Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary

JCI Insight, Journal Year: 2020, Volume and Issue: 5(1)

Published: Jan. 15, 2020

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate adaptive responses — ranging from leukocyte mobilization, trafficking, chemotaxis to cytokine release T cell differentiation —are mediated time of day–dependent manner. The National Institutes Health (NIH) recently sponsored an interdisciplinary workshop, “Sleep Insufficiency, Circadian Misalignment, the Immune Response,” highlight new research linking biology function identify areas high translational potential. This Review summarizes topics discussed highlights immediate opportunities delineating clinically relevant connections among biological rhythms, sleep, regulation.

Language: Английский

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Circadian Expression of Migratory Factors Establishes Lineage-Specific Signatures that Guide the Homing of Leukocyte Subsets to Tissues

Immunity, Journal Year: 2018, Volume and Issue: 49(6), P. 1175 - 1190.e7

Published: Dec. 1, 2018

The number of leukocytes present in circulation varies throughout the day, reflecting bone marrow output and emigration from blood into tissues. Using an organism-wide circadian screening approach, we detected oscillations pro-migratory factors that were distinct for specific vascular beds individual leukocyte subsets. This rhythmic molecular signature governed time-of-day-dependent homing behavior subsets to organs. Ablation BMAL1, a transcription factor central clock function, endothelial cells or demonstrated recruitment is dependent on both microenvironmental cell-autonomous oscillations. These oscillatory patterns defined trafficking homeostasis inflammation determined detectable tumor burden cancer models. Rhythms expression migration capacities preserved human primary leukocytes. definition spatial temporal profiles guiding organs provides resource further study impact rhythms immunity.

Language: Английский

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Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis

Nature, Journal Year: 2019, Volume and Issue: 574(7777), P. 254 - 258

Published: Sept. 18, 2019

Language: Английский

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Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution?

Frontiers in Cardiovascular Medicine, Journal Year: 2019, Volume and Issue: 6

Published: March 18, 2019

Inflammation not only plays a crucial role in acute ischemic cardiac injury, but also contributes to post-infarction repair and remodeling. Traditionally, neutrophils have been merely considered as detrimental the setting of an myocardial infarction. However, recently published studies demonstrated that might play important by regulating reparative processes. An emerging concept is different neutrophil subsets exist, which exhibit separate functional properties. In support existence distinct heart, transcriptional changes reported within first few days after addition, there increasing awareness gender-specific differences many physiological pathophysiological responses, including cardiovascular parameters inflammation. Of particular interest this context are recent experimental data dissecting sex-specific signaling Unraveling possibly stage-dependent properties may provide new therapeutic strategies order improve clinical outcome for infarction patients. This review will briefly discuss advances our understanding repertoire insights post-myocardial inflammatory responses.

Language: Английский

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Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: June 24, 2020

Abstract Breast cancer is the most common type of worldwide and one major causes death in women. Epidemiological studies have established a link between night-shift work increased risk, suggesting that circadian disruption may play role carcinogenesis. Here, we aim to shed light on effect chronic jetlag (JL) mammary tumour development. To do this, use mouse model spontaneous tumourigenesis subject it disruption. We observe significantly increases cancer-cell dissemination lung metastasis. It also enhances stemness tumour-initiating potential cells creates an immunosuppressive shift microenvironment. Finally, our results suggest CXCR2 inhibitor could correct JL Altogether, data provide conceptual framework better understand manage effects breast progression.

Language: Английский

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The relevance of daylight for humans

Biochemical Pharmacology, Journal Year: 2020, Volume and Issue: 191, P. 114304 - 114304

Published: Oct. 28, 2020

Daylight is ubiquitous and crucial for mammalian vision as well non-visual input to the brain via intrinsically photosensitive retinal ganglion cells (ipRGCs) that express photopigment melanopsin. The ipRGCs project circadian clock in suprachiasmatic nuclei thereby ensure entrainment 24-hour day-night cycle, changes daylength trigger appropriate seasonal behaviours. also perihabenular nucleus surrounding regions modulate mood, stress learning animals humans. Given light has strong direct effects on cognition, alertness, performance, sleep, can be considered a "drug" treat many clinical conditions. Light therapy already established winter other depressions sleep disorders. Beyond visual retina, daylight contributes prevent myopia young by its impact eye development, important Vitamin D synthesis bone health skin. sun most powerful source and, dependent dose, ultraviolet radiance toxic living organisms used disinfectant. Most research involves laboratory-based electric light, without dynamic spectral undergoes moment moment. There gap between importance of human beings amount being done this subject. taken granted an environmental factor, enjoyed or avoided, according More awareness architecture urban design beyond aesthetic values comfort may lead higher quality work environments. Although we do not yet have factual basis assumption natural overall "better" than debate mandates serious consideration sunlight just solar power but biologically necessary sustainable healthy living.

Language: Английский

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Dendritic cells direct circadian anti-tumour immune responses

Nature, Journal Year: 2022, Volume and Issue: 614(7946), P. 136 - 143

Published: Dec. 5, 2022

Abstract The process of cancer immunosurveillance is a mechanism tumour suppression that can protect the host from development throughout its lifetime 1,2 . However, it unknown whether effectiveness fluctuates over single day. Here we demonstrate initial time day engraftment dictates ensuing size across mouse models. Using immunodeficient mice as well lacking lineage-specific circadian functions, show dendritic cells (DCs) and CD8 + T exert anti-tumour functions control melanoma volume. Specifically, find rhythmic trafficking DCs to draining lymph node governs response tumour-antigen-specific dependent on expression co-stimulatory molecule CD80. As consequence, immunotherapy more effective when synchronized with DC shows outcomes in suggests similar effects humans. These data rhythms immune components are not only critical for controlling but also be therapeutic relevance.

Language: Английский

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The circadian immune system

Science Immunology, Journal Year: 2022, Volume and Issue: 7(72)

Published: June 3, 2022

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were first to identify responses be under a circadian control. Only last decade, however, have molecular factors governing rhythms been identified. These revealed complex picture of interconnectivity rhythmicity within cells with that their environment. Here, we provide global overview system, focusing on recent advances rapidly expanding field immunology.

Language: Английский

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Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2021, Volume and Issue: 18(10), P. 679 - 689

Published: May 17, 2021

Language: Английский

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Exercise sustains the hallmarks of health

Journal of sport and health science/Journal of Sport and Health Science, Journal Year: 2022, Volume and Issue: 12(1), P. 8 - 35

Published: Oct. 29, 2022

Exercise has long been known for its active role in improving physical fitness and sustaining health. Regular moderate-intensity exercise improves all aspects of human health is widely accepted as a preventative therapeutic strategy various diseases. It well-documented that maintains restores homeostasis at the organismal, tissue, cellular, molecular levels to stimulate positive physiological adaptations consequently protect against pathological conditions. Here we mainly summarize how affects major hallmarks health, including integrity barriers, containment local perturbations, recycling turnover, integration circuitries, rhythmic oscillations, homeostatic resilience, hormetic regulation, well repair regeneration. Furthermore, current understanding mechanisms responsible beneficial response exercise. This review aimed providing comprehensive summary vital biological through which opens window application other interventions. We hope continuing investigation this field will further increase our processes involved thus get us closer identification new therapeutics improve quality life.

Language: Английский

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