Therapeutic Targeting of the Tumor Microenvironment

Cancer Discovery, Journal Year: 2021, Volume and Issue: 11(4), P. 933 - 959

Published: April 1, 2021

Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due critical roles of TME regulating progression and modulating response standard-of-care therapies. Here, we summarize current knowledge regarding most advanced TME-directed therapies, which either been clinically approved or are currently being evaluated trials, including immunotherapies, antiangiogenic drugs, treatments directed against cancer-associated fibroblasts extracellular matrix. We also discuss some challenges associated with future perspectives this evolving field. Significance: This review provides comprehensive analysis therapies targeting TME, combining discussion underlying basic biology clinical evaluation different therapeutic approaches, highlighting perspectives.

Language: Английский

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Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(5), P. 298 - 312

Published: March 9, 2021

Language: Английский

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Clinical and therapeutic relevance of cancer-associated fibroblasts

Nature Reviews Clinical Oncology, Journal Year: 2021, Volume and Issue: 18(12), P. 792 - 804

Published: Sept. 6, 2021

Language: Английский

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Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Seminars in Cancer Biology, Journal Year: 2021, Volume and Issue: 85, P. 69 - 94

Published: June 25, 2021

Language: Английский

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Annual Report to the Nation on the Status of Cancer, Part 1: National Cancer Statistics

JNCI Journal of the National Cancer Institute, Journal Year: 2021, Volume and Issue: 113(12), P. 1648 - 1669

Published: June 28, 2021

The American Cancer Society, Centers for Disease Control and Prevention, National Institute, North Association of Central Registries collaborate to provide annual updates on cancer incidence mortality trends by type, sex, age group, racial/ethnic group in the United States. In this report, we also examine stage-specific survival melanoma skin (melanoma).Incidence data all cancers from 2001 through 2017 cases diagnosed during 2001-2014 followed-up 2016 were obtained Prevention- Institute-funded population-based registry programs compiled Registries. Data deaths 2018 Center Health Statistics' Vital Statistics System. Trends age-standardized death rates 2-year relative estimated joinpoint analysis, expressed as average percent change (AAPC) most recent 5 years (2013-2017 2014-2018 mortality).Overall (per 100 000 population) ages 2013-2017 487.4 among males 422.4 females. During period, remained stable but slightly increased females (AAPC = 0.2%, 95% confidence interval [CI] 0.1% 0.2%). Overall 185.5 133.5 overall decreased both -2.2%, CI -2.5% -1.9%) -1.7%, -2.1% -1.4%); 11 19 common 14 20 females, each sex. 2014-2018, declines accelerated lung melanoma, slowed down colorectal female breast cancers, leveled off prostate cancer. Among children younger than 15 adolescents young adults aged 15-39 years, continued decrease contrast increasing rates. Two-year distant-stage was those 2001-2009 3.1% (95% 2.8% 3.5%) per year 2009-2014, with comparable females.Cancer States continue decline many types, melanoma. For several other major however, increase or previous have ceased. Moreover, children, adults. These findings inform efforts related prevention, early detection, treatment broad equitable implementation effective interventions, especially under resourced populations.

Language: Английский

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Metastasis

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

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Diffuse Glioma Heterogeneity and Its Therapeutic Implications

Cancer Discovery, Journal Year: 2021, Volume and Issue: 11(3), P. 575 - 590

Published: Feb. 8, 2021

Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies. Recent advances have revealed that remarkable level genetic, epigenetic, and environmental heterogeneity exists within each individual glioma. Together, these interconnected layers intratumoral result in extreme phenotypic at the cellular level, providing for multiple mechanisms therapeutic resistance forming highly adaptable resilient disease. In this review, we discuss how glioma malignant state plasticity drive to existing therapies look future which challenges may be overcome. SIGNIFICANCE: Glioma cell formidable hurdles development novel targeted However, convergence genotypically diverse cells into limited set epigenetically encoded transcriptional states present an opportunity strategy call "State Selective Lethality." approach, (as opposed genetic perturbations/mutations) are subject targeting, plasticity-mediated is minimized through design "trapping agents."

Language: Английский

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CD8+ T Cell Exhaustion in Cancer

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 20, 2021

A paradigm shift in the understanding of exhausted CD8 + T cell (T ex ) lineage is underway. Originally thought to be a uniform population that progressively loses effector function response persistent antigen, single-cell analysis has now revealed composed multiple interconnected subpopulations. The heterogeneity within comprised immune checkpoint blockade (ICB) permissive and refractory subsets termed stem-like terminally differentiated cells, respectively. These populations occupy distinct peripheral intratumoral niches are characterized by transcriptional processes govern transitions between states. This review presents key findings field construct an updated view spatial, transcriptional, functional anti-tumoral . emerging insights broadly call for (re-)focusing cancer immunotherapies center on driver mechanism(s) underlying developmental continuum aimed at stabilizing subsets.

Language: Английский

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The cGAS–STING pathway and cancer

Nature Cancer, Journal Year: 2022, Volume and Issue: 3(12), P. 1452 - 1463

Published: Dec. 12, 2022

Language: Английский

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Modes of Regulated Cell Death in Cancer

Cancer Discovery, Journal Year: 2021, Volume and Issue: 11(2), P. 245 - 265

Published: Jan. 18, 2021

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD modalities, namely apoptosis, entosis, necroptosis, pyroptosis, ferroptosis. We explore how various modules serve as defense mechanism against the emergence cancer well manner which they can be exploited to drive oncogenesis. Furthermore, outline current therapeutic agents that activate consider novel RCD-based strategies for tumor elimination. SIGNIFICANCE: A variety antitumor therapeutics eliminate cells by harnessing devastating potential cellular emphasizing importance battling cancer. This review supplies mechanistic perspective distinct modalities explores important tumorigenesis. discuss double-edged sword approaches aimed at selectively manipulating eradication.

Language: Английский

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