Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

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Structure, unique biological properties, and mechanisms of action of transforming growth factor β

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 150, P. 107611 - 107611

Published: July 1, 2024

Language: Английский

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Decellularized tissues as platforms for digestive system cancer models

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31589 - e31589

Published: May 21, 2024

The extracellular matrix (ECM) is a multifunctional network of macromolecules that regulate various cellular functions and physically support the tissues. Besides physiological conditions, ECM also changes during pathological conditions such as cancer. As tumor cells proliferate, notable occur in quantity makeup surrounding ECM. Therefore, role this noncellular component tissues studies microenvironments should be considered. So far, many attempts have been made to create 2-dimensional (2D) or 3-dimensional (3D) models can replicate intricate connections within microenvironment. Decellularized are proper scaffolds imitate complex nature native This review aims summarize 3D digestive system cancers based on decellularized ECMs. These ECM-based will enable us study interactive communication between their environment which brings new potential for better understanding pathophysiology

Language: Английский

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Heterocellular Adhesion in Cancer Invasion and Metastasis: Interactions between Cancer Cells and Cancer-Associated Fibroblasts

Cancers, Journal Year: 2024, Volume and Issue: 16(9), P. 1636 - 1636

Published: April 24, 2024

Cancer invasion is a requisite for the most malignant progression of cancer, that is, metastasis. The mechanisms cancer were originally studied using in vitro cell culture systems, which cells cultured artificial extracellular matrices (ECMs). However, conventional systems do not precisely recapitulate vivo because phenotypes tumor tissues are strongly affected by microenvironment (TME). Cancer-associated fibroblasts (CAFs) abundant type TME and accelerate through invasion, metastasis, therapy resistance, immune suppression. Thus, reciprocal interactions between CAFs have been extensively studied, leading to identification factors mediate cellular interactions, such as growth factors, cytokines, vesicles. In addition, importance direct heterocellular adhesion has recently elucidated. particular, directly associated with cells, allowing them invade ECM metastasize distant organs. this review, we summarize recent progress understanding molecular interaction CAF-led an emphasis on gastric cancer.

Language: Английский

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PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer

Translational Oncology, Journal Year: 2024, Volume and Issue: 48, P. 102080 - 102080

Published: Aug. 7, 2024

Gastric cancer (GC) is the fourth leading cause of deaths, with advanced cases having a median survival less than one year. Neoadjuvant chemotherapy (NCT) vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing are poorly understood.

Language: Английский

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GPD1L may inhibit the development of esophageal squamous cell carcinoma through the PI3K/AKT signaling pathway： bioinformatics analysis and experimental exploration

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

Background Esophageal squamous carcinoma (ESCC) is the most prevalent pathological subtype of esophageal cancer (EC). It has characteristics significant local invasion, quick disease progression, high recurrence rates, and a dismal prognosis for survival. Phosphatidylinositol 3-kinase/serine-threonine kinase (PI3K/AKT) signaling system whose aberrant activation regulates downstream factors, leading to promotion development. This study looks at protein called Glycerol-3-phosphate dehydrogenase 1-like (GPD1L), which strongly affects development several cancers. However, its association with ESCC underlying mechanisms are not clear. Methods In this paper, we analyzed six transcriptome data obtained from GEO database. We utilized bioinformatics technology immunohistochemistry differentially analyze GPD1L levels mRNA expression in normal adjacent tissues. Furthermore, conducted survival, co-expression, enrichment, immune infiltration drug sensitivity analysis. Finally, further investigated role mechanism by Western Blot (WB), Cell Counting Kit-8 (CCK8), wound healing assay, Transwell flow cytometry. Results The findings manifest that was low ESCC, functional experiments showed promoted apoptosis vitro while blocking cell migration, proliferation. Based on research, GPD1L's impact could be explained suppression PI3K/AKT pathway's activation. Conclusion To sum up, our imply may impede initiation advancement via modulating pathway. considered promising therapeutic target biomarker diagnose treat ESCC.

Language: Английский

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The role of miRNAs in the extracellular vesicle-mediated interplay between breast tumor cells and cancer-associated fibroblasts

Journal of Cancer Metastasis and Treatment, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

The tumor microenvironment (TME) of breast cancer (BC) is depicted as an immunosuppressive dwelling that comprises a myriad cell types embedded in the extracellular matrix. As one most abundant populations within TME, cancer-associated fibroblasts (CAFs) play indispensable roles increasing aggressiveness and promoting resistance to standard-of-care therapies. Extracellular vesicles (EVs) represent diverse array biological nanoparticles, encompassing exosomes, microvesicles, apoptotic bodies. In recent years, these cell-derived membranous structures have raised great interest they can encapsulate numerous cellular cargo, such proteins, lipids, miRNAs. By transmitting bioactive content recipient cells, EVs pivotal intercellular communication between CAFs cells. secreted from cells typically activate resident acquire myofibroblastic phenotype, while diffused by CAFs, turn, substantially increase progression BC. This review summarizes latest findings highlight functional role EV especially miRNAs, regulatory network. A better understanding EV-mediated cell-cell interactions crucial achieving effective treatment patients with

Language: Английский

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GPD1L may inhibit the development of esophageal squamous cell carcinoma through the PI3K/AKT signaling pathway: bioinformatics analysis and experimental exploration

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Nov. 13, 2024

Language: Английский

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