Assessing Insect Growth Regulator Resistance Using Bioassays: A Systematic Review and Meta-Analysis of Methoprene and Pyriproxyfen Inhibition of Emergence in Three Vector Mosquito Species DOI Creative Commons

Mark Clifton,

Kristina Lopez

Tropical Medicine and Infectious Disease, Journal Year: 2025, Volume and Issue: 10(4), P. 87 - 87

Published: March 28, 2025

This systematic review and meta-analysis aims to: (1) characterize the distribution of published inhibition emergence (IE50, IE90, IE95) reference values for pyriproxyfen methoprene in Culex pipiens [L.], Aedes aegypti albopictus [Skuse]; (2) generate combined-effect IE using a DerSimonian Laird (DL) random-effects model to establish benchmarks future resistance assessments; (3) compare these with previously literature. A search was conducted PubMed, SciELO, J-STAGE, Google Scholar up 10 February 2025, following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. Eligible studies were primary, peer-reviewed literature that aligned World Health Organization (WHO) protocols insect growth regulator (IGR) testing, specifically those reporting susceptible from continuous immersion dose-response bioassays analyzed probit regression. total 72 unique WHO assessed publication bias funnel plot Egger's Sensitivity subgroup analyses evaluate individual study contributions overall combined effect. Heterogeneity (I2) effect estimated 18 different species/active ingredient/IE concentration pairings. ranged 29.32 99.78% between subgroups, indicating inconsistency within The DL IE50 varied 0.048 ppb Cx. exposed 1.818 Ae. methoprene. certainty analysis indicated 1 value exhibited high certainty, 8 out pairings moderately certain, 6 low 3 very certainty. main causes uncertainty (ranked) studies, imprecision size, possible bias. Our findings indicate robust could be established all species/IGR pairings, providing essential substantial heterogeneity among laboratory colonies complicates detection field-collected mosquitoes; significant portion relies on mosquito strains are likely not fully susceptible, further complicating detection. registered supported by North Shore Mosquito Abatement District.

Language: Английский

Re-emergence of Oropouche virus between 2023 and 2024 in Brazil: an observational epidemiological study DOI Creative Commons
Gabriel C Scachetti, Julia Forato, Ingra Morales Claro

et al.

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Oropouche virus is an arthropod-borne that has caused outbreaks of fever in central and South America since the 1950s. This study investigates virological factors contributing to re-emergence Brazil between 2023 2024.

Language: Английский

Citations

27
Climate change, malaria and neglected tropical diseases: a scoping review DOI Creative Commons
Petra Klepac,

Jennifer L Hsieh,

Camilla Ducker

et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2024, Volume and Issue: 118(9), P. 561 - 579

Published: May 10, 2024

To explore the effects of climate change on malaria and 20 neglected tropical diseases (NTDs), potential effect amelioration through mitigation adaptation, we searched for papers published from January 2010 to October 2023. We descriptively synthesised extracted data. analysed numbers meeting our inclusion criteria by country national disease burden, healthcare access quality index (HAQI), as well vulnerability score. From 42 693 retrieved records, 1543 full-text were assessed. Of 511 criteria, 185 studied malaria, 181 dengue chikungunya 53 leishmaniasis; other NTDs relatively understudied. Mitigation was considered in 174 (34%) adaption strategies 24 (5%). Amplitude direction are likely vary location, be non-linear evolve over time. Available analyses do not allow confident prediction overall global impact these diseases. For group non-vector-borne NTDs, literature privileged consideration current low-burden countries with a high HAQI. No leishmaniasis outcomes East Africa. Comprehensive, collaborative standardised modelling efforts needed better understand how will directly indirectly affect NTDs.

Language: Английский

Citations

23
Progress and challenges in infectious disease surveillance and early warning DOI Creative Commons
Ying Shen, Youngjoon Hong, Thomas Krafft

et al.

Medicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100071 - 100071

Published: Jan. 1, 2025

Language: Английский

Citations

3
The anthropogenic fingerprint on emerging infectious diseases DOI Creative Commons
Rory Gibb, Sadie J. Ryan, David M. Pigott

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 22, 2024

Abstract Emerging infectious diseases are increasingly understood as a hallmark of the Anthropocene 1–3 . Most experts agree that anthropogenic ecosystem change and high-risk contact among people, livestock, wildlife have contributed to recent emergence new zoonotic, vector-borne, environmentally-transmitted pathogens 1,4–6 However, extent which these factors also structure landscapes human infection outbreak risk is not well understood, beyond certain well-studied disease systems 7–9 Here, we consolidate 58,319 unique records events for 32 emerging worldwide, systematically test influence 16 hypothesized social environmental drivers on geography risk, while adjusting multiple detection, reporting, research biases. Across diseases, risks widely associated with mosaic where people live alongside forests fragmented ecosystems, commonly exacerbated by long-term decreases in precipitation. The combined effects particularly strong vector-borne (e.g., Lyme dengue fever), underscoring policy strategies manage will need address land use climate 10–12 In contrast, find little evidence spillovers directly-transmitted zoonotic Ebola virus mpox) consistently factors, or other such deforestation agricultural intensification 13 importantly, observed spatial intensity primarily an artefact healthcare access, indicating existing surveillance remain insufficient comprehensive monitoring response: across reporting declined median 32% (range 1.2%-96.7%) each additional hour’s travel time from nearest health facility. Our findings underscore multicausal feature social-ecological systems, no one-size-fits-all global strategy can prevent epidemics pandemics. Instead, ecosystem-based interventions should follow regional priorities system-specific evidence, be paired investment One Health system strengthening.

