Photothermal therapy combined with a STING agonist induces pyroptosis, and gasdermin D could be a new biomarker for guiding the treatment of pancreatic cancer DOI Creative Commons
Yanyan Hu,

Erpeng Qi,

C. Chris Yun

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

Although photothermal therapy (PTT) can induce antitumour immunity, the mechanisms underlying its effects in pancreatic cancer (PC) require further exploration. In this study, mechanism of action PTT and connection to pyroptosis as well therapeutic potential alone combination with STING agonists, were investigated. addition, a biomarker PC was found stratify patients who are suitable for PTT. We explored whether vitro evaluated efficacy immunity-inducing ability combined agonist (c-di-GMP) immune adjuvant vivo PC. also gasdermin D (GSDMD) expression tumour tissues investigated drug sensitivity patient-derived organoids (PDOs) differential GSDMD expression. Our study demonstrated that local induces via caspase-1/GSDMD pathway elicits immunity. exhibits better than while limiting distant metastasis, enhances response by promoting dendritic cell maturation, increasing frequency infiltrating T cells, converting macrophages from M2 M1 phenotype. we is highly expressed overexpression might suggest increased resistance chemotherapy benefits therapy. confirmed PDOs higher less sensitive chemotherapeutic agent (5-Fluorouracil) lower expression, making new identifying may benefit work, c-di-GMP used an treat first time, results provide clues development novel immunotherapies simultaneously suppress primary tumours metastases. has great selection individualized treatment modalities.

Language: Английский

Oxidative Stress, Inflammation, Gut Dysbiosis: What Can Polyphenols Do in Inflammatory Bowel Disease? DOI Creative Commons
Lei Li,

Peilan Peng,

Ning Ding

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 967 - 967

Published: April 20, 2023

Inflammatory bowel disease (IBD) is a long-term, progressive, and recurrent intestinal inflammatory disorder. The pathogenic mechanisms of IBD are multifaceted associated with oxidative stress, unbalanced gut microbiota, aberrant immune response. Indeed, stress can affect the progression development by regulating homeostasis microbiota Therefore, redox-targeted therapy promising treatment option for IBD. Recent evidence has verified that Chinese herbal medicine (CHM)-derived polyphenols, natural antioxidants, able to maintain redox equilibrium in tract prevent abnormal radical responses. Here, we provide comprehensive perspective implementing antioxidants as potential candidate medications. In addition, demonstrate novel technologies stratagems promoting antioxidative properties CHM-derived including delivery systems, chemical modifications, combination strategies.

Language: Английский

Citations

62
Nanotechnology-enabled sonodynamic therapy against malignant tumors DOI Creative Commons

Yunxi Huang,

Wenhao Ouyang,

Zijia Lai

et al.

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(8), P. 1974 - 1991

Published: Jan. 1, 2024

This review systematically describes and summarizes the application of nanotechnology-enabled sonodynamic therapy in malignant tumors.

Language: Английский

Citations

16
Biomaterials Elicit Pyroptosis Enhancing Cancer Immunotherapy DOI

Meng‐Jie Zhang,

Yuanyuan Wang,

Lin‐Lin Han

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(7)

Published: Nov. 5, 2023

Abstract Cancer immunotherapy has the potential to revolutionize treatment of malignant tumors, but its effectiveness is limited by low immune response rate and immune‐related adverse events. Pyroptosis, as an inflammatory programmed cell death type, triggers strong acute antitumor immunity, converting “cold” tumors “hot”. Particularly, biomaterials loading pyroptosis inducers targeting tumor microenvironment engineer pyroptosis, have achieved great progress in recent years. Herein, design strategy, mechanism pathway, role induce cancer are comprehensively reviewed. The present review focuses on application biomaterials‐induced immunotherapy, including nanogel, polymer prodrug, nanovesicle, mesoporous material. Additionally, synthesis a series stimuli‐responsive nanoplatforms, glutathione‐responsive, pH‐responsive, reactive oxygen species‐responsive, enzyme‐mimicking catalytic performance, described. Meanwhile, it augments multiple processes uptake, antigen presentation, T‐cell activation, expansion. Finally, perspectives pyroptosis‐mediated inflammation break through vascular basement membrane barrier achieving efficient volcanic penetration discussed. Artificial intelligence, multi‐omics analysis, anthropogenic animal models organoids presented, aiming provide guidance assistance for constructing effective controllable pyroptosis‐engineered improving immunotherapy.

