Vaccines,
Journal Year:
2023,
Volume and Issue:
11(4), P. 875 - 875
Published: April 20, 2023
Immunological
memory
is
the
key
source
of
protective
immunity
against
pathogens.
At
current
stage
COVID-19
pandemic,
heterologous
combinations
exposure
to
viral
antigens
during
infection
and/or
vaccination
shape
a
distinctive
immunological
memory.
Immune
imprinting,
downside
memory,
might
limit
generation
de
novo
immune
response
variant
or
next-generation
vaccines.
Here,
we
review
mechanistic
basis
imprinting
by
focusing
on
B
cell
immunobiology
and
discuss
extent
which
harmful,
as
well
its
effect
SARS-CoV-2
vaccination.
Immunological Reviews,
Journal Year:
2022,
Volume and Issue:
310(1), P. 27 - 46
Published: June 22, 2022
Immunological
memory
is
the
basis
of
protective
immunity
provided
by
vaccines
and
previous
infections.
can
develop
from
multiple
branches
adaptive
immune
system,
including
CD4
T
cells,
CD8
B
long-lasting
antibody
responses.
Extraordinary
progress
has
been
made
in
understanding
to
SARS-CoV-2
infection
COVID-19
vaccines,
addressing
development;
quantitative
qualitative
features
different
cellular
anatomical
compartments;
durability
each
component
antibodies.
Given
sophistication
measurements;
size
human
studies;
use
longitudinal
samples
cross-sectional
head-to-head
comparisons
between
or
for
1
year
already
supersedes
that
any
other
acute
infectious
disease.
This
knowledge
may
help
inform
public
policies
regarding
as
well
scientific
development
future
against
diseases.
Science,
Journal Year:
2023,
Volume and Issue:
382(6675)
Published: Dec. 7, 2023
The
spatial
distribution
of
lymphocyte
clones
within
tissues
is
critical
to
their
development,
selection,
and
expansion.
We
have
developed
transcriptomics
variable,
diversity,
joining
(VDJ)
sequences
(Spatial
VDJ),
a
method
that
maps
B
cell
T
receptor
in
human
tissue
sections.
Spatial
VDJ
captures
match
canonical
distributions
amplifies
clonal
confirmed
by
orthogonal
methods.
found
congruency
between
paired
chains,
computational
framework
predict
pairs,
linked
the
expansion
distinct
different
tumor-associated
gene
expression
programs.
delineates
diversity
lineage
trajectories
anatomical
niche.
Thus,
architecture
across
tissues,
providing
platform
harness
for
therapy.
