Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106691 - 106691
Published: Jan. 29, 2025
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 23, 2024
Gouty arthritis (GA) is an inflammatory disease characterized by pain. The primary goal of current treatment strategies during GA flares remains the reduction inflammation and Research suggests that gut microbiota microbial metabolites contribute to modulation mechanism associated with GA, particularly through their effect on macrophage polarization. increasing understanding gut-joint axis emphasizes importance this interaction. objective review summarize existing research gut-immune-joint in aiming enhance intricate processes pathogenic pathways pain as documented published literature. refined comprehension may potentially future development analgesic drugs targeting microbes for GA.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.
Language: Английский
Citations
4
Environmental Pollution, Journal Year: 2024, Volume and Issue: 361, P. 124862 - 124862
Published: Aug. 30, 2024
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract The overactivated immune cells in the infectious lesion may lead to irreversible organ damages under severe infections. However, clinically used immunosuppressive anti‐inflammatory drugs will usually disturb homeostasis and conversely increase risk of Regulating balance between anti‐inflammation anti‐infection is thus critical treating certain diseases. Herein, considering that hydrogen peroxide (H 2 O ), myeloperoxidase (MPO), neutrophils are upregulated inflammatory microenvironment closely related severity appendectomy patients, an inflammatory‐microenvironment‐responsive nanomedicine designed by using poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles load chlorine E6 (Ce6), a photosensitizer, luminal (Lum), chemiluminescent agent. obtained Lum/Ce6@PLGA nanoparticles, being non‐toxic within normal physiological environment, can generate cytotoxic single oxygen via bioluminescence resonance energy transfer (BRET) with H MPO, simultaneously killing pathogens excessive lesion, without disturbing homeostasis. As evidenced various relevant bacterial infection models virus‐induced pneumonia, appeared be rather effective controlling both inflammation, resulting significantly improved animal survival. Therefore, BRET‐based infections inflammation promising nano‐therapeutics for treatment
Language: Английский
Citations
4
Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106691 - 106691
Published: Jan. 29, 2025
Language: Английский
Citations
0