Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 23, 2025
Viral
infectious
diseases,
caused
by
numerous
viruses
including
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
influenza
A
virus
(IAV),
enterovirus
(EV),
human
immunodeficiency
(HIV),
hepatitis
B
(HBV),
and
papillomavirus
(HPV),
pose
a
continuous
threat
to
global
health.
As
obligate
parasites,
rely
on
host
cells
replicate,
have
developed
defense
mechanisms
counteract
viral
infection.
Host
restriction
factors
(HRFs)
are
critical
components
of
the
early
antiviral
response.
These
cellular
proteins
inhibit
replication
spread
impeding
essential
steps
in
life
cycle,
such
as
entry,
genome
transcription
replication,
protein
translation,
particle
assembly,
release.
This
review
summarizes
current
understanding
how
with
primary
focus
their
diverse
against
range
viruses,
SARS-CoV-2,
virus,
enteroviruses,
papillomavirus.
In
addition,
we
highlight
crucial
role
these
shaping
host-virus
interactions
discuss
potential
targets
for
drug
development.
iScience,
Journal Year:
2023,
Volume and Issue:
26(10), P. 107733 - 107733
Published: Aug. 24, 2023
Bacillus
Calmette-Guérin
(BCG)
confers
heterologous
immune
protection
against
viral
infections
and
has
been
proposed
as
vaccine
SARS-CoV-2
(SCV2).
Here,
we
tested
intravenous
BCG
vaccination
COVID-19
using
the
golden
Syrian
hamster
model.
conferred
a
modest
reduction
on
lung
SCV2
load,
bronchopneumonia
scores,
weight
loss,
accompanied
by
reversal
of
SCV2-mediated
T
cell
lymphopenia,
reduced
granulocytes.
uniquely
recruited
immunoglobulin-producing
plasma
cells
to
suggesting
accelerated
local
antibody
production.
also
elevated
levels
Th1,
Th17,
Treg,
CTLs,
Tmem
cells,
with
transcriptional
shift
away
from
exhaustion
markers
toward
antigen
presentation
repair.
Similarly,
enhanced
recruitment
alveolar
macrophages
key
interstitial
macrophage
subsets,
that
show
IFN-associated
gene
expression.
Our
observations
indicate
protects
immunopathology
promoting
early
immunoglobulin
production
immunotolerizing
patterns
among
myeloid
lymphoid
populations.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
277, P. 132755 - 132755
Published: May 29, 2024
Interferon-induced
transmembrane
3
(IFITM3)
is
a
membrane-associated
protein
that
exhibits
antiviral
activities
against
wide
range
of
viruses
through
interactions
with
other
cellular
and
viral
proteins.
However,
knowledge
the
mechanisms
IFITM3
in
Porcine
deltacoronavirus
(PDCoV)
infection
has
been
lacking.
In
this
study,
we
demonstrate
IFN-α
treatment
induces
upregulation
activity
thus
attenuates
PDCoV
infection.
replication
inhibited
dose-dependent
manner
by
overexpression.
To
clarify
novel
roles
during
infection,
proteins
interact
were
screened
TAP/MS
an
ST
cell
line
stably
expressing
via
lentivirus.
We
identified
known
candidate
IFITM3-binding
analyzed
complexes
using
GO
annotation,
KEGG
pathway
analysis,
interaction
network
analysis.
A
total
362
associate
first
24
h
post-infection.
Of
these
proteins,
relationship
between
Rab9a
was
evaluated
immunofluorescence
colocalization
analysis
confocal
microscopy.
partially
colocalized
exhibited
enhanced
following
also
demonstrated
interacts
specifically
Rab9a.
Our
results
considerably
expand
networks
IFITM3,
suggesting
participates
multiple
processes
Veterinary Research,
Journal Year:
2025,
Volume and Issue:
56(1)
Published: Jan. 9, 2025
Abstract
Swine
acute
diarrhoea
syndrome
coronavirus
(SADS-CoV),
a
novel
HKU2-related
of
bat
origin,
is
newly
emerged
swine
enteropathogenic
that
causes
severe
in
piglets.
SADS-CoV
has
broad
cell
tropism
with
the
capability
to
infect
wide
variety
cells
from
human
and
diverse
animals,
which
implicates
its
ability
hold
high
risks
cross-species
transmission.
The
intracellular
antiviral
immunity,
comprised
intrinsic
innate
represents
first
line
host
defence
against
viral
infection
prior
onset
adaptive
immunity.
To
date,
there
are
no
vaccines
drugs
approved
prevent
or
treat
infection.
Understanding
mutual
relationship
between
immunity
crucial
for
development
SADS-CoV.
Here,
we
review
recent
advancements
our
understanding
interplay
extensive
in-depth
investigation
on
their
interactive
will
contribute
identification
new
targets
developing
intervention
strategies
control
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 23, 2025
Viral
infectious
diseases,
caused
by
numerous
viruses
including
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
influenza
A
virus
(IAV),
enterovirus
(EV),
human
immunodeficiency
(HIV),
hepatitis
B
(HBV),
and
papillomavirus
(HPV),
pose
a
continuous
threat
to
global
health.
As
obligate
parasites,
rely
on
host
cells
replicate,
have
developed
defense
mechanisms
counteract
viral
infection.
Host
restriction
factors
(HRFs)
are
critical
components
of
the
early
antiviral
response.
These
cellular
proteins
inhibit
replication
spread
impeding
essential
steps
in
life
cycle,
such
as
entry,
genome
transcription
replication,
protein
translation,
particle
assembly,
release.
This
review
summarizes
current
understanding
how
with
primary
focus
their
diverse
against
range
viruses,
SARS-CoV-2,
virus,
enteroviruses,
papillomavirus.
In
addition,
we
highlight
crucial
role
these
shaping
host-virus
interactions
discuss
potential
targets
for
drug
development.
