Symbioses between fungi and bacteria: from mechanisms to impacts on biodiversity DOI Creative Commons
Teresa E. Pawlowska

Current Opinion in Microbiology, Journal Year: 2024, Volume and Issue: 80, P. 102496 - 102496

Published: June 13, 2024

Symbiotic interactions between fungi and bacteria range from positive to negative. They are ubiquitous in free-living as well host-associated microbial communities worldwide. Yet, the impact of fungal-bacterial symbioses on organization dynamics is uncertain. There two reasons for this uncertainty: (1) knowledge gaps understanding genetic mechanisms underpinning (2) prevailing interpretations ecological theory that favor antagonistic drivers stabilizing biological despite existence models emphasizing contributions interactions. This review synthesizes information common soil polymicrobial biofilms. The interdomain partnerships considered context relevant community ecology models, which discussed critically.

Language: Английский

The ecological roles of bacterial chemotaxis DOI
Johannes M. Keegstra, Francesco Carrara, Roman Stocker

et al.

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(8), P. 491 - 504

Published: March 15, 2022

Language: Английский

Citations

188
Bacterial defences: mechanisms, evolution and antimicrobial resistance DOI
William P. J. Smith, Benjamin R. Wucher, Carey D. Nadell

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(8), P. 519 - 534

Published: April 24, 2023

Language: Английский

Citations

167
Bacterial genome size and gene functional diversity negatively correlate with taxonomic diversity along a pH gradient DOI Creative Commons
Cong Wang, Qingyi Yu, Niu‐Niu Ji

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 17, 2023

Abstract Bacterial gene repertoires reflect adaptive strategies, contribute to ecosystem functioning and are limited by genome size. However, functional diversity does not necessarily correlate with taxonomic because average size may vary community. Here, we analyse (by shotgun metagenomics) 16S rRNA amplicon sequencing) investigate soil bacterial communities along a natural pH gradient in 12 tropical, subtropical, temperate forests. We find that decrease, whereas increases, as rises from acid neutral; result, negatively correlated. The repertoire of acid-adapted oligotrophs is enriched functions signal transduction, cell motility, secretion system, degradation complex compounds, while neutral pH-adapted copiotrophs energy metabolism membrane transport. Our results indicate mismatch between can arise when environmental factors (such pH) select for strategies affect distributions.

Language: Английский

Citations

52
Animating hydrogel knotbots with topology-invoked self-regulation DOI Creative Commons
Qing Zhu, Weixuan Liu,

Olena Khoruzhenko

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Jan. 5, 2024

Abstract Steering soft robots in a self-regulated manner remains grand challenge, which often requires continuous symmetry breaking and recovery steps for persistent motion. Although structural morphology is found significant robotic functions, geometric topology has rarely been considered appreciated. Here we demonstrate series of knotbots, namely hydrogel-based with knotted structures, capable autonomous rolling spinning/rotating motions. With broken by external stimuli restored self-regulation, the coupling between self-constraint-induced prestress photothermal strain animates knotbots continuously. Experiments simulations reveal that nonequilibrium processes are regulated dynamically cooperatively self-constraints, active deformations, self-shadowing effect photo-responsive gel. The motions enable to execute tasks including gear rotation rod climbing. This work paves way devise advanced sustainable harnessing topology.

Language: Английский

Citations

35
Shaping of microbial phenotypes by trade-offs DOI Creative Commons
Manlu Zhu, Xiongfeng Dai

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 18, 2024

Abstract Growth rate maximization is an important fitness strategy for microbes. However, the wide distribution of slow-growing oligotrophic microbes in ecosystems suggests that rapid growth often not favored across ecological environments. In many circumstances, there exist trade-offs between and other traits (e.g., adaptability survival) due to physiological proteome constraints. Investments on alternative could compromise need adopt bet-hedging strategies improve fluctuating Here we review mechanistic role controlling bacterial further highlight its implications driving emergences phenomena such as co-existence, population heterogeneity oligotrophic/copiotrophic lifestyles.

