The Role of Non-coding RNAs in Oncology

Cell, Journal Year: 2019, Volume and Issue: 179(5), P. 1033 - 1055

Published: Nov. 1, 2019

Language: Английский

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Non-coding RNAs in disease: from mechanisms to therapeutics

Nature Reviews Genetics, Journal Year: 2023, Volume and Issue: 25(3), P. 211 - 232

Published: Nov. 15, 2023

Language: Английский

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Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(6), P. 389 - 406

Published: Jan. 25, 2022

Language: Английский

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Roles of transposable elements in the regulation of mammalian transcription

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(7), P. 481 - 497

Published: Feb. 28, 2022

Language: Английский

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Host–transposon interactions: conflict, cooperation, and cooption

Genes & Development, Journal Year: 2019, Volume and Issue: 33(17-18), P. 1098 - 1116

Published: Sept. 1, 2019

Transposable elements (TEs) are mobile DNA sequences that colonize genomes and threaten genome integrity. As a result, several mechanisms appear to have emerged during eukaryotic evolution suppress TE activity. However, TEs ubiquitous account for prominent fraction of most genomes. We argue the evolutionary success cannot be explained solely by evasion from host control mechanisms. Rather, some evolved commensal even mutualistic strategies mitigate cost their propagation. These coevolutionary processes promote emergence complex cellular activities, which in turn pave way cooption organismal function.

Language: Английский

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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications

Nature Cell Biology, Journal Year: 2021, Volume and Issue: 23(4), P. 424 - 436

Published: April 1, 2021

Language: Английский

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PhasiRNAs in Plants: Their Biogenesis, Genic Sources, and Roles in Stress Responses, Development, and Reproduction

The Plant Cell, Journal Year: 2020, Volume and Issue: 32(10), P. 3059 - 3080

Published: Aug. 18, 2020

Abstract Phased secondary small interfering RNAs (phasiRNAs) constitute a major category of in plants, but most their functions are still poorly defined. Some phasiRNAs, known as trans-acting siRNAs, to target complementary mRNAs for degradation and function development. However, the targets or biological roles other phasiRNAs remain speculative. New insights into phasiRNA biogenesis, conservation, variation across flowering plants continue emerge due increased availability plant genomic sequences, deeper more sophisticated sequencing approaches, improvements computational biology biochemical/molecular/genetic analyses. In this review, we survey recent progress biology, with particular focus on two classes associated male reproduction: 21-nucleotide (accumulate early anther ontogeny) 24-nucloetide (produced somatic cells during meiosis) phasiRNAs. We describe function, evolution define unanswered questions that represent topics future research.

Language: Английский

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Noncoding RNAs in Extracellular Fluids as Cancer Biomarkers: The New Frontier of Liquid Biopsies

Cancers, Journal Year: 2019, Volume and Issue: 11(8), P. 1170 - 1170

Published: Aug. 14, 2019

The last two decades of cancer research have been devoted in directions: (1) understanding the mechanism carcinogenesis for an effective treatment, and (2) improving prevention screening early detection disease. This aspect has developed, especially certain types cancers, thanks also to introduction new concepts such as liquid biopsies precision medicine. In this context, there is a growing interest application alternative noninvasive methodologies search biomarkers. frontiers lead RNA molecules circulating body fluids. Searching biomarkers extracellular fluids represents better option patients because they are easier access, less painful, potentially more economical. Moreover, possibility these samples be taken repeatedly, allows monitoring disease progression or treatment efficacy intervention dynamic patient, which fundamental basis personalized molecules, freely packed microvesicles, all characteristics ideal owing their high stability under storage handling conditions being able sampled several times monitoring. demonstrated many plasma/serum levels mirror those primary tumor. There large variety species noncoding proteins that could used biopsies. Among them, most studied microRNAs, but recently attention researcher directed towards Piwi-interacting RNAs, circular other small RNAs. Another class species, long larger than microRNAs very versatile promising group which, apart from use biomarkers, possible therapeutic role. review, we will give overview common detectable provide update concerning situation on

Language: Английский

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Targeting epigenetic regulators to overcome drug resistance in cancers

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Feb. 17, 2023

Abstract Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic regulation a heritable change in gene expressions independent of nucleotide sequence changes. As the common epigenetic mechanisms, DNA methylation, histone modification, non-coding RNA have been well studied. Increasing evidence has shown that aberrant regulations contribute to tumor resistance. Therefore, targeting regulators represents an effective strategy reverse drug In this review, we summarize roles addition, as essential factors modifications, demethylases mediate or genomic modifications. Herein, comprehensively describe functions demethylase family including lysine-specific family, Jumonji C-domain-containing arginine fully discuss their regulatory mechanisms related therapeutic strategies, small-molecule inhibitors small interfering overcome resistance, are also described.

Language: Английский

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Circulating Cell-Free Nucleic Acids: Main Characteristics and Clinical Application

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(18), P. 6827 - 6827

Published: Sept. 17, 2020

Liquid biopsy recently became a very promising diagnostic method that has several advantages over conventional invasive methods. may serve as source of important biomarkers including cell-free nucleic acids (cf-NAs). Cf-DNA is widely used in prenatal testing order to characterize fetal genetic disorders. Analysis cf-DNA provide information about the mutation profile tumor cells, while non-coding RNAs are biomarker candidates diagnosis and prognosis cancer. Many these markers have potential help clinicians therapy selection follow-up patients. Thus, cf-NA-based diagnostics represent new path personalized medicine. Although reviews available field, most them focus on limited number cf-NA types. In this review, we give an overview all known cf-NAs cf-DNA, cf-mtDNA RNA (miRNA, lncRNA, circRNA, piRNA, YRNA, vtRNA) by discussing their biogenesis, biological function liquid biopsy. We also outline possible future directions field.

Language: Английский

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