Language: Английский

Citations

25
The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles DOI Creative Commons
Yixiang Hu, Ya Liu,

Lijuan Zong

et al.

Cell Death and Disease, Journal Year: 2023, Volume and Issue: 14(12)

Published: Dec. 16, 2023

Abstract Pyroptosis is a novel regulated cell death (RCD) mode associated with inflammation and innate immunity. Gasdermin E (GSDME), crucial component of the gasdermin (GSDM) family proteins, has ability to convert caspase-3-mediated apoptosis pyroptosis cancer cells activate anti-tumor Accumulating evidence indicates that GSDME methylation holds tremendous potential as biomarker for early detection, diagnosis, prognosis, treatment tumors. In fact, GSDME-mediated performs dual role in therapy. On one side, pyroptotic tumors caused by contributes inflammatory cytokines release, which transform tumor immune microenvironment (TIME) from ‘cold’ ‘hot’ state significantly improve immunotherapy. However, due expressed nearly all body tissues cells, it can exacerbate chemotherapy toxicity partially block response. How achieve balance between two sides research topic. Meanwhile, functions anti-programmed protein 1 (PD-1) therapy, antibody-drug conjugates (ADCs) chimeric antigen receptor T (CAR-T cells) therapy have not yet been fully understood, how clinical outcomes persists obscure. this review, we systematically summarize latest regarding molecular mechanisms discuss immunity its applications treatment.

Language: Английский

Citations

23
Herbal medicine and gut microbiota: exploring untapped therapeutic potential in neurodegenerative disease management DOI Creative Commons

Yueyue Guan,

Guo-hua Tang,

Lei Li

et al.

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(2), P. 146 - 164

Published: Jan. 15, 2024

Abstract The gut microbiota that exists in the human gastrointestinal tract is incredibly important for maintenance of general health as it contributes to multiple aspects host physiology. Recent research has revealed a dynamic connection between and central nervous system, can influence neurodegenerative diseases (NDs). Indeed, imbalances microbiota, or dysbiosis, play vital role pathogenesis progression diseases, particularly NDs. Herbal medicine been used centuries treat including These compounds help relieve symptoms delay NDs by improving intestinal barrier function, reducing neuroinflammation, modulating neurotransmitter production. Notably, herbal mitigate regulating microbiota. Therefore, an in-depth understanding potential mechanisms which regulates treatment explain from novel perspective propose therapeutic strategies In this review, we investigate neuroprotective effects medicine, focusing on its ability regulate restore homeostasis. We also highlight challenges future priorities integration modern medicine. As global population ages, access information becoming increasingly developing effective treatments these diseases.

Language: Английский

Citations

14
Mitochondrial‐Targeted CS@KET/P780 Nanoplatform for Site‐Specific Delivery and High‐Efficiency Cancer Immunotherapy in Hepatocellular Carcinoma DOI Creative Commons
Shanshan Liu, Hailong Tian, Hui Ming

