The Chicken Embryo Model: A Novel and Relevant Model for Immune-Based Studies DOI Creative Commons
Paul Garcia, Yan Wang, Jean Viallet

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Nov. 19, 2021

Dysregulation of the immune system is associated with many pathologies, including cardiovascular diseases, diabetes, and cancer. To date, most commonly used models in biomedical research are rodents, despite various advantages they offer, their use also raises numerous drawbacks. Recently, another vivo model, chicken embryo its chorioallantoic membrane, has re-emerged for applications. This model benefits compared to other classical models, as it cost-effective, time-efficient, easier use. In this review, we explain how can be a immune-based studies, gradually develops an embryonic system, yet which functionally similar humans’. We mainly aim describe avian highlighting differences similarities human repertoire lymphoid tissues, cells, key features. general ovo ontogeny. conclusion, expect that review will help future studies better tailor testing specific experimental hypotheses or performing preclinical testing.

Language: Английский

Cytokines and Chemokines Involved in Osteoarthritis Pathogenesis DOI Open Access
Vilim Molnar, Vid Matišić, Ivan Kodvanj

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(17), P. 9208 - 9208

Published: Aug. 26, 2021

Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as disease the joint cartilage, osteoarthritis affects all tissues equally. The pathogenesis this degenerative process not completely understood; however, low-grade inflammation leading an imbalance between anabolic and katabolic processes well-established factor. complex network cytokines regulating these cell communication has central role in development progression osteoarthritis. Concentrations both proinflammatory anti-inflammatory were found be altered depending on stage activity. In review, we analyzed individual involved immune with emphasis their function

Language: Английский

Citations

377
T cells in health and disease DOI Creative Commons
Lina Sun, Yanhong Su, Anjun Jiao

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: June 19, 2023

T cells are crucial for immune functions to maintain health and prevent disease. cell development occurs in a stepwise process the thymus mainly generates CD4

Language: Английский

Citations

359
Cellular and molecular mechanisms of skin wound healing DOI
Oscar A Peña, Paul Martin

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(8), P. 599 - 616

Published: March 25, 2024

Language: Английский

Citations

322
The Immune Response in Multiple Sclerosis DOI

Sofía Rodríguez Murúa,

Mauricio Farez, Francisco J. Quintana

et al.

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2021, Volume and Issue: 17(1), P. 121 - 139

Published: Oct. 4, 2021

Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS characterized by immune dysregulation, which results in infiltration of CNS cells, triggering demyelination, axonal damage, neurodegeneration. Although exact causes are not fully understood, genetic environmental factors thought to control onset progression. In this article, we review main immunological mechanisms involved pathogenesis.

Language: Английский

Citations

218
The emerging roles of γδ T cells in cancer immunotherapy DOI
Sofia Mensurado, Rafael Blanco-Domínguez, Bruno Silva‐Santos

et al.

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(3), P. 178 - 191

Published: Jan. 9, 2023

Language: Английский

Citations

198
The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity DOI Creative Commons
Yuan Xiong, Bobin Mi, Ze Lin

et al.

Military Medical Research, Journal Year: 2022, Volume and Issue: 9(1)

Published: Nov. 19, 2022

Abstract Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting variety of cell types, whose activity interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding immune microenvironment processes governing bone, regeneration, clinical translation these mechanisms remains challenge. Regulation increasingly becoming favorable target regeneration; therefore, an in-depth communication between cells functional would valuable. Herein, we review regulatory role promotion maintenance stem states context repair regeneration. We discuss roles various subsets introduce novel strategies, example, biomaterial-targeting activity, aimed at regulating healing. Understanding crosstalk pathways may shed light on new therapeutic opportunities enhancing through regulation microenvironment.

Language: Английский

Citations

174
Function of γδ T cells in tumor immunology and their application to cancer therapy DOI Creative Commons
Jang Hyun Park, Heung Kyu Lee

Experimental & Molecular Medicine, Journal Year: 2021, Volume and Issue: 53(3), P. 318 - 327

Published: March 1, 2021

Abstract T cells of the γδ lineage are unconventional with functions not restricted to MHC-mediated antigen presentation. Because their broad specificity and NK-like cytotoxicity, T-cell importance in tumor immunology has been emphasized. However, some subsets, especially those expressing IL-17, immunosuppressive or tumor-promoting cells. Their cytokine profile cytotoxicity seemingly determined by cross-talk microenvironment components, γδTCR chain. Furthermore, much about TCR remains unknown compared extreme diversity chain pairs. Thus, investigation application have relatively difficult. Nevertheless, remain attractive targets for antitumor therapy because independence from MHC molecules. ability evade immune system through shedding, heterogeneous antigens, low spreading, MHC-independent represent good alternative immunotherapy. Therefore, many approaches using attempted, including induction endogenous cell activation, adoptive transfer expanded ex vivo, utilization chimeric receptor (CAR)-T Here, we discuss function cancer therapy.

Language: Английский

Citations

137
γδ T cells: origin and fate, subsets, diseases and immunotherapy DOI Creative Commons
Yi Hu,

Qinglin Hu,

Yongsheng Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 22, 2023

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering use allogeneic Vδ2

Language: Английский

Citations

111
T Cell Responses to the Microbiota DOI
Ivaylo I. Ivanov, Timur Tuganbaev, Ashwin N. Skelly

et al.

Annual Review of Immunology, Journal Year: 2022, Volume and Issue: 40(1), P. 559 - 587

Published: Feb. 3, 2022

The immune system employs recognition tools to communicate with its microbial evolutionary partner. Among all the methods of perception, T cells enable widest spectrum resolution, ranging from crudest detection whole groups microbes finest specific antigens. application this capability crucial task combatting infections has been focus classical immunology. We now appreciate that coevolution and microbiota led development a lush immunological decision tree downstream recognition, which an inflammatory response is but one branch. In review we discuss known cell-microbe interactions in gut place them context algorithmic framework context-dependent interpretation, circuits across multiple levels resolution. malleability presents opportunity edit cellularity, identity, functionality by utilizing microbiota-controlled pathways promote human health.

Language: Английский

Citations

82
Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T DOI Creative Commons
Qiaofei Liu, Jiayi Li,

Huaijin Zheng

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Feb. 7, 2023

Abstract In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical immunotherapy. However, both show limited efficacies most solid neoplasms, which necessitates the exploration of new immunotherapeutic modalities. The failure CAR-T several neoplasms is attributed to multiple factors, including low antigenicity tumor cells, infiltration effector diverse mechanisms immunosuppression microenvironment. New adoptive therapies have been attempted for TCR-T, CAR-natural killer cells (CAR-NK), CAR-macrophages (CAR-M). Compared CAR-T, these certain advantages treating neoplasms. this review, we summarized 40-year evolution therapies, then focused on advances CAR-NK, CAR-M discussed their potential applications.

Language: Английский

Citations

67