Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years DOI Creative Commons
József Haller

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(6), P. 689 - 689

Published: May 27, 2024

Public perception contrasts scientific findings on the depression-related effects of cannabis. However, earlier studies were performed when cannabis was predominantly illegal, its production mostly uncontrolled, and idea medical incipient only. We hypothesized that recent changes in attitudes legislations may have favorably affected research. In addition, publication bias against also decreased. To investigate this hypothesis, we conducted a review research published over last three years. found 156 relevant articles. most cross-sectional studies, depression higher those who consumed than did not. An increase consumption typically followed by an depression, whereas withdrawal from ameliorated cases. Although reduced none these placebo-controlled. clinical same period, placebo and, average effect size larger investigated plausibility antidepressant reviewing molecular pharmacological studies. Taken together, reviewed do not support herbal

Language: Английский

The changing metabolic landscape of bile acids – keys to metabolism and immune regulation DOI
Ipsita Mohanty, Celeste Allaband, Helena Mannochio-Russo

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(7), P. 493 - 516

Published: April 4, 2024

Language: Английский

Citations

59
Cannabis sativa: origin and history, glandular trichome development, and cannabinoid biosynthesis DOI Creative Commons
Ziyan Xie,

Yaolei Mi,

Lingzhe Kong

et al.

Horticulture Research, Journal Year: 2023, Volume and Issue: 10(9)

Published: July 26, 2023

Is Cannabis a boon or bane? sativa has long been versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). faced global prohibition in the twentieth century because of psychoactive properties ∆9-tetrahydrocannabinol; however, recently, perspective changed with recognition additional therapeutic values, particularly pharmacological potential cannabidiol. A comprehensive understanding underlying mechanism cannabinoid biosynthesis is necessary to cultivate promote globally medicinal application resources. Here, we comprehensively review historical usage Cannabis, trichome-specific cannabinoids, regulatory network trichome development, synthetic biology cannabinoids. This provides valuable insights into efficient green production development utilization novel varieties.

Language: Английский

Citations

23
CBD in the Treatment of Epilepsy DOI Creative Commons
Kinga K. Borowicz-Reutt, Julia Czernia, Marlena Krawczyk

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(9), P. 1981 - 1981

Published: April 25, 2024

It has been several years since highly purified cannabidiol (CBD) was registered as a medication that can be used in children of at least 2 age to treat different types seizures related Lennox–Gastaut syndrome (LGS), Dravet (DS), and more recently tuberous sclerosis complex (TSC). During this time, 39 randomized clinical trials (RCTs) 13 meta-analyses on the efficacy safety CBD treatment have published. Each had its own criteria for RCTs’ inclusion and, therefore, slightly interpretations analyzed data. them contributed way understanding pharmacology, mechanisms therapeutic action, development adverse reactions, drug–drug interactions. Hence, it seemed reasonable gather most relevant data one article present all current knowledge use epilepsy. The results presented herein confirmed effectiveness adolescents with DREs. In adults, reliable conclusions cannot drawn due insufficient

Language: Английский

Citations

6
The endocannabinoid system as a therapeutic target in neuropathic pain: a review DOI
Jose-Manuel Quintero, Luis E. Díaz, Ismael Galve‐Roperh

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: 28(9), P. 739 - 755

Published: Sept. 1, 2024

This review highlights the critical role of endocannabinoid system (ECS) in regulating neuropathic pain and explores therapeutic potential cannabinoids. Understanding mechanisms ECS, including its receptors, endogenous ligands, enzymatic routes, can lead to innovative treatments for chronic pain, offering more effective therapies conditions. bridges gap between preclinical studies clinical applications by emphasizing ECS modulation better management outcomes.

Language: Английский

Citations

6
Neurolipid systems: A new target for the treatment of dementia DOI Creative Commons
Gorka Pereira‐Castelo, Iker Bengoetxea de Tena, Jonatan Martínez‐Gardeazabal

et al.

Basic & Clinical Pharmacology & Toxicology, Journal Year: 2024, Volume and Issue: 135(3), P. 225 - 236

Published: July 22, 2024

Abstract Neurolipids comprise a diverse class of bioactive lipids that include molecules capable activating G protein‐coupled receptors, thereby inducing systemic effects contribute to the maintenance homeostasis. Dementia, non‐specific brain disorder characterized by common set signs and symptoms, usually arises subsequent injuries or diseases is often associated with aging process. Individuals affected dementia suffer from disruption several neurotransmitter neuromodulatory systems, among which neurolipids play an important role, including endocannabinoid, lysophosphatidic acid sphingosine 1‐phosphate systems. In this review, we present overview most recent pertinent findings regarding involvement these neurolipidic systems in dementia, data wide range both vitro vivo experiments as well clinical trials.

