Nutrients,
Journal Year:
2023,
Volume and Issue:
15(22), P. 4772 - 4772
Published: Nov. 13, 2023
Lipid
metabolic
diseases
have
substantial
morbidity
and
mortality
rates,
posing
a
significant
threat
to
human
health.
PPARα,
member
of
the
peroxisome
proliferator-activated
receptors
(PPARs),
plays
crucial
role
in
lipid
metabolism
immune
regulation.
Recent
studies
increasingly
recognized
pivotal
involvement
PPARα
diverse
pathological
conditions.
This
comprehensive
review
aims
elucidate
multifaceted
including
liver
diseases,
diabetes-related
age-related
cancers,
shedding
light
on
underlying
molecular
mechanisms
some
regulatory
effects
natural/synthetic
ligands
PPARα.
By
summarizing
latest
research
findings
we
aim
provide
foundation
for
possible
therapeutic
exploitation
diseases.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Dec. 16, 2022
Aging
is
a
gradual
and
irreversible
pathophysiological
process.
It
presents
with
declines
in
tissue
cell
functions
significant
increases
the
risks
of
various
aging-related
diseases,
including
neurodegenerative
cardiovascular
metabolic
musculoskeletal
immune
system
diseases.
Although
development
modern
medicine
has
promoted
human
health
greatly
extended
life
expectancy,
aging
society,
variety
chronic
diseases
have
gradually
become
most
important
causes
disability
death
elderly
individuals.
Current
research
on
focuses
elucidating
how
endogenous
exogenous
stresses
(such
as
genomic
instability,
telomere
dysfunction,
epigenetic
alterations,
loss
proteostasis,
compromise
autophagy,
mitochondrial
cellular
senescence,
stem
exhaustion,
altered
intercellular
communication,
deregulated
nutrient
sensing)
participate
regulation
aging.
Furthermore,
thorough
pathogenesis
to
identify
interventions
that
promote
longevity
caloric
restriction,
microbiota
transplantation,
nutritional
intervention)
clinical
treatment
methods
for
(depletion
senescent
cells,
therapy,
antioxidative
anti-inflammatory
treatments,
hormone
replacement
therapy)
could
decrease
incidence
turn
healthy
longevity.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Nov. 7, 2022
Abstract
Aging
is
accompanied
by
the
decline
of
organismal
functions
and
a
series
prominent
hallmarks,
including
genetic
epigenetic
alterations.
These
aging-associated
changes
include
DNA
methylation,
histone
modification,
chromatin
remodeling,
non-coding
RNA
(ncRNA)
regulation,
all
which
participate
in
regulation
aging
process,
hence
contribute
to
aging-related
diseases.
Therefore,
understanding
mechanisms
will
provide
new
avenues
develop
strategies
delay
aging.
Indeed,
interventions
based
on
manipulating
have
led
alleviation
or
extension
lifespan
animal
models.
Small
molecule-based
therapies
reprogramming
that
enable
rejuvenation
been
developed
for
ameliorating
reversing
conditions.
In
addition,
adopting
health-promoting
activities,
such
as
caloric
restriction,
exercise,
calibrating
circadian
rhythm,
has
demonstrated
Furthermore,
various
clinical
trials
intervention
are
ongoing,
providing
more
evidence
safety
efficacy
these
therapies.
Here,
we
review
recent
work
outline
advances
age-associated
A
better
critical
roles
epigenetics
process
lead
prevention
human
therapy
Cell,
Journal Year:
2023,
Volume and Issue:
186(2), P. 287 - 304.e26
Published: Jan. 1, 2023
Whether
and
how
certain
transposable
elements
with
viral
origins,
such
as
endogenous
retroviruses
(ERVs)
dormant
in
our
genomes,
can
become
awakened
contribute
to
the
aging
process
is
largely
unknown.
In
human
senescent
cells,
we
found
that
HERVK
(HML-2),
most
recently
integrated
ERVs,
are
unlocked
transcribe
genes
produce
retrovirus-like
particles
(RVLPs).
These
RVLPs
constitute
a
transmissible
message
elicit
senescence
phenotypes
young
which
be
blocked
by
neutralizing
antibodies.
The
activation
of
ERVs
was
also
observed
organs
aged
primates
mice
well
tissues
serum
from
elderly.
Their
repression
alleviates
cellular
tissue
degeneration
and,
some
extent,
organismal
aging.
findings
indicate
resurrection
hallmark
driving
force
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
ACS Chemical Neuroscience,
Journal Year:
2023,
Volume and Issue:
15(1), P. 1 - 30
Published: Dec. 14, 2023
Aging
is
a
dynamic,
time-dependent
process
that
characterized
by
gradual
accumulation
of
cell
damage.
Continual
functional
decline
in
the
intrinsic
ability
living
organisms
to
accurately
regulate
homeostasis
leads
increased
susceptibility
and
vulnerability
diseases.
Many
efforts
have
been
put
forth
understand
prevent
effects
aging.
Thus,
major
cellular
molecular
hallmarks
aging
identified,
their
relationships
age-related
diseases
malfunctions
explored.
Here,
we
use
data
from
CAS
Content
Collection
analyze
publication
landscape
recent
aging-related
research.
We
review
advances
knowledge
delineate
trends
research
advancements
on
factors
attributes
across
time
geography.
also
current
concepts
related
molecular,
cellular,
organismic
level,
age-associated
diseases,
with
attention
brain
health,
as
well
biochemical
processes
associated
Major
outlined,
correlations
features
are
hope
this
will
be
helpful
for
apprehending
field
mechanisms
progression,
an
effort
further
solve
remaining
challenges
fulfill
its
potential.
The Innovation,
Journal Year:
2023,
Volume and Issue:
4(1), P. 100380 - 100380
Published: Jan. 1, 2023
•An
atlas
of
age-,
tissue-,
and
cell-type-specific
benefits
long-term
exercise.•Exercise
protects
tissues
from
infectious
injury,
especially
in
younger
ones.•Exercise
promotes
rejuvenation
aged
tissues,
the
nervous
system.•Exercise
exerts
geroprotective
effects,
by
resetting
circadian
programs
via
clock
protein
BMAL1.
Exercise
whole
organism,
yet,
how
across
body
orchestrally
respond
to
exercise
remains
enigmatic.
Here,
young
old
mice,
with
or
without
exercise,
exposed
we
characterized
phenotypic
molecular
adaptations
a
12-month
14
tissues/organs
at
single-cell
resolution.
Overall,
although
more
effectively
animals,
individuals
terms
inflammaging
suppression
tissue
rejuvenation,
structural
improvement
central
system
systemic
vasculature
being
most
prominent.
In
vascular
endothelial
cells,
found
that
readjusting
rhythmic
machinery
core
BMAL1
delayed
senescence
facilitated
recovery
damage,
recapitulating
beneficial
effects
exercise.
Our
study
underscores
effect
reconstituting
youthful
network
provides
foundation
for
further
investigating
interplay
between
aging,
immune
challenges
organism.
