Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(6), P. 1912 - 1924
Published: Feb. 2, 2024
Language: Английский
Nature reviews. Immunology, Journal Year: 2022, Volume and Issue: 23(3), P. 159 - 173
Published: July 25, 2022
Language: Английский
Citations
577
Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11
Published: Nov. 4, 2021
As a complex multicellular structure of the vascular system at central nervous (CNS), blood-brain barrier (BBB) separates CNS from circulation and regulates influx efflux substances to maintain steady-state environment CNS. Lipopolysaccharide (LPS), cell wall component Gram-negative bacteria, can damage function BBB further promote occurrence development sepsis-associated encephalopathy (SAE). Here, we conduct literature review direct indirect mechanisms LPS relationship between these processes SAE. We believe that after destroys BBB, large number inflammatory factors neurotoxins will enter brain tissue, which activate immune cells mediate response in turn BBB. This vicious circle ultimately lead progression Finally, present succinct overview treatment SAE by restoring summarize novel opportunities controlling targeting
Language: Английский
Citations
162
Current Opinion in Neurobiology, Journal Year: 2022, Volume and Issue: 75, P. 102575 - 102575
Published: June 9, 2022
Language: Английский
Citations
128
Protein & Cell, Journal Year: 2023, Volume and Issue: 14(10), P. 762 - 775
Published: May 11, 2023
Abstract The gut microbiota has been found to interact with the brain through microbiota–gut–brain axis, regulating various physiological processes. In recent years, impacts of on neurodevelopment this axis have increasingly appreciated. is commonly considered regulate three pathways, immune pathway, neuronal and endocrine/systemic overlaps crosstalks in between. Accumulating studies identified role neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity Rett Syndrome. Numerous researchers examined pathophysiological mechanisms influenced by (NDDs). This review aims provide a comprehensive overview advancements research pertaining microbiota-gut-brain NDDs. Furthermore, we analyzed both current state progress discuss future perspectives field.
Language: Английский
Citations
126
Brain Behavior and Immunity, Journal Year: 2022, Volume and Issue: 108, P. 245 - 254
Published: Dec. 6, 2022
Autism spectrum disorder (ASD) is a highly heterogeneous neurodevelopmental characterized by communication and social behavior deficits. The presence of restricted repetitive behaviors often accompanies these deficits, characteristics can range from mild to severe. past several decades have seen significant rise in the prevalence ASD. etiology ASD remains unknown; however, genetic environmental risk factors play role. Multiple hypotheses converge suggest that neuroinflammation, or at least interaction between immune neural systems, may be involved some cases groups. Repeated evidence innate dysfunction has been ASD, associated with worsening behaviors. This includes data circulating myeloid cells brain resident macrophages/microglia both human animal models. comprehensive review presents recent findings including aberrant cellular function, microglia activation.
Language: Английский
Citations
123
Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 425 - 445
Published: April 18, 2022
Mounting evidence indicates that microglia, which are the resident immune cells of brain, play critical roles in a diverse array neurodevelopmental processes required for proper brain maturation and function. This has ultimately led to growing speculation microglial dysfunction may role disorder (NDD) pathoetiology. In this review, we first provide an overview how microglia mechanistically contribute sculpting developing neuronal circuits. To example disruption biology impacts NDD development, also highlight emerging linked dysregulation autism spectrum pathogenesis. recent years, there been increasing interest gut microbiome shapes biology. last section put spotlight on burgeoning area research discuss microbiota-dependent modulation is currently thought influence progression.
Language: Английский
Citations
98
Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)
Published: Oct. 6, 2022
Abstract Alzheimer's disease (AD) is the most common neurodegenerative in elderly globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key contributor to onset and progression of AD, however, mechanisms that mediate remain largely unknown. Recent studies have suggested mitochondrial dysfunction including DNA (mtDNA) damage, metabolic defects, quality control (QC) disorders precedes microglial activation subsequent neuroinflammation. Therefore, an in-depth understanding relationship between AD important unveil pathogenesis develop effective approaches for early diagnosis treatment. In this review, we summarized current progress roles mtDNA, metabolism, QC changes provide comprehensive thoughts targeting mitochondria potential therapeutic strategies AD.
Language: Английский
Citations
90
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2449 - 2449
Published: Feb. 23, 2022
The autonomic nervous system (ANS) and the immune are deeply interrelated. ANS regulates both innate adaptive immunity through sympathetic parasympathetic branches, an imbalance in this can determine altered inflammatory response as typically observed chronic conditions such systemic autoimmune diseases. Rheumatoid arthritis, lupus erythematosus, sclerosis all show a dysfunction of that is mutually related to increase inflammation cardiovascular risk. Moreover, interaction between gut microbiota has direct effects on homeostasis. Recently vagal stimulation techniques have emerged unprecedented possibility reduce dysfunction, especially diseases characterized by pain decreased quality life well inflammation.
Language: Английский
Citations
85
Cell Host & Microbe, Journal Year: 2022, Volume and Issue: 30(7), P. 944 - 960.e8
Published: June 1, 2022
Language: Английский
Citations
84
Frontiers in Neuroscience, Journal Year: 2023, Volume and Issue: 17
Published: April 13, 2023
Epidemiological evidence suggests that one’s risk of being diagnosed with a neurodevelopmental disorder (NDD)—such as autism, ADHD, or schizophrenia—increases significantly if their mother had viral bacterial infection during the first second trimester pregnancy. Despite this well-known data, little is known about how developing neural systems are perturbed by events such early-life immune activation. One theory maternal response disrupts processes important for typical fetal and postnatal development, which can subsequently result in specific overlapping behavioral phenotypes offspring, characteristic NDDs. As such, rodent models activation (MIA) have been useful elucidating mechanisms may become dysregulated MIA. This review will start an up-to-date in-depth, critical summary epidemiological data humans, examining association between different types MIA NDD outcomes offspring. Thereafter, we summarize common discuss relevance to human data. Finally, highlight other factors interact impact its associated NDDs, emphasize importance researchers consider these when designing future studies. These points include: sex developmental timing challenge, contribute individual variability responses MIA, genetics, parental age, gut microbiome, prenatal stress, placental buffering.
Language: Английский
Citations
52