Language: Английский

Citations

4
The Endocannabinoid System: The Most Important System You Never Learned in School DOI
Leah Sera,

Carrie Hempel-Sanderoff

Published: Jan. 1, 2025

Language: Английский

Citations

0
Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response DOI Creative Commons
Erynn E. Johnson, James M. Ervasti

FEBS Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Duchenne muscular dystrophy is a severe neuromuscular wasting disease that caused by primary defect in dystrophin protein and involves organism‐wide comorbidities such as cardiomyopathy, metabolic mitochondrial dysfunction, nonprogressive cognitive impairments. Physiological stress exposure the mdx mouse model of results phenotypic abnormalities include locomotor inactivity, hypotension, increased morbidity. Severe lethal susceptibility mice corresponds to dysfunction several coordinated pathways within dystrophin‐deficient skeletal muscle, well prolonged elevation plasma corticosterone levels extends beyond wild‐type (WT) response. Here, we performed targeted mass spectrometry‐based metabolomics screen focused on biological healthy exposed mild scruff stress. One‐third stress‐relevant metabolites interrogated displayed significant or depletion after were restored WT muscle‐specific expression. The altered are associated with regulation hypothalamic–pituitary–adrenal axis, tone, neurocognitive function, redox metabolism, cellular bioenergetics, catabolism. Our data suggest triggers an exaggerated, multi‐system response mice.

Language: Английский

Citations

0
Impact of Cannabis Use on Deep Inferior Epigastric Perforator Autologous Breast Reconstruction: analysis of 719 patients and 1148 flaps DOI
John Park, Maria J. Escobar‐Domingo,

Micaela Tobin

et al.

Annals of Plastic Surgery, Journal Year: 2025, Volume and Issue: 94(4S), P. S188 - S193

Published: April 1, 2025

Introduction Given recent efforts to legalize and decriminalize recreational marijuana, its use has become increasingly common in the plastic surgery patient population. Although cannabis generally been considered lower risk than of other substances, studies have suggested it may be associated with an increased surgical complication rate. The aims our study were (1) characterize extent (2) determine clinical effects cohort patients undergoing autologous breast reconstruction using deep inferior epigastric perforator (DIEP) flaps. Methods A retrospective was conducted adult who underwent DIEP flaps between January 2015 December 2023 by 5 surgeons at institution. Patients divided into 2 groups users nonusers. Univariate multivariable analyses performed assess outcomes groups. Results total 87 (12.1%) 632 nonusers included. 5-fold increase proportion from found. Cannabis significantly younger (47.5 vs 51.7, P < 0.001) had a higher body mass index (30.5 28.9, = 0.012). Postoperatively, readmission rate (8.0% 3.2%, 0.035) longer time last abdominal drain removal (21 17 days, 0.001). After controlling for confounders, logistic regression revealed as significant factor postoperative general hematoma (OR: 3.078, confidence interval [95% CI]: 1.265–7.491, 0.013), 3.098, 95% CI: 1.197–8.020, 0.020), 2.865, 1.098–7.475, 0.031). Conclusion To knowledge, this is largest examining receiving reconstruction. Our findings suggest that require greater care attention.

Language: Английский

Citations

0
Anxiety Modulation by Cannabinoids—The Role of Stress Responses and Coping DOI Open Access
József Haller

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15777 - 15777

Published: Oct. 30, 2023

Endocannabinoids were implicated in a variety of pathological conditions including anxiety and are considered promising new targets for anxiolytic drug development. The optimism concerning the potentials this system anxiolysis is probably justified. However, complexity mechanisms affected by endocannabinoids, discrepant findings obtained with various experimental approaches makes interpretation research results difficult. Here, we review anxiety-related effects three main interventions used to study endocannabinoid system: pharmacological agents active at endocannabinoid-binding sites present on both cell membrane cytoplasm, genetic manipulations targeting cannabinoid receptors, function-enhancers represented inhibitors degradation transport. Binding-site ligands provide inconsistent because they activate multitude concomitantly. More robust particularly function enhancers, which heighten ongoing activation rather than affecting all indiscriminately. enhancement activity appears ameliorate stress-induced without consistent general. Limited evidence suggests that effect achieved promoting coping styles critical situations. These suggest functional signaling development target stress-related disorders.

Language: Английский

Citations

10
The Interaction of the Endocannabinoid Anandamide and Paracannabinoid Lysophosphatidylinositol during Cell Death Induction in Human Breast Cancer Cells DOI Open Access
Mikhail Akimov, N. M. Gretskaya, Evgenia I. Gorbacheva

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2271 - 2271

Published: Feb. 14, 2024

Endocannabinoid anandamide (AEA) and paracannabinoid lysophosphatidylinositol (LPI) play a significant role in cancer cell proliferation regulation. While inhibits the of cells, LPI is known as stimulant. Despite endocannabinoid receptor crosstalk simultaneous presence microenvironment both molecules, their combined activity has never been studied. We evaluated effect on AEA six human breast lines different carcinogenicity (MCF-10A, MCF-7, BT-474, BT-20, SK-BR-3, MDA-MB-231) using resazurin LDH tests after 72 h incubation. exerted anti-proliferative cytotoxic with EC50 range from 31 to 80 µM. did not significantly affect viability. Depending line, response LPI–AEA combination varied decrease cytotoxicity an increase it. Based inhibitor analysis panel, we showed that for former effect, active GPR18 was required latter, CB2 receptor. The data obtained first time are important understanding manner by which ligands acting simultaneously can modulate growth at stages.

Language: Английский

Citations

3