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Hepatocellular carcinoma (HCC) is a form of malignancy with limited curative options available. To improve therapeutic outcomes, it imperative to develop novel, potent modalities. Ketoconazole (KET) has shown excellent efficacy against HCC by eliciting apoptosis. However, its water solubility hampers application in clinical treatment. Herein, mitochondria‐targeted chemo‐photodynamic nanoplatform, CS@KET/P780 NPs, designed using nanoprecipitation strategy integrating newly synthesized photosensitizer (P780) and chemotherapeutic agent KET coated chondroitin sulfate (CS) amplify therapy. In this CS confers tumor‐targeted subsequently pH‐responsive drug delivery behavior binding glycoprotein CD44, leading the release P780 KET. Mechanistically, following laser irradiation, targets destroys mitochondrial integrity, thus inducing apoptosis through enhancement reactive oxygen species (ROS) buildup. Meanwhile, KET‐induced synergistically enhances anticancer effect P780. addition, tumor cells undergoing can trigger immunogenic cell death (ICD) longer‐term antitumor response releasing tumor‐associated antigens (TAAs) damage‐associated molecular patterns (DAMPs), which together contribute improved outcomes HCC. Taken together, NPs bioavailability exhibit exerting chemophototherapy immunity.

Language: Английский

Citations

12
“Multi‐in‐One” Yolk‐Shell Structured Nanoplatform Inducing Pyroptosis and Antitumor Immune Response Through Cascade Reactions DOI
Yuying Wang, Shulan Li,

Xiao‐Yang Zhang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: Feb. 25, 2024

Abstract Pyroptosis, a new mode of regulatory cell death, holds promising prospect in tumor therapy. The occurrence pyroptosis can trigger the release damage‐associated molecular patterns (DAMPs) and activate antitumor immune response. Moreover, enhancing intracellular reactive oxygen species (ROS) generation effectively induce pyroptosis. Herein, an integrated nanoplatform (hCZAG) based on zeolitic imidazolate framework‐8 (ZIF‐8) with Cu 2+ Zn as active nodes glucose oxidase (GOx) loading is constructed to evoke GOx elevate hydrogen peroxide (H 2 O ) levels regulate unfavorable microenvironment (TME). be reduced + by endogenous overexpressed GSH both exert Fenton‐like activity promote ROS amplify oxidative stress. In addition, accumulation leads aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), thus resulting cuproptosis. Notably, outburst induced hCZAG activates Caspase‐1 proteins, cleavage gasdermin D (GSDMD), induces Pyroptosis further elicits adaptive response, leading immunogenic death (ICD). This study provides effective strategies for triggering pyroptosis‐mediated immunotherapy achieving improved therapeutic effects.

Language: Английский

Citations

12
A pH and glutathione-responsive carbon monoxide-driven nano-herb delivery system for enhanced immunotherapy in colorectal cancer DOI
Yang Chen, Hui Ming, Bowen Li

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 376, P. 659 - 677

Published: Oct. 28, 2024

Language: Английский

Citations

9
Dual-Coordinated atomically dispersed Pt nanozymes evoke efficient pyroptosis for cancer immunotherapy DOI
Jingqi Chen, Yanping Tang,

Lin Yan

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 483, P. 149312 - 149312

Published: Feb. 5, 2024

Language: Английский

Citations

8
The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment DOI Creative Commons
Mengyuan Li, Ping Jiang, Yuhan Yang

et al.

Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)

Published: Dec. 8, 2023

Abstract Pyroptosis, an inflammatory programmed cell death, distinguishes itself from apoptosis and necroptosis has drawn increasing attention. Recent studies have revealed a correlation between the expression levels of many pyroptosis-related genes both tumorigenesis progression. Despite advancements in cancer treatments such as surgery, radiotherapy, chemotherapy, immunotherapy, persistent hallmark enables malignant cells to elude death develop resistance therapy. findings indicate that pyroptosis can overcome amplify treatment-induced tumor death. Moreover, triggers antitumor immunity by releasing pro-inflammatory cytokines, augmenting macrophage phagocytosis, activating cytotoxic T natural killer cells. Additionally, it transforms “cold” tumors into “hot” tumors, thereby enhancing effects various treatments. Consequently, is intricately linked development holds promise effective strategy for boosting therapeutic efficacy. As principal executive protein pyroptosis, gasdermin family plays pivotal role influencing pyroptosis-associated outcomes serve regulatory target. This review provides comprehensive summary relationship members, discusses their roles progression immune microenvironment, analyses underlying strategies treatment based on pyroptotic

Language: Английский

Citations

20