Serum metabolomics to identify molecular subtypes and predict XELOX efficacy in colorectal cancer DOI Creative Commons
Yijie Zhang, Lizhen Ye,

Ying Qin

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 21, 2025

Colorectal cancer (CRC) is one of the most common cancers; however, accurately predicting prognosis based on existing molecular subtypes remains challenging. The XELOX regimen, which combines oxaliplatin and capecitabine, cornerstone chemotherapy for CRC treatment. However, there a notable lack reliable predictive models determining sensitivity this This study aimed to establish novel classification system develop model chemotherapeutic using serum metabolomics. We recruited 89 patients with age- sex-matched healthy controls untargeted metabolomic studies identify tumor-specific metabolites. were grouped into distinct metabolic unsupervised clustering. A metabolite combination efficacy was established Cox regression analysis in 34 stage III CRC. Using clustering metabolites, three clusters identified. Notably, Cluster 3, characterized by uniform lipid amino acid levels, demonstrated best prognosis. Our revealed that D-glucose 6-phosphate, presqualene diphosphate, leukotriene B4 levels negatively correlated sensitivity, whereas 15-HETE N-acetyl-l-methionine positively correlated. Based these findings, we constructed validated an independent cohort In summary, identified metabolites developed potential prognostic efficacy, may have direct effects treatment

Language: Английский

Differences in cancer rates among adults born between 1920 and 1990 in the USA: an analysis of population-based cancer registry data DOI Creative Commons
Hyuna Sung,

Chenxi Jiang,

Priti Bandi

et al.

The Lancet Public Health, Journal Year: 2024, Volume and Issue: 9(8), P. e583 - e593

Published: July 31, 2024

BackgroundTrends in cancer incidence recent birth cohorts largely reflect changes exposures during early life and foreshadow the future disease burden. Herein, we examined mortality trends, by cohort, for 34 types of USA.MethodsIn this analysis, obtained data 25 individuals aged 25–84 years period Jan 1, 2000, to Dec 31, 2019 from North American Association Central Cancer Registries US National Center Health Statistics, respectively. We calculated cohort-specific rate ratios (IRRs) (MRRs), adjusted age effects, nominal separated 5 year intervals, 1920 1990.FindingsWe extracted 23 654 000 patients diagnosed with 7 348 137 deaths cancers 2019. found that IRRs increased each successive cohort born since approximately eight (pcohort<0·050). Notably, was two-to-three times higher 1990 than 1955 small intestine (IRR 3·56 [95% CI 2·96–4·27]), kidney renal pelvis (2·92 [2·50–3·42]), pancreatic (2·61 [2·22–3·07]) both male female individuals; liver intrahepatic bile duct (2·05 [1·23–3·44]). Additionally, younger cohorts, after a decline older nine remaining (pcohort<0·050): oestrogen-receptor-positive breast cancer, uterine corpus colorectal non-cardia gastric gallbladder other biliary ovarian testicular anal individuals, Kaposi sarcoma individuals. Across types, ranged 12% (IRR1990 vs 1975 1·12 1·03–1·21] cancer) 169% 1930 2·69 [2·34–3·08] lowest rate. The MRRs successively alongside corpus, biliary, testicular, cancers, while declined or stabilised most types.Interpretation17 had an increasing including previously declining cohorts. These findings add growing evidence risk generations, highlighting need identify tackle underlying factors.FundingAmerican Society.

Language: Английский

Citations

16
Rising Burden of Colon and Rectum Cancer in China: An Analysis of Trends, Gender Disparities, and Projections to 2030 DOI
Zhouwei Zhan, Bijuan Chen, Wei Lin

et al.

Annals of Surgical Oncology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Language: Английский

Citations

3
Mast cells: key players in digestive system tumors and their interactions with immune cells DOI Creative Commons

Feihong Shu,

Jie Yu,

Youjia Liu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 15, 2025

Abstract Mast cells (MCs) are critical components of both innate and adaptive immune processes. They play a significant role in protecting human health the pathophysiology various illnesses, including allergies, cardiovascular diseases autoimmune diseases. Recent studies tumor-related research have demonstrated that mast exert substantial influence on tumor cell behavior microenvironment, exhibiting pro- anti-tumor effects. Specifically, not only secrete mediators related to pro-tumor function such as trypsin-like enzymes, chymotrypsin, vascular endothelial growth factor histamine, but also progression cystatin C IL-17F. This dual renders them an under-recognized very promising target for immunotherapy. Digestive system tumors, characterized by high morbidity associated mortality rates globally, increasingly recognized healthcare burden. paper examines cell-derived development tumors digestive system. It explores prognostic significance patients with gastrointestinal cancers at different stages disease. Additionally, article investigates interactions between cells, well potential relationships among intratumoral bacteria, within microenvironment. The aim is propose new strategies immunotherapy targeting cells.

