Microbial dark matter and the future of dentistry DOI Creative Commons
Jill Sirko, Batbileg Bor, Xuesong He

et al.

JADA Foundational Science, Journal Year: 2025, Volume and Issue: 4, P. 100043 - 100043

Published: Jan. 1, 2025

We are pleased to introduce a new series, "Innovations of Excellence, powered by ADA Forsyth," which provides forum for brief introductions technologies, therapeutic approaches, and health care trends interest oral clinicians researchers-a "window" into the latest scientific discoveries.Inspired

Language: Английский

The oral–gut microbiome axis in health and disease DOI
Benoît J. Kunath, Charlotte De Rudder, Cédric C. Laczny

et al.

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(12), P. 791 - 805

Published: July 22, 2024

Language: Английский

Citations

30
Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment DOI Creative Commons
Bo Jia, Beibei Zhang, J. Li

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

Citations

16
The dynamic oral–gastric microbial axis connects oral and gastric health: current evidence and disputes DOI Creative Commons
Mengying Xia, Lei Lei, Lin-Yong Zhao

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 2, 2025

Emerging evidence indicates that oral microbes are closely related to gastric and lesions, including atrophy, intestinal metaplasia cancer (GC). Helicobacter pylori is a key pathogen involved in GC. However, the increasing prevalence of H. pylori-negative GC dysbiosis patients emphasize potential role other microbial factors. In this review, we discussed current about relationship between oral–gastric axis health. Epidemiologic poor hygiene greater risk. Multiple oral-associated enriched stomach patients. Once colonizing stomach, Streptococcus anginosus Prevotella melaninogenica, inflammation or carcinogenesis. Microbial metabolites such as lactate, nitrite, acetaldehyde promote malignant transformation. The checkpoint transmission digestive tract, great importance since link diseases has been emphasized. Still, new technologies standardized metrics necessary identify pathogenetic for core microbiota, interactions, richness, colonization, location effect (CIRCLE). future, could be candidates noninvasive indicators predict diseases.

Language: Английский

Citations

3
The oral-gut microbiota axis: a link in cardiometabolic diseases DOI Creative Commons
Qian Xu, Wenting Wang, Yiwen Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

Citations

2
Gut–X axis DOI Creative Commons
Lin Xu, Yu Zhang, Xueyan Li

et al.

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Citations

2
Episymbiotic Saccharibacteria TM7x modulates the susceptibility of its host bacteria to phage infection and promotes their coexistence DOI Creative Commons

Qiu Zhong,

Binyou Liao, Jiazhen Liu

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(16)

Published: April 9, 2024

Bacteriophages (phages) play critical roles in modulating microbial ecology. Within the human microbiome, factors influencing long-term coexistence of phages and bacteria remain poorly investigated. Saccharibacteria (formerly TM7) are ubiquitous members oral microbiome. These ultrasmall form episymbiotic relationships with their host impact physiology. Here, we showed that during surface-associated growth, a isolate (named TM7x) protects its bacterium, Schaalia odontolytica strain XH001) against lytic phage LC001 predation. RNA-Sequencing analysis identified XH001 gene cluster predicted functions involved biogenesis cell wall polysaccharides (CWP), whose expression is significantly down-regulated when forming symbiosis TM7x. Through genetic work, experimentally demonstrated this CWP on bacterial–phage interaction by affecting binding. In vitro coevolution experiments further heterogeneous populations TM7x-associated TM7x-free XH001, which display differential susceptibility to predation, promote coexistence. Our study highlights tripartite between episymbiont, phage. More importantly, present mechanism, i.e., episymbiont-mediated modulation bacteria, impacts predation contributes formation “source-sink” dynamics biofilm, promoting within

Language: Английский

Citations

13
Relationship between vaginal and oral microbiome in patients of human papillomavirus (HPV) infection and cervical cancer DOI Creative Commons
Wei Zhang,

Yanfei Yin,

Yisha Jiang

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 29, 2024

Abstract Background The aim of this study was to assess the microbial variations and biomarkers in vaginal oral environments patients with human papillomavirus (HPV) cervical cancer (CC) develop novel prediction models. Materials methods This included 164 samples collected from both tract subgingival plaque 82 women. participants were divided into four distinct groups based on their samples: control group (Z/KZ, n = 22), abortion (AB/KAB, 17), HPV-infected (HP/KHP, 21), (CC/KCC, 22). Microbiota analysis conducted using full-length 16S rDNA gene sequencing PacBio platform. Results bacterial community Z AB exhibited a relatively simple structure predominantly dominated by Lactobacillus. However, CC shows high abundances anaerobic bacteria alpha diversity. Biomarkers such as Bacteroides, Mycoplasma, Bacillus, Dialister , Porphyromonas Anaerococcus Prevotella identified indicators CC. Correlations established between elevated blood C-reactive protein (CRP) levels local/systemic inflammation, pregnancy, childbirth, abortion, which contribute unevenness microenvironment. altered diversity confirmed amino acid metabolism. Oral an inverse pattern that microbiome, indicating unique relationship. KCC significantly lower than KZ group, link health development. Several microbes, including Fusobacterium Campylobacter Capnocytophaga Veillonella Streptococcus Lachnoanaerobaculum Propionibacterium Lactobacillus Neisseria, biomarkers. Moreover, periodontal pathogens associated CRP hygiene conditions. Elevated metabolism closely linked presence pathogens. Positive correlations indicated synergistic relationship bacteria. Conclusion HPV infection impact microenvironments, affecting systemic synergy suggests use flora markers is potential screening tool for diagnosis

Language: Английский

Citations

9
Understanding Microbial Mediation of the Brain-Gut Axis DOI

J. Horn,

Desiree R. Delgadillo,

Emeran A. Mayer

et al.

Gastroenterology Clinics of North America, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

1
Bacterial transfer during sexual intercourse as a tool for forensic detection DOI Creative Commons
Ruby Dixon, Siobhon Egan, Matthew S. Payne

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111861 - 111861

Published: Feb. 1, 2025

In forensic science, detecting transfers of physical and biological material is critical for establishing evidence criminal involvement. Unique bacterial signatures from the reproductive system transfer during unprotected penetrative intercourse offer a novel tool investigation. Here, we demonstrate this using full-length 16S rRNA gene sequencing discuss impact barrier contraceptives. These microbial can potentially aid in sexual assault casework perpetrator identification when human male DNA absent.

Language: Английский

Citations

1
Disentangling the feedback loops driving spatial patterning in microbial communities DOI Creative Commons

A. D. Henderson,

Alessia Del Panta,

Olga T. Schubert

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 20, 2025

Language: Английский

Citations

1