DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications DOI Open Access
Bingyu Lin, Yanfei Liu, Qi‐Wen Chen

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Current tumor vaccines suffer from inadequate immune responsive due to the insufficient release of antigens, low infiltration, and immunosuppressive microenvironment. DNA nanostructures with their ability precisely engineer, controlled release, biocompatibility, capability augment immunogenicity microenvironment, have gained significant attention for potential revolutionize vaccine designing. This review summarizes various applications in construction situ cancer vaccines, which can generate tumor‐associated antigens directly damaged tumors immune‐stimulation. The mechanisms components are listed, specific strategies constructing using explored underlying action elucidated. immunogenic cell death (ICD) induced by chemotherapeutic agents, photothermal therapy (PTT), photodynamic (PDT), radiation (RT) related building systematically summarized. different immunotherapy elaborated, exerts precise, long‐lasting, robust responses. current challenges future prospectives proposed. provides a holistic understanding evolving role development.

Language: Английский

Principles and therapeutic applications of adaptive immunity DOI Creative Commons
Hongbo Chi, Marion Pepper, Paul G. Thomas

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(9), P. 2052 - 2078

Published: April 1, 2024

Adaptive immunity provides protection against infectious and malignant diseases. These effects are mediated by lymphocytes that sense respond with targeted precision to perturbations induced pathogens tissue damage. Here, we review key principles underlying adaptive orchestrated distinct T cell B populations their extensions disease therapies. We discuss the intracellular intercellular processes shaping antigen specificity recognition in immune activation lymphocyte functions mediating effector memory responses. also describe how balance protective autoimmunity immunopathology, including during tolerance, response chronic stimulation, adaptation non-lymphoid tissues coordinating homeostasis. Finally, extracellular signals cell-intrinsic programs underpinning conclude summarizing advances vaccination engineering responses for therapeutic interventions. A deeper understanding of these holds promise uncovering new means improve human health.

Language: Английский

Citations

64
Immune imprinting and next-generation coronavirus vaccines DOI
Chloe Qingzhou Huang, Sneha Vishwanath, George Carnell

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(11), P. 1971 - 1985

Published: Nov. 6, 2023

Language: Английский

Citations

44
Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history DOI Creative Commons

Petra Kiszel,

Pál Sík,

János Miklós

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Aug. 13, 2023

Vaccinations against SARS-CoV-2 reduce the risk of developing serious COVID-19 disease. Monitoring spike-specific IgG subclass levels after vaccinations may provide additional information on specific humoral immune response. Here, we examined presence and antibody subclasses in health-care coworkers vaccinated with vector- (Sputnik, AstraZeneca) or mRNA-based (Pfizer-BioNTech, Moderna) vaccines unvaccinated patients. We found that vector-based elicited lower total than mRNA vaccines. The pattern individuals infected before resembled vector-vaccinated subjects However, mRNA-vaccinated without preinfection showed a markedly different pattern. In addition to IgG1 IgG3 presented all groups, switch towards distal (spike-specific IgG4 IgG2) appeared almost exclusively who received only were vaccinations. these subjects, magnitude response was comparable These data suggest priming system either by natural infection has an important impact characteristics developed immunity.

Language: Английский

Citations

42
A guide to adaptive immune memory DOI
Nora Lam, Yoon Seung Lee, Donna L. Färber

et al.

Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: June 3, 2024

Language: Английский

Citations

35
B cell memory: from generation to reactivation: a multipronged defense wall against pathogens DOI Creative Commons
Madiha Zahra Syeda,

Hong Tu,

Chun‐Ming Huang

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: March 7, 2024

Development of B cell memory is a conundrum that scientists are still exploring. Studies have been conducted in vitro and using advanced animal models to elucidate the mechanism underlying generation cells (MBCs), precise roles MBCs against pathogens, their protective functions repeated infections throughout life. Lifelong immunity invading diseases mainly result overcoming single infection. This protection largely mediated by two main components memory-MBCs long-lived plasma (PCs). The chemical cellular mechanisms encourage fat selection for or PCs an area active research. Despite fact nearly all available vaccinations rely on capacity elicit B-cell memory, we yet develop successful vaccines can induce broad-scale some deadliest diseases, including malaria AIDS. A deeper understanding specific molecular pathways govern generation, function, reactivation critical challenges associated with vaccine development. Here, reviewed literature development reactivation, interaction other types, strategies function life discussed recent advances regarding key signals transcription factors which regulate relevance quest

Language: Английский

Citations

18
Opposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers DOI
Ariën Schiepers,

Marije F.L. van’t Wout,

Alvaro Hobbs

et al.