Language: Английский

Citations

17
Innovative Applications of Bacteria and Their Derivatives in Targeted Tumor Therapy DOI

Denghui Zhu,

Wei Pan,

Heqi Li

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Despite significant progress in cancer treatment, traditional therapies still face considerable challenges, including poor targeting, severe toxic side effects, and the development of resistance. Recent advances biotechnology have revealed potential bacteria their derivatives as drug delivery systems for tumor therapy by leveraging biological properties. Engineered bacteria, Escherichia coli, Salmonella, Listeria monocytogenes, along with derivatives─outer membrane vesicles (OMVs), bacterial ghosts (BGs), spores (BSPs)─can be loaded a variety antitumor agents, enabling precise targeting sustained release within microenvironment (TME). These possess intrinsic properties that stimulate immune system, enhancing both innate adaptive responses to further amplify therapeutic effects. The ability naturally accumulate hypoxic regions versatility genetic modifications allow tailored strategies synergistically enhance effectiveness chemotherapy, immunotherapy, targeted therapies. This review comprehensively examines fundamental principles therapy, focusing on employed engineering, loading, use therapy. It also discusses challenges faced optimizing systems, such safety concerns, unintended responses, scalability clinical applications. By exploring these aspects, this provides theoretical framework improving bacterial-based contributing more effective personalized treatments.

Language: Английский

Citations

3
Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits DOI Creative Commons
Zishu Liu,

Xiangwu Yao,

Cheng‐Yi Chen

et al.

Microbiome, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 13, 2025

The widespread selective pressure of antibiotics in the environment has led to propagation antibiotic resistance genes (ARGs). However, mechanisms by which microbes balance population growth with enrichment ARGs remain poorly understood. To address this, we employed microcosm cultivation at different (i.e., Oxytetracycline, OTC) stresses across concentrations from environmental clinical. Paired shot-gun metagenomics analysis and quantification bacterial growth, trait-based assessment soil microbiota was applied reveal association between key ARG subtypes, representative taxa, functional-gene features that drive ARGs. Our results illuminate resistome variation is closely associated growth. A non-monotonic change abundance richness observed over a concentration gradient none 10 mg/l. Soil exposed intermediate OTC 0.1 0.5 mg/l) showed greater increases total Community compositionally, i.e., Pseudomonadaceae considered boost increase It chromosomally carried kinds multidrug such as mexAB-oprM mexCD-oprJ could mediate intrinsic OTC. Streptomycetaceae shown better adaptive ability than other clinical concentrations. it contributed less represents stress-tolerant lifestyle grows slowly carries fewer In terms community genetic features, aggregated traits further indicates enhancement resource acquisition yield driving abundance. Moreover, optimizations energy production conversion, alongside streamlining bypass metabolic pathways, sub-inhibitory conditions. this study suggest competitive lifestyles are selected under stress nutrient scarcity. They possess substrate utilization capacity carry more ARGs, due they were faster growing leading This expanded application assessments understanding ecology propagation. And finding illustrated changes accompanied switching microbiome, theoretically supports control approach based on principle species exclusion.

Language: Английский

Citations

2
An atlas of metabolites driving chemotaxis in prokaryotes DOI Creative Commons
Maéva Brunet, Shady A. Amin, Iurii Bodachivskyi

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 1, 2025

Language: Английский

Citations

2
Physical communication pathways in bacteria: an extra layer to quorum sensing DOI Creative Commons

Virgilio de la Viuda,

Javier Buceta, Iago Grobas

et al.

Biophysical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

2
Tissue-like multicellular development triggered by mechanical compression in archaea DOI
Theopi Rados, Olivia S. Leland, Pedro Escudeiro

et al.

Science, Journal Year: 2025, Volume and Issue: 388(6742), P. 109 - 115

Published: April 4, 2025

The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely bacteria, and only once archaea. We show that uniaxial compression induces haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal undergo multinucleate stage followed by tubulin-independent cellularization, orchestrated active membrane tension at cell size. After tissue junction elasticity becomes akin to animal tissues, giving rise two types—peripheral (Per) central scutoid (Scu) cells—with actin protein glycosylation polarity patterns. Our findings highlight the potential convergent evolution biophysical mechanism emergence multicellular systems across domains life.

Language: Английский

Citations

2