Language: Английский

Citations

12
Emergence of a novel reassortant Oropouche virus drives persistent human outbreaks in the Brazilian Amazon region from 2022 to 2024 DOI Creative Commons
Felipe Gomes Naveca, Tatiana Amaral Pires de Almeida, Victor Costa de Souza

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 24, 2024

ABSTRACT The Brazilian western Amazon region is currently experiencing its largest laboratory confirmed Oropouche virus (OROV) outbreak, with nearly 6,000 reported cases in the states of Amazonas (AM), Acre (AC), Rondônia (RO), and Roraima (RR), between August 2022 March 2024. Here, we sequenced analyzed 382 full-length OROV genomes from human samples collected 2024 all four states, aiming to trace origin genetic evolution leading current outbreak. Genomic analyses revealed that recent upsurge coincides emergence a novel reassortant viral lineage containing M segment viruses detected eastern 2009 2018 L S segments Peru, Colombia, Ecuador 2008 2021. likely emerged Central AM state 2010 2014 displayed long-range silent dispersion during second half 2010s. 2022-2024 epidemic was spatially segregated into three major subpopulations located RR, AMACRO (a bordering AC, RO, AM-Southern region), AM-Central (which includes Amazonas’ capital, Manaus) regions. peak transmissions regions occurred rainy season basin. Furthermore, our phylodynamics reconstructions showed spread driven mainly by short-range (< 2 km) movements, an average dispersal rate ≤ 1.2 km/day, consistent pattern active flight infected vectors. Nevertheless, substantial proportion (22%) (> 10 migrations were also detected, via activities. Our data provides unprecedented view real-time neglected emergent pathogen. Moreover, results emphasize need for widespread, long-term genomic surveillance better understand real burden within beyond region.

Language: Английский

Citations

11
Variable surface antigen expression, virulence, and persistent infection by Plasmodium falciparum malaria parasites DOI

Evi Hadjimichael,

Kirk Deitsch

Microbiology and Molecular Biology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

SUMMARY The human malaria parasite Plasmodium falciparum is known for its ability to maintain lengthy infections that can extend over a year. This property derived from the parasite’s capacity continuously alter antigens expressed on surface of infected red blood cell, thereby avoiding antibody recognition and immune destruction. primary target system an antigen called PfEMP1 serves as cell receptor enables cells adhere vascular endothelium thus avoid filtration by spleen. genome encodes approximately 60 antigenically distinct forms PfEMP1, each encoded individual members multicopy var gene family. provides with repertoire antigenic types it systematically cycles through course infection, maintaining infection until exhausted. While this model variation based switching explains dynamics acute in individuals limited anti-malarial immunity, fails explain reports chronic, asymptomatic last decade. Recent field studies have led re-evaluation previous conclusions regarding prevalence chronic infections, application new technologies has provided insights into molecular mechanisms enable how these processes evolved.

Language: Английский

Citations

1
High-resolution spatiotemporal analysis of chikungunya epidemics between 2019 and 2020 in Salvador, Brazil: a municipality-level transmission dynamics study DOI
Hernán Darío Argibay, Cristiane Wanderley Cardoso, William Marciel de Souza

et al.

The Lancet Regional Health - Americas, Journal Year: 2025, Volume and Issue: 43, P. 101003 - 101003

Published: Jan. 24, 2025

Language: Английский

Citations

1
Relationship between meteorological factors and the incidence of severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis DOI Creative Commons

Guangju Mo,

Hongmei Zhu,

Jing Li

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 27, 2025

Language: Английский

Citations

1
Temperature sensing and virulence regulation in pathogenic bacteria DOI Creative Commons
Davide Roncarati, Andrea Vannini, Vincenzo Scarlato

et al.

Trends in Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Pathogenic bacteria can detect a variety of environmental signals, including temperature changes. While sudden and significant variations act as danger signals that trigger protective heat-shock response, minor fluctuations typically signal to the pathogen it has moved from one environment another, such entering specific niche within host during infection. These latter are utilized by pathogens coordinate expression crucial virulence factors. Here, we elucidate critical role in governing factors bacterial pathogens. Moreover, outline molecular mechanisms used fluctuations, focusing on systems employ proteins nucleic acids sensory devices. We also discuss potential implications extent risk climate change poses human pathogenic diseases.

Language: Английский

Citations

7
Leishmaniasis in Humans and Animals: A One Health Approach for Surveillance, Prevention and Control in a Changing World DOI Creative Commons
Claudia Cosma, Carla Maia, Nushrat Khan

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(11), P. 258 - 258

Published: Oct. 28, 2024

Leishmaniasis is classified as a neglected tropical disease (NTD), caused by protozoan parasites of the genus

Language: Английский

Citations

7