Language: Английский

Citations

1
Developing a novel model for predicting overall survival in late-onset colon adenocarcinoma patients based on LODDS: a study based on the SEER database and external validation DOI Creative Commons
Chen Chen,

Heng-Bo Xia,

Weiwei Yuan

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 29, 2025

Language: Английский

Citations

1
miR-485-5p/NQO1 axis drives colorectal cancer progression by regulating apoptosis and aerobic glycolysis DOI Creative Commons
Yixuan Wang,

Houkun Zhou,

Ying Liu

et al.

Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 12, 2025

Language: Английский

Citations

1
Distinct Immunophenotypic Profiles and Neutrophil Heterogeneity in Colorectal Cancer DOI

Minghua Bai,

Yuzhao Jin,

Zihao Jin

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: 616, P. 217570 - 217570

Published: Feb. 22, 2025

Language: Английский

Citations

1
Global, Regional, and National Disease Burden and Prediction Analysis of Colorectal Cancer Attributable to Tobacco, Alcohol, and Obesity From 1990 to 2030 DOI Creative Commons

Yuqi Deng,

Yajie Wang,

Jinsai Yang

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 26, 2025

Colorectal cancer (CRC) ranks among the highest in incidence and mortality rates globally. A significant portion of cases deaths can be attributed to modifiable risk factors, with smoking, alcohol use, high body mass index (BMI) being three most prominent. However, impact these factors on across regions, genders, age groups remains insufficiently characterized. Utilizing data from Global Burden Disease (GBD) study 2019, restrictive cubic splines (RCS) quantile regression analyses are applied explore relationship between Socio-Demographic Index (SDI) ASMR or ASDR. Additionally, gender differences, changes different SDI levels, group trends BMI over 30-year period analyzed. The Bayesian age-period-cohort (BAPC) model is employed predict 2020 2030, aiming epidemiological sociodemographic transitions disease burden BMI. In number colorectal globally attributable as consumption, obesity increased 142,931, 52,495, 85,882 respectively, collectively accounting for approximately one-third all cancer-related deaths. Notably, there an upward trend early-onset associated factors. To reduce cancer, it recommended enhance health education, promote smoking cessation moderation, increase coverage participation screening, which crucial lowering rates. These findings vital development public policies intervention measures global burden. They provide guidance prevention worldwide.

Language: Английский

Citations

1
Intercellular crosstalk between cancer cells and cancer-associated fibroblasts via exosomes in gastrointestinal tumors DOI Creative Commons

Longyang Cao,

Hong Ouyang

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 23, 2024

Gastrointestinal (GI) tumors are a significant global health threat, with high rates of morbidity and mortality. Exosomes contain various biologically active molecules like nucleic acids, proteins, lipids can serve as messengers for intercellular communication. They play critical roles in the exchange information between tumor cells microenvironment (TME). The TME consists mesenchymal components extracellular matrix (ECM), fibroblasts being most abundant cell type mesenchyme. Cancer-associated (CAFs) derived from normal stem that activated TME. CAFs secrete exosomes to modulate proliferation, invasion, migration, drug resistance, other biological processes tumors. Additionally, manipulate function behavior through direct cell-cell interactions. This review provides summary crosstalk GI exosomes, along potential underlying mechanisms.

Language: Английский

Citations

8
Role of Hippo pathway dysregulation from gastrointestinal premalignant lesions to cancer DOI Creative Commons
Giulia Schiavoni, Beatrice Messina, Stefano Scalera

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 29, 2024

Abstract Background First identified in Drosophila melanogaster , the Hippo pathway is considered a major regulatory cascade controlling tissue homeostasis and organ development. signaling components include kinases whose activity regulates YAP TAZ final effectors. In response to upstream stimuli, control transcriptional programs involved cell proliferation, cytoskeletal reorganization stemness. Main text While fine tuning of essential for maintaining balance between proliferative non-proliferative signals, frequently dysregulated gastrointestinal cancers. Also, YAP/TAZ aberrant activation has been described conditions characterized by chronic inflammation that precede cancer development, suggesting role effectors triggering carcinogenesis. this review, we summarize architecture discuss involvement unbalances premalignant lesions tract, providing focus on underlying molecular mechanisms. Conclusions The biology dysregulation needs further investigation order elucidate evolutionary trajectories inititation develop effective early therapeutic strategies targeting Hippo/YAP pathway.

Language: Английский

Citations

7
The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990–2019: a secondary analysis for the global burden of disease study 2019 DOI Creative Commons

Jiao Su,

Yuanhao Liang, Xiao‐Feng He

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: May 31, 2024

Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of CRC attributable to dietary risks remain unclear.

Language: Английский

Citations

7