Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

EBioMedicine, Journal Year: 2021, Volume and Issue: 66, P. 103293 - 103293

Published: April 1, 2021

The gut microbiome and the intestinal immune system are driving contributors to inflammatory bowel diseases (IBD). Both have an important signalling factor in common: short-chain fatty acids (SCFAs). SCFAs (acetate, propionate butyrate) produced by bacterial fermentation exert several effects on host metabolism system. This review provides overview of current knowledge these effects, with specific focus energy metabolism, barrier, system, disease activity IBD. To conclude, more research is needed cross-feeding mechanisms microbiome, as well therapeutic potential different models. Also randomized controlled trials prospective cohort studies should investigate clinical impact SCFA administration.

Language: Английский

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Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further

Frontiers in Nutrition, Journal Year: 2021, Volume and Issue: 8

Published: June 28, 2021

The genome of gut microbes encodes a collection enzymes whose metabolic functions contribute to the bioavailability and bioactivity unabsorbed (poly)phenols. Datasets from high throughput sequencing, metabolome measurements, other omics have expanded understanding different modes actions by which (poly)phenols modulate microbiome conferring health benefits host. Progress been made identify direct prebiotic effects (poly)phenols; albeit up date, these compounds are not recognized as prebiotics sensu stricto . Interestingly, certain probiotics strains an enzymatic repertoire, such tannase, α-L-rhamnosidase, phenolic acid reductase, involved in transformation into bioactive metabolites. In vivo studies demonstrated that (poly)phenol-transforming bacteria thrive when provided with substrates. However, taxonomically distinct symbionts phenolic-metabolizing activity has still significantly promoted This is case Akkermansia muciniphila , so-called antiobesity bacterium, responds positively may be partially responsible for formerly attributed molecules. We surmise broad antimicrobial action free ecological niches occupied competing bacteria, thereby allowing bloom beneficial bacteria. review explores capacity promote through their collaborative bacterial utilization inhibitory on potential pathogenic species. propose term duplibiotic describe substrate modulating microbiota both action. (Poly)phenol effect could participate blunting disturbance dysbiosis, positioning dietary strategies therapeutic potential.

Language: Английский

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Multi-kingdom ecological drivers of microbiota assembly in preterm infants

Nature, Journal Year: 2021, Volume and Issue: 591(7851), P. 633 - 638

Published: Feb. 24, 2021

Language: Английский

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Bacteria-driven phthalic acid ester biodegradation: Current status and emerging opportunities

Environment International, Journal Year: 2021, Volume and Issue: 154, P. 106560 - 106560

Published: April 16, 2021

The extensive use of phthalic acid esters (PAEs) has led to their widespread distribution across various environments. As PAEs pose significant threats human health, it is urgent develop efficient strategies eliminate them from Bacteria-driven PAE biodegradation been considered as an inexpensive yet effective strategy restore the contaminated Despite great advances in bacterial culturing and sequencing, inherent complexity indigenous microbial community hinders us mechanistically understand situ efficiently harness degrading power bacteria. synthetic ecology provides a simple controllable model system address this problem. In review, we focus on current progress mediated by isolates communities, discuss prospective PAE-degrading communities research. It anticipated that theories approaches will revolutionize study bacteria-driven provide novel insights for developing bioremediation solutions.

Language: Английский

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The Role of the Gut Microbiota in the Pathogenesis of Diabetes

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(1), P. 480 - 480

Published: Jan. 1, 2022

Diabetes mellitus is a significant clinical and therapeutic problem because it can lead to serious long-term complications. Its pathogenesis not fully understood, but there are indications that dysbiosis play role in the development of diabetes, or appears during course disease. Changes microbiota composition observed both type 1 diabetes (T1D) 2 (T2D) patients. These modifications associated with pro-inflammation, increased intestinal permeability, endotoxemia, impaired β-cell function insulin resistance. This review summarizes gut healthy individuals changes bacterial be T1D T2D. It also presents new developments therapy based on influencing as promising method alter diabetes. Moreover, highlights lacking data suggests future directions needed prove causal relationship between

Language: Английский

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Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(10), P. 1717 - 1763

Published: May 8, 2023

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.

Language: Английский

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Single-cell approaches in human microbiome research

Cell, Journal Year: 2022, Volume and Issue: 185(15), P. 2725 - 2738

Published: July 1, 2022

Language: Английский

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Alternative stable states, nonlinear behavior, and predictability of microbiome dynamics

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: March 29, 2023

Abstract Background Microbiome dynamics are both crucial indicators and potential drivers of human health, agricultural output, industrial bio-applications. However, predicting microbiome is notoriously difficult because communities often show abrupt structural changes, such as “dysbiosis” in microbiomes. Methods We integrated theoretical frameworks empirical analyses with the aim anticipating drastic shifts microbial communities. monitored 48 experimental microbiomes for 110 days observed that various community-level events, including collapse gradual compositional occurred according to a defined set environmental conditions. analyzed time-series data based on statistical physics non-linear mechanics describe characteristics examine predictability major community structure. Results confirmed changes through could be described between “alternative stable states“ or around complex attractors. Furthermore, collapses structure were successfully anticipated by means diagnostic threshold “energy landscape” analysis stability index nonlinear mechanics. Conclusions The results indicate events can forecasted extending classic ecological concepts scale species-rich systems.

Language: Английский

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Exploring the controllability of the Baijiu fermentation process with microbiota orientation

Food Research International, Journal Year: 2023, Volume and Issue: 173, P. 113249 - 113249

Published: July 19, 2023

Language: Английский

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Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

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