Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: Feb. 4, 2025
Attention
deficit
hyperactivity
disorder
(ADHD)
is
a
common
neurodevelopmental
disorder,
which
characterized
by
inattention,
impulsivity
and
hyperactivity.
Although
the
etiology
pathogenesis
of
ADHD
are
not
fully
understood,
existing
studies
have
shown
that
it
may
be
related
to
genetic
factors,
environmental
abnormal
brain
development,
psychosocial
factors.
In
recent
years,
with
concept
microbioa-gut-brain
axis
(MGBA),
more
begun
pay
attention
effect
gut
microbiota
on
ADHD.
Dietary
structure
can
significantly
change
diversity
abundance
microbiota.
Therefore,
dietary
supplements
or
food
additives
regulate
become
one
potential
ways
treat
Peppers,
as
an
important
component,
value
in
regulating
Among
them,
capsaicin
(8-methyl
N-vanillyl-6-noneamide,
CAP),
key
active
component
peppers,
has
been
therapeutic
effects
central
nervous
system
(CNS)
diseases
such
Parkinson’s
disease,
epilepsy,
depression.
addition,
much
paid
beneficial
CAP
Chili
peppers
contain
only
CAP,
but
also
rich
vitamin
C
fatty
acids,
all
ameliorate
modulating
This
finding
provides
treatment
for
ADHD,
new
perspective
expand
research
clinical
pathogenesis.
current
chili
still
at
early
stage
requires
further
verification
through
larger-scale
rigorous
controlled
studies,
its
cannot
ignored.
Life,
Journal Year:
2024,
Volume and Issue:
14(5), P. 559 - 559
Published: April 26, 2024
The
gastrointestinal
tract
is
home
to
trillions
of
diverse
microorganisms
collectively
known
as
the
gut
microbiota,
which
play
a
pivotal
role
in
breaking
down
undigested
foods,
such
dietary
fibers.
Through
fermentation
these
food
components,
short-chain
fatty
acids
(SCFAs)
acetate,
propionate,
and
butyrate
are
produced,
offering
numerous
health
benefits
host.
production
absorption
SCFAs
occur
through
various
mechanisms
within
human
intestine,
contingent
upon
types
fibers
reaching
specific
engaged
fermentation.
Medical
literature
extensively
documents
supplementation
SCFAs,
particularly
butyrate,
treatment
gastrointestinal,
metabolic,
cardiovascular,
gut-brain-related
disorders.
This
review
seeks
provide
an
overview
dynamics
involved
gut.
Additionally,
it
will
focus
on
roles
promoting
metabolic
health,
well
their
current
therapeutic
implications.
Biomimetics,
Journal Year:
2025,
Volume and Issue:
10(2), P. 73 - 73
Published: Jan. 24, 2025
The
gut
microbiota
is
a
complex
and
dynamic
ecosystem
that
plays
fundamental
role
in
human
health
by
regulating
immunity,
metabolism,
the
gut–brain
axis.
Beyond
its
critical
physiological
functions,
it
has
emerged
as
rich
source
of
inspiration
for
biomimetic
innovations
healthcare
biotechnology.
This
review
explores
transformative
potential
microbiota-based
biomimetics,
focusing
on
key
biological
mechanisms
such
resilience,
self-regulation,
quorum
sensing.
These
have
inspired
development
innovative
applications,
including
personalized
probiotics,
synbiotics,
artificial
microbiomes,
bioinspired
biosensors,
bioremediation
systems.
Such
technologies
aim
to
emulate
optimize
intricate
functions
microbial
ecosystems,
addressing
challenges
environmental
sustainability.
integration
advanced
technologies,
intelligence,
bioengineering,
multi-omics
approaches,
further
accelerated
biomimetics.
tools
enable
precision
therapies
tailored
individual
profiles,
enhance
efficacy
diagnostic
systems,
facilitate
design
environmentally
sustainable
solutions,
waste-to-energy
systems
platforms.