Immunity, Journal Year: 2024, Volume and Issue: 57(7), P. 1618 - 1628.e4

Published: June 5, 2024

Language: Английский

Citations

18
The interaction of innate immune and adaptive immune system DOI Creative Commons

Ruyuan Wang,

Caini Lan, Kamel Benlagha

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(10)

Published: Sept. 15, 2024

The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll-like to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific sustained killing via B cells, T antibodies. Traditionally, it has been assumed that activates immunity; however, recent studies have revealed more complex interactions. This review a detailed dissection composition function systems, emphasizing their synergistic roles in physiological pathological contexts, providing new insights into link between these two forms immunity. Precise regulation both systems at same time is beneficial fight against immune-related diseases, for example, cGAS-STING pathway found play an important role infections cancers. In addition, paper summarizes challenges future directions field immunity, including latest single-cell sequencing technologies, CAR-T cell therapy, checkpoint inhibitors. By summarizing developments, aims enhance our understanding complexity interactions perspectives system.

Language: Английский

Citations

18
Lupus nephritis-related chronic kidney disease DOI
Julia Lichtnekert, Hans‐Joachim Anders

Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(11), P. 699 - 711

Published: Sept. 24, 2024

Language: Английский

Citations

12
Components, Formulations, Deliveries, and Combinations of Tumor Vaccines DOI
Tengfei Liu,

Wenyan Yao,

Wenyu Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(29), P. 18801 - 18833

Published: July 9, 2024

Tumor vaccines, an important part of immunotherapy, prevent cancer or kill existing tumor cells by activating restoring the body's own immune system. Currently, various formulations vaccines have been developed, including cell membrane DNA mRNA polypeptide virus-vectored and tumor-in-situ vaccines. There are also multiple delivery systems for such as liposomes, vesicles, viruses, exosomes, emulsions. In addition, to decrease risk escape tolerance that may exist with a single vaccine, combination therapy radiotherapy, chemotherapy, checkpoint inhibitors, cytokines, CAR-T therapy, photoimmunotherapy is effective strategy. Given critical role in here, we look back history discuss antigens, adjuvants, formulations, systems, mechanisms, future directions

Language: Английский

Citations

10
The Role of Dendritic Cells in Adaptive Immune Response Induced by OVA/PDDA Nanoparticles DOI Creative Commons

Daniele Rodrigues Pereira,

Yunys Pérez-Betancourt, Bianca de Carvalho Lins Fernandes Távora

et al.

Vaccines, Journal Year: 2025, Volume and Issue: 13(1), P. 76 - 76

Published: Jan. 16, 2025

Background/Objective: Cationic polymers were shown to assemble with negatively charged proteins yielding nanoparticles (NPs). Poly-diallyl-dimethyl-ammonium chloride (PDDA) combined ovalbumin (OVA) yielded a stable colloidal dispersion (OVA/PDDA-NPs) eliciting significant anti-OVA immune response. Dendritic cells (DCs), as sentinels of foreign antigens, exert crucial role in the antigen-specific Here, we aimed evaluate involvement DCs response induced by OVA/PDDA. Methods: In vivo experiments used assess ability OVA/PDDA-NPs induce antibodies ELISA, well plasma and memory B using flow cytometry. Additionally, DC migration draining lymph nodes following OVA/PDDA-NP immunization was evaluated vitro bone marrow-derived (BM-DCs) analyze binding uptake OVA/PDDA-NPs, maturation status, their antigen-presenting capacity. Results: Our data confirmed potent effect inducing IgG1 IgG2a increased CD19+CD138+ CD19+CD38+CD27+ immunized mice. nodes. The results showed higher BM-DCs. addition, NPs able upregulation costimulatory MHC-II molecules on DCs, TNF-α IL-12 production. Higher OVA-specific T cell proliferation promoted BM-DCs incubated OVA/PDDA-NPs. Conclusions: central induction OVA-PDDA-NPs, thus proving that these are adjuvant for subunit vaccine design.

Language: Английский

Citations

1