Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 26, 2024
Colorectal
cancer
(CRC)
remains
one
of
the
most
prevalent
and
fatal
malignancies
worldwide,
consistently
ranking
among
top
three
in
terms
incidence
mortality.
Despite
notable
advancements
early
detection
therapeutic
interventions,
survival
outcomes
for
advanced-stage
CRC
are
still
dismal,
largely
due
to
issues
such
as
drug
resistance
metastasis.
Recent
research
has
increasingly
implicated
JAK-STAT
signaling
pathway
a
pivotal
contributor
pathogenesis.
This
evolutionarily
conserved
plays
key
role
transmitting
extracellular
signals
nucleus,
thereby
modulating
gene
expression
involved
numerous
fundamental
biological
processes.
In
CRC,
dysregulation
is
frequently
observed
strongly
associated
with
tumor
progression,
including
processes
cellular
proliferation,
apoptosis,
metastasis,
immune
evasion,
sustenance
stem
cells.
Given
its
integral
advancement,
gained
recognition
viable
target.
Extensive
evidence
from
preclinical
clinical
models
supports
efficacy
safety
targeting
components
pathway,
presenting
new
possibilities
patients
particularly
addressing
enhancing
treatment
outcomes.
review
offers
detailed
exploration
focusing
on
regulatory
mechanisms
CRC-related
malignancies.
Moreover,
it
examines
association
between
protein
expression,
features,
prognosis,
potential
management.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Colorectal
cancer
(CRC)
progression
and
metastasis
involve
numerous
regulatory
factors.
Among
these,
cellular
retinoic
acid-binding
protein
2
(CRABP2)
has
been
implicated
as
both
a
tumor
activator
suppressor.
Here,
it
is
aimed
to
clarify
the
role
of
CRABP2
in
CRC
growth
explore
underlying
molecular
mechanisms
mediating
its
functions.
Using
vitro
vivo
models,
including
colonocyte-specific
conditional
knockout
mouse
model
(Crabp2ΔIEC)
subcutaneous
tumorigenesis
assay
BALB/c
nude
mice,
shown
that
nuclear
enhances
by
interacting
with
downregulating
suppressor
RB1,
whereas
cytoplasmic
suppresses
liver
AFG3L2
promoting
mitophagy.
In
addition,
AFG3L2-SLC25A39
axis
identified
distinct
mechanism
which
increases
mitochondrial
glutathione
stability
promote
cell
proliferation
independent
RB1
pathway.
Notably,
analysis
tissue
from
patients
reveals
prognostic
implications
functional
roles
dependent
on
subcellular
localization.
Ultimately,
elucidating
CRC,
provide
new
insight
into
disease
pathogenesis
inform
development
therapeutic
interventions.
Frontiers in Genetics,
Journal Year:
2025,
Volume and Issue:
16
Published: May 1, 2025
Colorectal
cancer
(CRC)
is
a
leading
global
with
high
mortality,
especially
in
metastatic
cases,
limited
therapeutic
options.
The
tumor
microenvironment
(TME),
network
comprising
various
immune
cells,
stromal
cells
and
extracellular
(ECM)
components
plays
crucial
role
influencing
progression
therapy
outcome.
genetic
heterogeneity
of
CRC
the
complex
TME
complicates
development
effective,
personalized
treatment
strategies.
prognosis
has
slowly
improved
during
past
decades,
but
(mCRC)
common
among
patients
still
associated
low
survival.
options
for
differ
from
those
mCRC
include
surgery
(mostly
CRC),
chemotherapy,
growth
factor
receptor
signaling
pathway
targeting,
as
well
immunotherapy.
Malignant
are
established
TME,
which
varies
depending
on
primary
or
site.
Herein,
we
review
interactions
several
ECM
3D
models
an
emphasis
how
affects
treatment.
This
comprehensive
summary
provides
support
that
mimic
within
will
be
essential
novel
anticancer
therapies.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 26, 2024
Colorectal
cancer
(CRC)
remains
one
of
the
most
prevalent
and
fatal
malignancies
worldwide,
consistently
ranking
among
top
three
in
terms
incidence
mortality.
Despite
notable
advancements
early
detection
therapeutic
interventions,
survival
outcomes
for
advanced-stage
CRC
are
still
dismal,
largely
due
to
issues
such
as
drug
resistance
metastasis.
Recent
research
has
increasingly
implicated
JAK-STAT
signaling
pathway
a
pivotal
contributor
pathogenesis.
This
evolutionarily
conserved
plays
key
role
transmitting
extracellular
signals
nucleus,
thereby
modulating
gene
expression
involved
numerous
fundamental
biological
processes.
In
CRC,
dysregulation
is
frequently
observed
strongly
associated
with
tumor
progression,
including
processes
cellular
proliferation,
apoptosis,
metastasis,
immune
evasion,
sustenance
stem
cells.
Given
its
integral
advancement,
gained
recognition
viable
target.
Extensive
evidence
from
preclinical
clinical
models
supports
efficacy
safety
targeting
components
pathway,
presenting
new
possibilities
patients
particularly
addressing
enhancing
treatment
outcomes.
review
offers
detailed
exploration
focusing
on
regulatory
mechanisms
CRC-related
malignancies.
Moreover,
it
examines
association
between
protein
expression,
features,
prognosis,
potential
management.
