bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
The
liver
is
an
important
metastatic
organ
that
contains
many
innate
immune
cells,
yet
little
known
about
their
role
in
anti-metastatic
defense.
We
investigated
how
invariant
natural
killer
T
(iNKT)
cells
influence
colorectal
cancer-derived
metastasis
using
different
models
immunocompetent
mice.
found
hepatic
iNKT
promote
by
creating
a
supportive
niche
for
disseminated
cancer
cells.
Mechanistically,
respond
to
disseminating
producing
the
fibrogenic
cytokines
IL-4
and
IL-13
TCR-independent
manner.
Selective
abrogation
of
sensing
stellate
prevented
transdifferentiation
into
extracellular
matrix-producing
myofibroblasts,
which
hindered
outgrowth
This
study
highlights
novel
tumor-promoting
axis
driven
initial
stages
metastasis.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 26, 2024
Colorectal
cancer
(CRC)
remains
one
of
the
most
prevalent
and
fatal
malignancies
worldwide,
consistently
ranking
among
top
three
in
terms
incidence
mortality.
Despite
notable
advancements
early
detection
therapeutic
interventions,
survival
outcomes
for
advanced-stage
CRC
are
still
dismal,
largely
due
to
issues
such
as
drug
resistance
metastasis.
Recent
research
has
increasingly
implicated
JAK-STAT
signaling
pathway
a
pivotal
contributor
pathogenesis.
This
evolutionarily
conserved
plays
key
role
transmitting
extracellular
signals
nucleus,
thereby
modulating
gene
expression
involved
numerous
fundamental
biological
processes.
In
CRC,
dysregulation
is
frequently
observed
strongly
associated
with
tumor
progression,
including
processes
cellular
proliferation,
apoptosis,
metastasis,
immune
evasion,
sustenance
stem
cells.
Given
its
integral
advancement,
gained
recognition
viable
target.
Extensive
evidence
from
preclinical
clinical
models
supports
efficacy
safety
targeting
components
pathway,
presenting
new
possibilities
patients
particularly
addressing
enhancing
treatment
outcomes.
review
offers
detailed
exploration
focusing
on
regulatory
mechanisms
CRC-related
malignancies.
Moreover,
it
examines
association
between
protein
expression,
features,
prognosis,
potential
management.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(20)
Published: Oct. 1, 2024
Abstract
Distal
metastases
result
from
metastatic
microenvironment
and
tumour
epithelial
cell
interactions,
the
cellular
heterogeneity
of
primary
colorectal
cancer
(CRC)
liver
(LM)
was
evaluated
by
integrating
single‐cell
sequencing
data,
collected
gene
expression
data
subsets
used
to
construct
a
prognostic
model
identify
intercellular
receptor‐ligand
interactions
between
immune
cells
in
CRC
LM.
Multiplex
immunofluorescence
staining,
vitro
wound
healing,
migration
apoptosis
assays
were
performed
further
explore
biological
relevance
identified
potential
regulatory
molecules.
In
this
study,
approximately
17
subtypes
detected,
with
Epi‐11
being
highly
expressed
LM
tissues
compared
samples.
Furthermore,
patients
high
metastasis‐related
genetic
profile
had
poorer
prognosis.
By
predicting
receptor–ligand
found
interact
more
myeloid
T/natural
killer
when
samples,
which
mediated
PLXNB1/SEMA4D
axis.
addition,
SEMA4D
correlated
decreased
overall
survival
CRC,
whereas
PLXNB1
not.
knockdown
prevented
promoted
HCT116
vitro.
summary,
cells,
an
important
subset
may
drive
act
crosstalk
through
signalling
Journal of Cancer Research and Clinical Oncology,
Journal Year:
2024,
Volume and Issue:
150(11)
Published: Nov. 15, 2024
Colorectal
cancer
(CRC)
exhibits
a
substantial
morbidity
and
mortality
rate,
with
its
aetiology
pathogenesis
remain
elusive.
It
holds
significant
importance
within
the
tumour
microenvironment
(TME)
exerts
crucial
regulatory
influence
on
tumorigenesis,
progression,
metastasis.
TAMs
possess
capability
to
foster
CRC
pathogenesis,
proliferation,
invasion,
metastasis,
as
well
angiogenesis,
immune
evasion,
resistance.
Furthermore,
can
mediate
prognosis
of
CRC.
In
this
paper,
we
review
mechanisms
by
which
natural
compounds
target
exert
anti-CRC
effects
from
perspective
promotional
CRC,
mainly
regulating
polarization
TAMs,
reducing
infiltration
recruitment
enhancing
phagocytosis
macrophages,
signalling
pathways
cytokines,
discuss
potential
value
therapeutic
strategies
compounds-targeting
pathway
in
clinical
treatment.
Frontiers in Genetics,
Journal Year:
2024,
Volume and Issue:
15
Published: July 12, 2024
Background
Squamous
cell
carcinomas
(SCCs)
across
different
anatomical
locations
possess
common
molecular
features.
Recent
studies
showed
that
stromal
cells
may
contribute
to
tumor
progression
and
metastasis
of
SCCs.
Limited
by
current
sequencing
technology
analysis
methods,
it
has
been
difficult
combine
stroma
expression
profiles
with
a
large
number
clinical
information.
Methods
With
the
help
transfer
learning
on
line,
single-cell,
bulk
data,
we
identified
validated
2
malignant
gene
patterns
(V1
V5)
expressed
SCCs
from
head
neck
(HNSCC),
lung
(LUSC),
cervix
(CESC),
esophagus,
breast.
Results
Pattern
V5
reflected
novel
feature
explained
mixed
signals
HNSCC
subtypes.
Higher
pattern
was
related
shorter
PFI
gender
cancer-type
specificity.
The
other
V1
associated
poor
in
patients
after
surgery
all
three
squamous
cancer
types
(HNSCC
p
=
0.0055,
LUSC
0.0292,
CESC
0.0451).
Cancer-associated
fibroblasts
could
induce
express
V1.
Adjuvant
radiotherapy
weaken
effect
high
recurrence
metastasis,
depending
radiosensitivity.
Conclusion
Considering
prognostic
value
its
universality,
suggest
genetic
subtype
classification
be
improved
new
system
integrates
both
non-malignant
components.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 19, 2024
The
liver
is
an
important
metastatic
organ
that
contains
many
innate
immune
cells,
yet
little
known
about
their
role
in
anti-metastatic
defense.
We
investigated
how
invariant
natural
killer
T
(iNKT)
cells
influence
colorectal
cancer-derived
metastasis
using
different
models
immunocompetent
mice.
found
hepatic
iNKT
promote
by
creating
a
supportive
niche
for
disseminated
cancer
cells.
Mechanistically,
respond
to
disseminating
producing
the
fibrogenic
cytokines
IL-4
and
IL-13
TCR-independent
manner.
Selective
abrogation
of
sensing
stellate
prevented
transdifferentiation
into
extracellular
matrix-producing
myofibroblasts,
which
hindered
outgrowth
This
study
highlights
novel
tumor-promoting
axis
driven
initial
stages
metastasis.