Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments

Gastroenterology, Journal Year: 2024, Volume and Issue: 166(6), P. 976 - 994

Published: Feb. 5, 2024

Cofounder of pHarm Therapeutics Inc., a company that is developing pH sensitive analgesics selectively target sites inflammation where pain originates.PCK

Language: Английский

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Endocannabinoid System: Chemical Characteristics and Biological Activity

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(2), P. 148 - 148

Published: Jan. 19, 2023

The endocannabinoid system (eCB) has been studied to identify the molecular structures present in Cannabis sativa. eCB consists of cannabinoid receptors, endogenous ligands, and associated enzymatic apparatus responsible for maintaining energy homeostasis cognitive processes. Several physiological effects cannabinoids are exerted through interactions with various such as CB1 CB2 vanilloid recently discovered G-protein-coupled receptors (GPR55, GPR3, GPR6, GPR12, GPR19). Anandamide (AEA) 2-arachidoylglycerol (2-AG), two small lipids derived from arachidonic acid, showed high-affinity binding both receptors. plays a critical role chronic pain mood disorders extensively because its wide therapeutic potential it is promising target development new drugs. Phytocannabinoids synthetic have shown varied affinities relevant treatment several neurological diseases. This review provides description components discusses how phytocannabinoids other exogenous compounds may regulate balance. Furthermore, we show hypo- or hyperfunctionality body related disorders, even integrative complementary health practices (ICHP) harmonizing eCB.

Language: Английский

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Nutraceutical potential, phytochemistry of hemp seed (Cannabis sativa L.) and its application in food and feed: A review

Food Chemistry Advances, Journal Year: 2024, Volume and Issue: 4, P. 100671 - 100671

Published: March 23, 2024

Hemp seeds are gaining increasing attention in the realm of research due to their multifaceted nutritional and pharmaceutical properties. Notably, these offer a rich source protein, carbohydrates, polyunsaturated fatty acids, vitamins, minerals, making them valuable addition one's diet therefore, growing interest among researchers globally. A comprehensive literature review was conducted on prominent databases Scopus, Elsevier, PubMed using keywords "Hempseed," "Phytochemistry," "Nutraceuticals," food feed applications. Studies suggest that compounds exhibit therapeutic potential against conditions such as epilepsy, certain neurological disorders (Parkinson's Alzheimer's diseases), cardiovascular issues. Additionally, hemp possess other notable properties, anti-cancer, anti-inflammatory, immunomodulatory effects. They also used dietary supplement alleviate headaches, insomnia, high cholesterol levels, premenstrual syndrome symptoms women. Hempseed oil, powder, flour utilized enhance phenolic activity antioxidant properties products. hempseed cake, generated after cold pressing, boasts protein concentration, it for ruminants. However, further clinical trials necessary fully understand harness functional foods nutraceutical

Language: Английский

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Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 121 - 121

Published: Feb. 12, 2025

Background/Objectives: Irritable bowel syndrome (IBS) is a complex disorder affecting 10% of the global population, but underlying mechanisms remain poorly understood. By integrating multifluid metabolomics, we aimed to identify metabolite markers IBS in large population-based cohort. Methods: We included individuals from TwinsUK with and without IBS, ascertained using Rome III criteria, analysed serum (232 cases, 1707 controls), urine (185 1341 stool (186 1284 controls) metabolites (Metabolon Inc.). Results: After adjusting for covariates, multiple testing, 44 unique (25 novel) were associated including lipids, amino acids, xenobiotics. Androsterone sulphate, sulfated steroid hormone precursor, was lower odds both (0.69 [95% confidence interval = 0.56-0.85], p 2.34 × 10-4) (0.75 [0.63-0.90], 1.54 10-3. Moreover, suberate (C8-DC) higher (1.36 [1.15-1.61]; 1.84 (0.76 [0.63-0.91]; 2.30 10-3). On contrary, 32 appeared be fluid-specific, indole, 13-HODE + 9-HODE, pterin, bilirubin (E,Z or Z,Z), urolithin. The remaining 10 one fluid suggestive evidence (p < 0.05) another fluid. Finally, identified androgenic signalling, dicarboxylates, haemoglobin, porphyrin metabolism significantly over-represented compared controls. Conclusions: Our results highlight utility multi-fluid approach research, revealing distinct metabolic signatures across biofluids.

