Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Dysbiosis
of
the
gut
microbiota
is
emerging
as
a
pivotal
factor
in
pathogenesis
colorectal
cancer
(CRC).
Ginsenoside
Rh4
(Rh4)
an
active
compound
isolated
from
ginseng
with
beneficial
effects
modulating
intestinal
inflammation
and
dysbiosis,
but
how
regulates
to
alleviate
CRC
remains
underexplored.
We
investigated
impact
on
mechanism
its
action
inhibiting
via
modulation
microbiota.
used
AOM/DSS
model
employed
transcriptomics,
genomics
metabolomics
techniques
explore
inhibitory
CRC.
Furthermore,
we
experiments
involving
antibiotic
treatment
fecal
transplantation
(FMT)
investigate
role
Finally,
elucidated
key
functional
bacteria
metabolites
regulated
by
Our
research
findings
indicated
that
repaired
barrier
damage
caused
CRC,
alleviated
inflammation,
inhibited
development
Additionally,
microbiota-dependent
manner.
increased
diversity
microbiota,
enriched
probiotic
Akkermansia
muciniphila
(A.
muciniphila),
dysbiosis
Subsequently,
A.
muciniphila-mediated
bile
acid
metabolism.
promoted
production
UDCA
enhancing
activity
7α-hydroxysteroid
dehydrogenase
(7α-HSDH).
further
activated
FXR,
modulated
TLR4-NF-κB
signaling
pathway,
thus
results
confirm
inhibits
manner
microbiota-mediated
metabolism
promoting
UDCA,
which
activates
FXR
receptor
pathway.
has
potential
be
modulator
for
preventing
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Aug. 25, 2024
The
human
gastrointestinal
tract,
boasting
the
most
diverse
microbial
community,
harbors
approximately
100
trillion
microorganisms
comprising
viruses,
bacteria,
fungi,
and
archaea.
profound
genetic
metabolic
capabilities
of
gut
microbiome
underlie
its
involvement
in
nearly
every
facet
biology,
from
health
maintenance
development
to
aging
disease.
Recent
recognition
microbiota
–
brain
axis,
referring
bidirectional
communication
network
between
microbes
their
host,
has
led
a
surge
interdisciplinary
research.
This
review
begins
with
an
overview
current
understandings
regarding
influence
on
intestinal
blood-brain
barrier
integrity.
Subsequently,
we
discuss
mechanisms
examining
role
microbiota-related
neural
transmission,
metabolites,
hormones
immunity.
We
propose
concept
microbiota-mediated
multi-barrier
modulation
potential
treatment
neurological
disorders.
Furthermore,
lymphatic
function
is
discussed,
providing
insights
into
lesser-known
conduits
ecosystem
within
brain.
In
final
section,
conclude
by
describing
ongoing
frontiers
understanding
axis's
impact
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(8), P. 4142 - 4154
Published: Feb. 14, 2024
The
purpose
of
this
study
was
to
evaluate
the
preventive
role
and
underlying
mechanisms
fucoxanthin
(Fx)
on
dextran
sulfate
sodium
(DSS)-induced
colitis
in
mice.
present
data
demonstrated
that
oral
administration
Fx
(50
200
mg/kg
body
weight/day)
for
36
days
significantly
alleviated
severity
DSS-treated
mice,
as
evidenced
by
attenuating
weight
loss,
bloody
stool,
diarrhea,
shortened
colon
length,
colonic
epithelium
distortion,
a
thin
mucus
layer,
goblet
cell
depletion,
damaged
crypts,
extensive
infiltration
inflammatory
cells
mucosa.
Additionally,
notably
relieved
DSS-induced
intestinal
epithelial
barrier
dysfunction
via
maintaining
tight
junction
function
preventing
excessive
apoptosis
cells.
Moreover,
effectively
diminished
inflammation
oxidative
stress
its
might
be
due
blunting
activation
NF-κB
NLRP3
inflammasome
signaling
pathways.
Furthermore,
also
modulates
gut
microbiota
dysbiosis
recovering
richness
diversity
reshaping
structure
microbiota,
such
increasing
Journal of Agricultural and Food Chemistry,
Journal Year:
2024,
Volume and Issue:
72(21), P. 12119 - 12129
Published: May 18, 2024
Taurine
(Tau)
is
a
semiessential
amino
acid
in
mammals
with
preventive
and
therapeutic
effects
on
several
intestinal
disorders.
However,
the
exact
function
of
taurine
ulcerative
colitis
(UC)
still
largely
unclear.
In
this
study,
we
used
two
taurine-deficient
mouse
models
(CSAD–/–
TauT–/–
mice)
to
explore
influence
progression
UC
both
dextran
sulfate
sodium
(DSS)-induced
LPS-stimulated
Caco-2
cells.
We
found
that
cysteine
sulfinic
decarboxylase
(CSAD)
transporter
(TauT)
expressions
levels
were
markedly
reduced
colonic
tissues
mice
treated
DSS.
The
CSAD
TauT
knockouts
exacerbated
DSS-induced
clinical
symptoms
pathological
damage
aggravated
barrier
dysfunction
mucosal
inflammatory
response.
Conversely,
pretreatment
enhanced
functions
by
increasing
goblet
cells
upregulating
tight
junction
protein
expression.
Importantly,
bound
TLR4
inhibited
TLR4/NF-κB
pathway,
ultimately
reducing
proinflammatory
factors
(TNF-α
IL-6)
oxidative
stress.
Our
findings
highlight
essential
role
maintaining
integrity
inhibiting
inflammation,
indicating
promising
supplement
for
treatment.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Dysbiosis
of
the
gut
microbiota
is
emerging
as
a
pivotal
factor
in
pathogenesis
colorectal
cancer
(CRC).
Ginsenoside
Rh4
(Rh4)
an
active
compound
isolated
from
ginseng
with
beneficial
effects
modulating
intestinal
inflammation
and
dysbiosis,
but
how
regulates
to
alleviate
CRC
remains
underexplored.
We
investigated
impact
on
mechanism
its
action
inhibiting
via
modulation
microbiota.
used
AOM/DSS
model
employed
transcriptomics,
genomics
metabolomics
techniques
explore
inhibitory
CRC.
Furthermore,
we
experiments
involving
antibiotic
treatment
fecal
transplantation
(FMT)
investigate
role
Finally,
elucidated
key
functional
bacteria
metabolites
regulated
by
Our
research
findings
indicated
that
repaired
barrier
damage
caused
CRC,
alleviated
inflammation,
inhibited
development
Additionally,
microbiota-dependent
manner.
increased
diversity
microbiota,
enriched
probiotic
Akkermansia
muciniphila
(A.
muciniphila),
dysbiosis
Subsequently,
A.
muciniphila-mediated
bile
acid
metabolism.
promoted
production
UDCA
enhancing
activity
7α-hydroxysteroid
dehydrogenase
(7α-HSDH).
further
activated
FXR,
modulated
TLR4-NF-κB
signaling
pathway,
thus
results
confirm
inhibits
manner
microbiota-mediated
metabolism
promoting
UDCA,
which
activates
FXR
receptor
pathway.
has
potential
be
modulator
for
preventing
