Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3273 - 3301
Published: Jan. 1, 2024
Oral
diseases
are
prevalent
but
challenging
owing
to
the
highly
movable
and
wet,
microbial
inflammatory
environment.
Polymeric
materials
regarded
as
one
of
most
promising
biomaterials
due
their
good
compatibility,
facile
preparation,
flexible
design
obtain
multifunctionality.
Therefore,
a
variety
strategies
have
been
employed
develop
with
improved
therapeutic
efficacy
by
overcoming
physicobiological
barriers
in
oral
diseases.
In
this
review,
we
summarize
polymeric
for
treatment
First,
present
unique
environment
including
environment,
which
hinders
effective
Second,
series
designing
towards
such
highlighted.
For
example,
multifunctional
armed
wet-adhesive,
antimicrobial,
anti-inflammatory
functions
through
advanced
chemistry
nanotechnology
effectively
treat
These
achieved
wet-adhesive
polymers
modified
hydroxy,
amine,
quinone,
aldehyde
groups
provide
strong
wet-adhesion
hydrogen
covalent
bonding,
electrostatic
hydrophobic
interactions,
developing
antimicrobial
cationic
polymers,
peptides,
antibiotic-conjugated
synthesizing
phenolic
hydroxy
cysteine
that
function
immunomodulators
electron
donors
reactive
oxygen
species
reduce
inflammation.
Third,
various
delivery
systems
enhanced
mucosa
biofilm
penetration
capabilities,
nanoparticles,
hydrogels,
patches,
microneedles,
constructed
antibiotics,
immunomodulators,
antioxidants
achieve
efficacy.
Finally,
insights
into
challenges
future
development
promise
clinical
translation.
Molecular Cancer,
Journal Year:
2023,
Volume and Issue:
22(1)
Published: Oct. 9, 2023
Abstract
The
use
of
nanotechnology
has
the
potential
to
revolutionize
detection
and
treatment
cancer.
Developments
in
protein
engineering
materials
science
have
led
emergence
new
nanoscale
targeting
techniques,
which
offer
renewed
hope
for
cancer
patients.
While
several
nanocarriers
medicinal
purposes
been
approved
human
trials,
only
a
few
authorized
clinical
cells.
In
this
review,
we
analyze
some
formulations
discuss
challenges
translating
findings
from
lab
clinic.
This
study
highlights
various
compounds
that
can
be
used
selective
tumor
inherent
difficulties
therapy.
Nanotechnology
provides
promising
platform
improving
future,
but
further
research
is
needed
overcome
current
limitations
translation.
Graphical
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(51)
Published: May 17, 2023
Abstract
Messenger
RNA
(mRNA)
has
received
great
attention
in
the
prevention
and
treatment
of
various
diseases
due
to
success
coronavirus
disease
2019
(COVID‐19)
mRNA
vaccines
(Comirnaty
Spikevax).
To
meet
therapeutic
purpose,
it
is
required
that
must
enter
target
cells
express
sufficient
proteins.
Therefore,
development
effective
delivery
systems
necessary
crucial.
Lipid
nanoparticle
(LNP)
represents
a
remarkable
vehicle
indeed
accelerated
applications
humans,
as
several
mRNA‐based
therapies
have
already
been
approved
or
are
clinical
trials.
In
this
review,
focus
on
mRNA‐LNP‐mediated
anticancer
therapy.
It
summarizes
main
strategies
mRNA‐LNP
formulations,
discusses
representative
approaches
cancer,
points
out
current
challenges
possible
future
directions
research
field.
hoped
these
delivered
messages
can
help
further
improve
application
technology
cancer
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 976 - 976
Published: March 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Oct. 4, 2023
Abstract
Lipid‐based
nanoparticles
(LBNPs)
are
currently
the
most
promising
vehicles
for
nucleic
acid
drug
(NAD)
delivery.
Although
their
clinical
applications
have
achieved
success,
NAD
delivery
efficiency
and
safety
still
unsatisfactory,
which
are,
to
a
large
extent,
due
existence
of
multi‐level
physiological
barriers
in
vivo.
It
is
important
elucidate
interactions
between
these
LBNPs,
will
guide
more
rational
design
efficient
with
low
adverse
effects
facilitate
broader
therapeutics.
This
review
describes
obstacles
challenges
biological
at
systemic,
organ,
sub‐organ,
cellular,
subcellular
levels.
The
strategies
overcome
comprehensively
reviewed,
mainly
including
physically/chemically
engineering
LBNPs
directly
modifying
by
auxiliary
treatments.
Then
potentials
successful
translation
preclinical
studies
into
clinic
discussed.
In
end,
forward
look
on
manipulating
protein
corona
(PC)
addressed,
may
pull
off
trick
overcoming
those
significantly
improve
efficacy
LBNP‐based
NADs
