Therapeutic Potential of Cranberry Proanthocyanidins in Addressing the Pathophysiology of Metabolic Syndrome: A Scrutiny of Select Mechanisms of Action DOI Creative Commons
Francis Feldman,

Mireille Koudoufio,

Alain Théophile Sané

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 268 - 268

Published: Feb. 26, 2025

Metabolic syndrome (MetS) constitutes a spectrum of interconnected conditions comprising obesity, dyslipidemia, hypertension, and insulin resistance (IR). While singular, all-encompassing treatment for MetS remains elusive, an integrative approach involving tailored lifestyle modifications emerging functional food therapies holds promise in preventing its multifaceted manifestations. Our main objective was to scrutinize the efficacy cranberry proanthocyanidins (PAC, 200 mg/kg/day 12 weeks) mitigating pathophysiology male mice subjected standard Chow or high-fat/high-fructose (HFHF) diets while unravelling intricate mechanisms. The administration PAC, conjunction with HFHF diet, significantly averted evidenced by reductions body weight, adiposity across various fat depots, adipocyte hypertrophy. Similarly, PAC prevented HFHF-induced hyperglycemia hyperinsulinemia also lessening IR. Furthermore, proved effective alleviating key risk factors associated cardiovascular diseases diminishing plasma saturated fatty acids, as well levels triglycerides, cholesterol, non-HDL-C levels. rise adiponectin drop circulating inflammatory markers showcased PAC's protective role against inflammation. To better clarify mechanisms behind actions, gut-liver axis parameters were examined, showing significant enhancements gut microbiota composition, microbiota-derived metabolites, marked intestinal hepatic inflammation, liver steatosis, biomarkers endoplasmic reticulum (ER) stress lipid metabolism. This study enhances our understanding complex underlying development provides valuable insights into how may alleviate cardiometabolic dysfunction mice.

Language: Английский

The underappreciated diversity of bile acid modifications DOI Creative Commons
Ipsita Mohanty, Helena Mannochio-Russo,

Joshua V. Schweer

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(7), P. 1801 - 1818.e20

Published: March 1, 2024

The repertoire of modifications to bile acids and related steroidal lipids by host microbial metabolism remains incompletely characterized. To address this knowledge gap, we created a reusable resource tandem mass spectrometry (MS/MS) spectra filtering 1.2 billion publicly available MS/MS for bile-acid-selective ion patterns. Thousands are distributed throughout animal human bodies as well cultures. We employed library identify polyamine amidates, prevalent in carnivores. They present humans, their levels alter with diet change from Mediterranean typical American diet. This work highlights the existence many more acid than previously recognized value leveraging public large-scale untargeted metabolomics data discover metabolites. availability modification-centric will inform future studies investigating roles health disease.

Language: Английский

Citations

70
What defines a healthy gut microbiome? DOI
Matthias Van Hul, Patrice D. Cani, Camille Petitfils

et al.

Gut, Journal Year: 2024, Volume and Issue: 73(11), P. 1893 - 1908

Published: Sept. 25, 2024

The understanding that changes in microbiome composition can influence chronic human diseases and the efficiency of therapies has driven efforts to develop microbiota-centred such as first next generation probiotics, prebiotics postbiotics, microbiota editing faecal transplantation. Central research is how disease impacts vice versa, yet there a problematic issue with term 'dysbiosis', which broadly links microbial imbalances various illnesses without precision or definition. Another significant discussions defining 'healthy individuals' ascertain what characterises healthy microbiome. This involves questioning who represents healthiest segment our population-whether it those free from illnesses, athletes at peak performance, individuals living healthily through regular exercise good nutrition even elderly adults centenarians have been tested by time achieved remarkable longevity.This review advocates for delineating 'what defines microbiome?' considering broader range factors related health environmental influences on microbiota. A undoubtedly linked gut health. Nevertheless, very difficult pinpoint universally accepted definition 'gut health' due complexities measuring functionality besides composition. We must take into account individual variabilities, diet, lifestyle, host factors. Moreover, challenge distinguishing causation correlation between overall presented.The also highlights resource-heavy nature comprehensive assessments, hinders their practicality broad application. Finally, we call continued nuanced approach better understand intricate evolving concept health, emphasising need more precise inclusive definitions methodologies studying

Language: Английский

Citations

48
Immunology of bile acids regulated receptors DOI
Stefano Fiorucci, Silvia Marchianò,

Ginevra Urbani

et al.

Progress in Lipid Research, Journal Year: 2024, Volume and Issue: 95, P. 101291 - 101291

Published: July 1, 2024

Language: Английский

Citations

13
Gut microbial metabolites in lung cancer development and immunotherapy: Novel insights into gut-lung axis DOI
Xinpei Li,

Shijie Shang,

Meng Wu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217096 - 217096

Published: July 4, 2024

Language: Английский

Citations

11
Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions DOI Creative Commons

Haohao Zhang,

Yadong Xie, Fei Cao

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: July 24, 2024

Commensal microorganisms in the human gut produce numerous metabolites by using small molecules derived from host or diet as precursors. Host dietary lipid are involved energy metabolism and maintaining structural integrity of cell membranes. Notably, microbes can convert these lipids into bioactive signaling through their biotransformation synthesis pathways. These microbiota-derived affect physiology influencing body's immune metabolic processes. This review aims to summarize recent advances microbial transformation immunomodulatory functions metabolites, with a special focus on fatty acids steroids produced our microbiota.