Emerging
areas
innovation,
gut-on-chip
models
synthetic
biology,
offer
unprecedented
opportunities
studying
applying
principles
controlled
environments.
Despite
these
advancements,
remain.
replication
complexity
environments,
ethical
concerns
regarding
genetically
engineered
microorganisms,
equitable
access
are
hurdles
must
be
addressed.
underscores
importance
interdisciplinary
collaboration
public
awareness
overcoming
barriers
ensuring
responsible
solutions.
By
leveraging
biomimetics
represents
promising
frontier
approach
revolutionize
therapeutic
strategies,
redefine
tools,
address
global
challenges,
paving
way
more
personalized,
efficient,
future
medicine
Protein & Cell,
Journal Year:
2023,
Volume and Issue:
14(10), P. 709 - 712
Published: May 23, 2023
With
its
critical
role
in
human
health
and
disease,
the
microbiome
has
transformed
modern
biology.
Over
past
few
years,
research
evolved
rapidly,
with
microbiologists
gradually
shifting
their
focus
from
cataloging
microorganisms
to
understanding
functional
roles
how
they
interact
host.
Here,
we
present
global
trends
summarize
current
work
on
published
Protein
&
Cell.
In
closing,
highlight
some
of
major
advancements
research,
including
technical,
practical,
conceptual
advancements,
that
aim
enhance
disease
diagnosis,
medicine
development,
personalized
interventions
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 20, 2024
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
177, P. 117031 - 117031
Published: June 25, 2024
An
expanding
body
of
research
indicates
a
correlation
between
the
gut
microbiota
and
various
diseases.
Metabolites
produced
by
act
as
mediators
host,
interacting
with
multiple
systems
in
human
to
regulate
physiological
or
pathological
functions.
However,
further
investigation
is
still
required
elucidate
underlying
mechanisms.
One
such
metabolite
involved
choline
metabolism
microbes
trimethylamine
(TMA),
which
can
traverse
intestinal
epithelial
barrier
enter
bloodstream,
ultimately
reaching
liver
where
it
undergoes
oxidation
catalyzed
flavin-containing
monooxygenase
3
(FMO3)
form
N-oxide
(TMAO).
While
some
TMAO
eliminated
through
renal
excretion,
remaining
amounts
circulate
leading
systemic
inflammation,
endoplasmic
reticulum
(ER)
stress,
mitochondrial
disruption
normal
functions
humans.
As
representative
microbial
originating
from
gut,
has
significant
potential
both
biomarker
for
monitoring
disease
occurrence
progression
tailoring
personalized
treatment
strategies
patients.
This
review
provides
an
extensive
overview
sources
its
blood,
well
impact
on
several
major
Additionally,
we
explore
latest
areas
related
along
future
directions.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(7), P. 1086 - 1086
Published: April 7, 2024
Resveratrol
(RES)
has
been
reported
to
prevent
hyperuricemia
(HUA);
however,
its
effect
on
intestinal
uric
acid
metabolism
remains
unclear.
This
study
evaluated
the
impact
of
RES
in
mice
with
HUA
induced
by
a
high-fat
diet
(HFD).
Moreover,
we
revealed
underlying
mechanism
through
metagenomics,
fecal
microbiota
transplantation
(FMT),
and
16S
ribosomal
RNA
analysis.
We
demonstrated
that
reduced
serum
acid,
creatinine,
urea
nitrogen,
urinary
protein
levels,
improved
glomerular
atrophy,
unclear
renal
tubule
structure,
fibrosis,
inflammation.
The
results
also
showed
increased
degradation.
significantly
changed
flora
composition
HFD-fed
enriching
beneficial
bacteria
degrade
reducing
harmful
promote
inflammation,
improving
microbial
function
via
upregulation
purine
metabolism.
FMT
further
is
essential
for
HUA,
Lactobacillus
may
play
key
role
this
process.
present
alleviates
HFD-induced
injury
regulating
gut
acid.
