Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2540 - 2540
Published: Nov. 7, 2024
The
impressive
achievements
made
in
the
last
century
extending
lifespan
have
led
to
a
significant
growth
rate
of
elderly
individuals
populations
across
world
and
an
exponential
increase
incidence
age-related
conditions
such
as
cardiovascular
diseases,
diabetes
mellitus
type
2,
neurodegenerative
diseases.
To
date,
geroscientists
identified
12
hallmarks
aging
(genomic
instability,
telomere
attrition,
epigenetic
alterations,
loss
proteostasis,
impaired
macroautophagy,
mitochondrial
dysfunction,
nutrient
sensing,
cellular
senescence,
stem
cell
exhaustion,
defective
intercellular
communication,
chronic
inflammation,
gut
dysbiosis),
intricately
linked
among
each
other,
which
can
be
targeted
with
senolytic
or
senomorphic
drugs,
well
more
aggressive
approaches
cell-based
therapies.
side
effects
seriously
limit
use
these
drugs.
However,
since
rejuvenation
is
dream
mankind,
future
research
expected
improve
tolerability
available
drugs
highlight
novel
strategies.
In
meantime,
medical
community,
healthcare
providers,
society
should
decide
when
start
treatments
how
tailor
them
individually.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(23)
Published: June 1, 2023
Colorectal
cancer
(CRC)
is
the
most
common
of
digestive
system
with
high
mortality
and
morbidity
rates.
Gut
microbiota
found
in
intestines,
especially
colorectum,
has
structured
crosstalk
interactions
host
that
affect
several
physiological
processes.
The
gut
include
CRC-promoting
bacterial
species,
such
as
Fusobacterium
nucleatum,
Escherichia
coli,
Bacteroides
fragilis,
CRC-protecting
Clostridium
butyricum,
Streptococcus
thermophilus,
Lacticaseibacillus
paracasei,
which
along
other
microorganisms,
viruses
fungi,
play
critical
roles
development
CRC.
Different
features
are
identified
patients
early-onset
CRC,
combined
different
patterns
between
fecal
intratumoral
microbiota.
may
be
beneficial
diagnosis
treatment
CRC;
some
bacteria
serve
biomarkers
while
others
regulators
chemotherapy
immunotherapy.
Furthermore,
metabolites
produced
by
essential
CRC
cells.
Harmful
primary
bile
acids
short-chain
fatty
acids,
whereas
others,
including
ursodeoxycholic
acid
butyrate,
impede
tumor
progression.
This
review
focuses
on
its
metabolites,
their
potential
development,
diagnosis,
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2571 - 2571
Published: Jan. 29, 2023
The
human
circadian
system
has
a
period
of
approximately
24
h
and
studies
on
the
consequences
“chornodisruption”
have
greatly
expanded.
Lifestyle
environmental
factors
modern
societies
(i.e.,
artificial
lighting,
jetlag,
shift
work,
around-the-clock
access
to
energy-dense
food)
can
induce
disruptions
thereby
adversely
affect
individual
health.
Growing
evidence
demonstrates
complex
reciprocal
relationship
between
metabolism
system,
in
which
perturbations
one
other
one.
From
nutritional
genomics
perspective,
genetic
variants
clock
genes
both
influence
metabolic
health
modify
response
diet.
Moreover,
an
interplay
rhythm,
gut
microbiome,
epigenome
been
demonstrated,
with
diet
turn
able
modulate
this
link
suggesting
remarkable
plasticity
underlying
mechanisms.
In
view,
study
impact
timing
eating
by
matching
elements
from
research
chrono-biology,
that
is,
chrono-nutrition,
could
significant
implications
for
personalized
nutrition
terms
reducing
prevalence
burden
chronic
diseases.
This
review
provides
overview
current
interactions
nutrition,
highlighting
how
microbiome.
addition,
possible
strategies
manage
circadian-aligned
feeding
are
suggested.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 15, 2024
Abstract
Ageing
is
often
characterised
by
progressive
accumulation
of
damage,
and
it
one
the
most
important
risk
factors
for
chronic
disease
development.
Epigenetic
mechanisms
including
DNA
methylation
could
functionally
contribute
to
organismal
aging,
however
key
functions
biological
processes
may
govern
ageing
are
still
not
understood.
Although
age
predictors
called
epigenetic
clocks
can
accurately
estimate
an
individual
based
on
cellular
methylation,
their
models
have
limited
ability
explain
prediction
algorithm
behind
underlying
controlling
ageing.
Here
we
present
XAI-AGE,
a
biologically
informed,
explainable
deep
neural
network
model
accurate
across
multiple
tissue
types.
We
show
that
XAI-AGE
outperforms
first-generation
achieves
similar
results
learning-based
models,
while
opening
up
possibility
infer
meaningful
insights
activity
pathways
other
abstract
directly
from
model.
European Heart Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 8, 2025
Abstract
Background
and
Aims
To
identify
the
patterns
of
coffee
drinking
timing
in
US
population
evaluate
their
associations
with
all-cause
cause-specific
mortality.
Methods
This
study
included
40
725
adults
from
National
Health
Nutrition
Examination
Survey
1999–2018
who
had
complete
information
on
dietary
data
1463
Women’s
Men’s
Lifestyle
Validation
Study
7-day
record.
Clustering
analysis
was
used
to
timing.
Results
In
this
observational
study,
two
distinct
[morning
type
(36%
participants)
all-day-type
(14%
participants)]
were
identified
validated
Study.
During
a
median
(interquartile
range)
follow-up
9.8
(9.1)
years,
total
4295
deaths,
1268
cardiovascular
disease
934
cancer
deaths
recorded.
After
adjustment
for
caffeinated
decaffeinated
intake
amounts,
sleep
hours,
other
confounders,
morning-type
pattern,
rather
than
significantly
associated
lower
risks
(hazard
ratio:
.84;
95%
confidential
interval:
.74–.95)
disease-specific
.69;
.55–.87)
mortality
as
compared
non-coffee
drinking.
Coffee
modified
association
between
amounts
(P-interaction
=
.031);
higher
risk
participants
pattern
but
not
those
pattern.
Conclusions
Drinking
morning
may
be
more
strongly
later
day.
