:
To
evaluate
if
patient-derived
organoids
(PDOs)
may
predict
response
to
neoadjuvant
(NAT)
chemotherapy
in
patients
with
pancreatic
adenocarcinoma.
Background:
PDOs
have
been
explored
as
a
biomarker
of
therapy
and
for
personalized
therapeutics
cancer.
Methods:
During
2017–2021,
were
enrolled
into
an
IRB-approved
protocol
PDO
cultures
established.
interest
analyzed
through
translational
pipeline
incorporating
molecular
profiling
drug
sensitivity
testing.
Results:
One
hundred
thirty-six
samples,
including
both
surgical
resections
fine
needle
aspiration/biopsy
from
117
cancer
collected.
This
biobank
included
diversity
stage,
sex,
age,
race,
minority
populations
representing
1/3
collected
cases
(16%
Black,
9%
Asian,
7%
Hispanic/Latino).
Among
specimens,
generation
was
successful
71%
(15
21)
who
had
received
NAT
prior
sample
collection
76%
(39
51)
untreated
or
radiation
at
the
time
collection.
Pathological
correlated
response,
particularly
oxaliplatin.
We
demonstrated
feasibility
rapid
screen
generated
data
within
7
days
tissue
resection.
Conclusion:
Herein
we
report
large
single-institution
organoid
biobank,
ethnic
samples.
The
ability
establish
chemotherapy-naive
post-NAT
enables
longitudinal
assess
dynamic
profiling.
can
be
rapidly
screened
further
development
screening
aid
initial
stratification
most
active
regimen.
Stem Cell Research & Therapy,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Jan. 29, 2022
Abstract
Due
to
the
overexpression
or
amplification
of
human
epidermal
growth
factor
receptor
2
(HER2)
with
poor
prognosis
in
a
myriad
tumors,
recent
studies
have
focused
on
HER2-targeted
therapies.
Deregulation
HER2
signaling
pathways
is
accompanied
by
sustained
tumor
cells
concomitant
their
migration
and
also
angiogenesis
metastasis
stimulation
proliferation
network
blood
vessels.
A
large
number
provided
clear
evidence
that
emerging
HER2-directed
treatments
could
be
outcome
patients
suffering
from
positive
breast
gastric/gastroesophageal
cancers.
Thanks
its
great
anti-tumor
competence,
immunotherapy
using
HER2-specific
chimeric
antigen
(CAR)
expressing
immune
cell
has
recently
attracted
increasing
attention.
Human
T
natural
killer
(NK)
can
largely
found
microenvironment,
mainly
contributing
surveillance.
Such
properties
make
them
perfect
candidate
for
genetically
modification
express
constructed
CARs.
Herein,
we
will
describe
potential
targets
clarify
HER2-mediated
tumorigenesis
discuss
findings
respecting
CAR-expressing
(CAR
CAR
NK
cell)
treatment
HER2-expressing
tumors.
Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Oct. 8, 2022
Abstract
Pediatric
cancers
are
the
driving
cause
of
death
for
children
and
adolescents.
Due
to
safety
requirements
considerations,
treatment
strategies
drugs
pediatric
have
been
so
far
scarcely
studied.
It
is
well
known
that
tumor
cells
tend
progressively
evade
cell
pathways,
which
as
apoptosis
resistance,
one
hallmarks
cancer,
dominating
drug
resistance.
Recently,
treatments
targeting
nonapoptotic
drawn
great
attention.
Pyroptosis,
a
newly
specialized
form
death,
acts
critical
physiological
regulator
in
inflammatory
reaction,
development,
tissue
homeostasis
stress
response.
The
action
different
forms
pyroptosis
significance
therapy
cancers.
Pyroptosis
could
be
induced
consequently
modulate
tumorigenesis,
progression,
metastasis
if
treated
with
local
or
systemic
therapies.
However,
excessive
uncontrolled
might
lead
damage,
acute
inflammation,
even
cytokine
release
syndrome,
facilitates
progression
recurrence.
Herein,
we
aimed
describe
molecular
mechanisms
pyroptosis,
highlight
discuss
challenges
opportunities
activating
pathways
through
various
oncologic
therapies
multiple
neoplasms,
including
osteosarcoma,
neuroblastoma,
leukemia,
lymphoma,
brain
tumors.
Frontiers in Immunology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 30, 2022
Cuproptosis,
or
copper-induced
cell
death,
has
been
reported
as
a
novel
noncanonical
form
of
death
in
recent
times.
However,
the
potential
roles
cuproptosis
alteration
tumor
clinicopathological
features
and
formation
microenvironment
(TME)
remain
unclear.
In
this
study,
we
comprehensively
analyzed
cuproptosis-related
molecular
patterns
1,274
colorectal
cancer
samples
based
on
16
regulators.
The
consensus
clustering
algorithm
was
conducted
to
identify
gene
signatures.
ssGSEA
ESTIMATE
algorithms
were
used
evaluate
enrichment
levels
infiltrated
immune
cells
scores,
respectively.
score
established
assess
individuals
with
principal
component
analysis
expression
genes.
Three
distinct
confirmed
demonstrated
be
associated
distinguishable
biological
processes
clinical
prognosis.
Interestingly,
three
revealed
consistent
infiltration
characterizations:
immune-desert,
immune-inflamed,
immune-excluded.
Enhanced
survival,
activation
cells,
high
purity
presented
patients
low
cuproptosisScore,
implicating
immune-inflamed
phenotype.
addition,
scores
linked
mutation
burden,
MSI-H
CTLA4
expression,
showing
higher
proportion
(IPS).
Taken
together,
our
study
pattern
TME
cuproptosisScore
will
further
strengthen
understanding
feature
instruct
more
personalized
immunotherapy
schedule
cancer.