Language: Английский

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Multi-omics for biomarker approaches in the diagnostic evaluation and management of abdominal pain and irritable bowel syndrome: what lies ahead

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 3, 2023

Reliable biomarkers for common disorders of gut–brain interaction characterized by abdominal pain, including irritable bowel syndrome (IBS), are critically needed to enhance care and develop individualized therapies. The dynamic heterogeneous nature the pathophysiological mechanisms that underlie visceral hypersensitivity have challenged successful biomarker development. Consequently, effective therapies pain in IBS lacking. However, recent advances modern omics technologies offer new opportunities acquire deep biological insights into nociception. Newer methods large-scale data integration complementary approaches further expanded our ability build a holistic understanding complex networks their co-contributions pain. Here, we review hypersensitivity, focusing on IBS. We discuss candidate identified through single studies summarize emerging multi-omics developing novel may transform clinical patients with

Language: Английский

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Cannabinoids and the Gastrointestinal Tract

Clinical Gastroenterology and Hepatology, Journal Year: 2023, Volume and Issue: 21(13), P. 3217 - 3229

Published: Sept. 9, 2023

Language: Английский

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Irritable bowel syndrome in children: pathogenetic significance of disorders of intestinal microbiota

Russian Pediatric Journal, Journal Year: 2024, Volume and Issue: 27(1), P. 49 - 54

Published: Feb. 28, 2024

Irritable bowel syndrome (IBS) is the most common functional disorder of intestine in children. In recent years, IBS has been defined as pathology intestine, manifested by visceral recurrent pain that occurs at least once per week, characterized following two or more signs: associated with defecation; changes frequency and shape stools. These symptoms had to be noted patient for last 3 months, a total duration 6 without signs organic damage gastrointestinal tract (GIT). The gut microbiota particular importance pathogenesis IBS. patients IBS, an increase Enterobacteriaceae, Ruminococcus, Clostridium, Dorea species decrease number Lactobacillus, Bifidobacterium Faecalibacterium were found. At same time, similar microbial profile was found different subtypes established patterns composition children adults indicate disorders GIT have pronounced pathogenesis. this regard, personalized use prebiotics, probiotics, synbiotics, fecal transplantation can effectively affect intestinal microbiome Conclusion. Correction important method treating Determining formation creates new opportunities improving methods their correction.

Language: Английский

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Update on treatment of abdominal pain in irritable bowel syndrome: A narrative review

Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 245, P. 108400 - 108400

Published: March 30, 2023

Language: Английский

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Microwave‐assisted synthesis of 4,4‐dimethylsterol‐conjugated linoleic acid ester and its lipid‐lowering benefits evaluation

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)

Published: April 1, 2025

Abstract 4,4‐Dimethylsterol (RST), rich in rice bran oil, is often considered to have good lipid‐lowering properties, and conjugated linoleic acid (CLA), a special fatty acid, also similar but the low solubility poor oxidation stability limits their application food industry. Typically, sterol esters better after esterification. However, it difficult esterify 4,4‐dimethylsterol for its additional methyl groups. Therefore, microwave‐assisted esterification of with CLA was developed this study, function 4,4‐dimethylsterol–CLA (RSE) evaluated high‐fat diet (HFD)‐induced mice model. The results showed that when reaction condition molar ratio RST 1:3 catalyzed 5% (mol%) p‐toluene sulfonic 25% dodecyl benzene maintained at microwave reactor 125 min 100°C, highest rate 93.63% acquired. Furthermore, HFD‐induced experiments demonstrated RSE could significantly reduce body weight, as well serum liver triglyceride (TG) levels, while exert hepatoprotective properties compared RST. Additionally, found affect appetite regulate expression lipid metabolism–related genes mice. These findings suggest holds potential field functional foods.

Language: Английский

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Isolation of cannabinoids and triterpenoids from Rhododendron anthopogon D.Don (Ericaceae) Leaves

Natural Product Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 4

Published: May 20, 2025

Rhododendron anthopogon D.Don (Ericaceae) is a medicinal plant that occurs in the Swat District, Pakistan. Column chromatography was used to isolate cannabichromeorcinic acid (1), cannabigerorcinic (2), ursolic (3), friedelin (4) and 2-phenylethyl 4-methoxybenzoate (5) from methylene chloride extract of R. leaves were collected Daral region The structures isolated compounds elucidated using nuclear magnetic resonance spectroscopy mass spectrometry, by comparison experimental data with those reported literature. occurrence cannabinoids (1) triterpenoids (3) (4), leaves, as this study, may shed some light on species' traditional uses.

Language: Английский

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