Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential DOI Creative Commons
Penghui Li, Di Huang

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 26, 2024

Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among top three in terms incidence mortality. Despite notable advancements early detection therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance metastasis. Recent research has increasingly implicated JAK-STAT signaling pathway a pivotal contributor pathogenesis. This evolutionarily conserved plays key role transmitting extracellular signals nucleus, thereby modulating gene expression involved numerous fundamental biological processes. In CRC, dysregulation is frequently observed strongly associated with tumor progression, including processes cellular proliferation, apoptosis, metastasis, immune evasion, sustenance stem cells. Given its integral advancement, gained recognition viable target. Extensive evidence from preclinical clinical models supports efficacy safety targeting components pathway, presenting new possibilities patients particularly addressing enhancing treatment outcomes. review offers detailed exploration focusing on regulatory mechanisms CRC-related malignancies. Moreover, it examines association between protein expression, features, prognosis, potential management.

Language: Английский

Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin‐Mediated Mitophagy DOI Creative Commons
Chen Tian, Sheng Yang, Chuan Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 30, 2025

Colorectal cancer (CRC) progression and metastasis involve numerous regulatory factors. Among these, cellular retinoic acid-binding protein 2 (CRABP2) has been implicated as both a tumor activator suppressor. Here, it is aimed to clarify the role of CRABP2 in CRC growth explore underlying molecular mechanisms mediating its functions. Using vitro vivo models, including colonocyte-specific conditional knockout mouse model (Crabp2ΔIEC) subcutaneous tumorigenesis assay BALB/c nude mice, shown that nuclear enhances by interacting with downregulating suppressor RB1, whereas cytoplasmic suppresses liver AFG3L2 promoting mitophagy. In addition, AFG3L2-SLC25A39 axis identified distinct mechanism which increases mitochondrial glutathione stability promote cell proliferation independent RB1 pathway. Notably, analysis tissue from patients reveals prognostic implications functional roles dependent on subcellular localization. Ultimately, elucidating CRC, provide new insight into disease pathogenesis inform development therapeutic interventions.

Language: Английский

Citations

0

In vitro 3D modeling of colorectal cancer: the pivotal role of the extracellular matrix, stroma and immune modulation DOI Creative Commons

Veroniaina Hanitrarimalala,

Zdenka Prgomet,

My Hedhammar

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: May 1, 2025

Colorectal cancer (CRC) is a leading global with high mortality, especially in metastatic cases, limited therapeutic options. The tumor microenvironment (TME), network comprising various immune cells, stromal cells and extracellular (ECM) components plays crucial role influencing progression therapy outcome. genetic heterogeneity of CRC the complex TME complicates development effective, personalized treatment strategies. prognosis has slowly improved during past decades, but (mCRC) common among patients still associated low survival. options for differ from those mCRC include surgery (mostly CRC), chemotherapy, growth factor receptor signaling pathway targeting, as well immunotherapy. Malignant are established TME, which varies depending on primary or site. Herein, we review interactions several ECM 3D models an emphasis how affects treatment. This comprehensive summary provides support that mimic within will be essential novel anticancer therapies.

Language: Английский

Citations

0

The immunosuppressive role of VSIG4 in colorectal cancer and its interaction with the tumor microenvironment DOI Creative Commons

H-G Zhang,

Wanqing Yao,

Zehao Zhou

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 3, 2025

Language: Английский

Citations

0

Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors DOI Creative Commons
Haoyue Wang,

Sun Kexiang,

Tao Shan

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156224 - 156224

Published: Nov. 23, 2024

Language: Английский

Citations

3

Targeting the JAK-STAT pathway in colorectal cancer: mechanisms, clinical implications, and therapeutic potential DOI Creative Commons
Penghui Li, Di Huang

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Nov. 26, 2024

Colorectal cancer (CRC) remains one of the most prevalent and fatal malignancies worldwide, consistently ranking among top three in terms incidence mortality. Despite notable advancements early detection therapeutic interventions, survival outcomes for advanced-stage CRC are still dismal, largely due to issues such as drug resistance metastasis. Recent research has increasingly implicated JAK-STAT signaling pathway a pivotal contributor pathogenesis. This evolutionarily conserved plays key role transmitting extracellular signals nucleus, thereby modulating gene expression involved numerous fundamental biological processes. In CRC, dysregulation is frequently observed strongly associated with tumor progression, including processes cellular proliferation, apoptosis, metastasis, immune evasion, sustenance stem cells. Given its integral advancement, gained recognition viable target. Extensive evidence from preclinical clinical models supports efficacy safety targeting components pathway, presenting new possibilities patients particularly addressing enhancing treatment outcomes. review offers detailed exploration focusing on regulatory mechanisms CRC-related malignancies. Moreover, it examines association between protein expression, features, prognosis, potential management.

Language: Английский

Citations

2