Language: Английский

Citations

10
Bile acid metabolism in type 2 diabetes mellitus DOI
Marti Cadena Sandoval, Rebecca A. Haeusler

Nature Reviews Endocrinology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

Citations

1
Exploring new Bacteroidota strains: Functional Diversity and Probiotic Characteristics DOI Creative Commons

Lisa Ladewig,

Muhammad Aammar Tufail, Birhanu M. Kinfu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Abstract Bacteroidota, a diverse phylum of bacteria, are increasingly recognized for their significant contributions to host health, particularly through antimicrobial and probiotic properties. This study investigates the functional diversity potential 42 new Bacteroidota strains enriched identified from hosts, including mouse ceca human stool samples. Using 16S rRNA gene sequencing, we phylogenetically characterized genera Bacteroides, Phocaeicola Sphingobacterium assessed properties related potential. The were evaluated concerning ability inhibit biofilm formation WHO declared clinically pathogens, gram-positive Staphylococcus aureus epidermidis , gram-negative Klebsiella oxytoca Pseudomonas aeruginosa eukaryotic fungus Candida albicans. Additionally, investigated bile salt hydrolase quorum quenching activities strains, key traits associated with efficacy. Our findings demonstrate that all examined consistently exhibit capacity but different extent. Furthermore, 14 showed activity, 39 highlighting High inhibition as well activity against both autoinducers, AHL AI-2, predominantly observed in Bacteroides caecimuris muris making them attractive candidates next-generation probiotics. Overall, this advances field probiotics by identifying promising therapeutic applications potentially revolutionizing approaches microbiome-based interventions pathogen control clinical settings.

Language: Английский

Citations

1
Genome Mining and Characterization of Two Novel Lacticaseibacillus rhamnosus Probiotic Candidates with Bile Salt Hydrolase Activity DOI Creative Commons
Gianluigi Agolino,

Marianna Cristofolini,

Amanda Vaccalluzzo

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 86 - 86

Published: Jan. 8, 2025

Bile salt hydrolase (BSH; EC 3.5.1.24) is the microbial enzyme that catalyzes conversion of primary bile acids (BAs) into secondary ones, promoting adaptation and modulating several host's biological functions. Probiotics with BSH activity are supposed to survive harsh intestinal conditions exert a cholesterol-lowering effect. Here, Lacticaseibacillus rhamnosus strains (VB4 VB1), isolated from vaginal ecosystem, were submitted genomic survey, in vitro activity, BAs tolerance assay unravel their probiotic potential as modulators. The draft genomes Lcb. VB4 VB1 comprised 2769 2704 CDSs, respectively. Gene annotation revealed numerous strain-specific genes involved metabolism transport, well DNA recombination. Each strain harbors single bsh gene, encoding C-N amide hydrolase, which conserved essential residues required core site. According results, compared VB1, tolerated better stress was more active deconjugating BAs. However, increased gene transcription but not strain, suggesting partially nonlinear relationship between expression. In conclusion, despite complexity transcriptional system, results support promising BAs-deconjugating candidate.

Language: Английский

Citations

1
Morin attenuates high-fat diet induced inflammation and enhances the Akkermansiaceae richness in the gut of C57BL/6J mice DOI

V. Prashanth,

Arun Kumar Devarajan, Madan Kumar Perumal

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106153 - 106153

Published: Feb. 1, 2025

Language: Английский

Citations

1
Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut–Brain Axis and Therapeutic Potential of Microbiota Modulation DOI Open Access
Victòria Ayala,

Laia Fontdevila,

Santiago Rico-Rios

et al.

Sclerosis, Journal Year: 2025, Volume and Issue: 3(1), P. 8 - 8

Published: March 5, 2025

Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The gut microbiota, community microorganisms in digestive tract, has recently been implicated ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. This review explores potential role microbiota metabolites progression investigates therapeutic approaches targeting microbiota. Methods: A comprehensive current literature was conducted to assess relationship between composition, microbial metabolites, patients. We searched for published reports ALS, emphasizing complex interplay dysbiosis, neuroinflammation, systemic metabolism. Special emphasis placed studies exploring short-chain fatty acids (SCFAs), bacterial amyloids (curli-like factors), neurotoxins such as β-methylamino-L-alanine (BMAA). liver–gut axis evaluated well. changes would sustain rationale strategies probiotics, prebiotics, fecal transplantation (FMT), dietary interventions. Results: patients exhibit reduced SCFA-producing bacteria an increase potentially pathogenic genera. Of note, different do not agree common patterns being linked supporting need further, more extensive studies. Dysbiosis sometimes correlates with inflammation disrupted liver function, amplifying neuroinflammatory responses. Key including SCFAs, amyloids, BMAA, may exacerbate neuron promoting protein misfolding, oxidative stress, neuroinflammation. Emerging strategies, probiotics FMT, show restoring balance, although clinical data remain limited. Conclusions: could modulate metabolism ALS. Microbiota-targeted therapies, interventions, represent promising avenues mitigating disease progression. Further research required validate these interventions large-scale, longitudinal develop personalized microbiota-based treatments tailored individual phenotypes.

Language: Английский

Citations

1