Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 21(7), P. 363 - 383

Published: March 30, 2020

Language: Английский

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Redox metabolism: ROS as specific molecular regulators of cell signaling and function

Molecular Cell, Journal Year: 2021, Volume and Issue: 81(18), P. 3691 - 3707

Published: Sept. 1, 2021

Language: Английский

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NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Oct. 7, 2020

Abstract Nicotinamide adenine dinucleotide (NAD + ) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells adapt environmental changes including nutrient perturbation, genotoxic factors, circadian disorder, infection, inflammation xenobiotics. These effects are mainly achieved by driving effect of NAD on metabolic pathways enzyme cofactors transferring hydrogen in oxidation-reduction reactions. Besides, multiple -dependent enzymes involved physiology either post-synthesis chemical modification DNA, RNA proteins, or releasing second messenger cyclic ADP-ribose (cADPR) NAADP . Prolonged disequilibrium metabolism disturbs physiological functions, resulting diseases diseases, cancer, aging neurodegeneration disorder. In this review, we summarize recent advances our understanding molecular mechanisms -regulated responses stresses, contribution deficiency various via manipulating cellular communication networks potential new avenues for therapeutic intervention.

Language: Английский

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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment

Trends in cancer, Journal Year: 2019, Volume and Issue: 5(8), P. 475 - 494

Published: Aug. 1, 2019

Language: Английский

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Circadian rhythm as a therapeutic target

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(4), P. 287 - 307

Published: Feb. 15, 2021

Language: Английский

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Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice

Science, Journal Year: 2022, Volume and Issue: 376(6598), P. 1192 - 1202

Published: May 5, 2022

Caloric restriction (CR) prolongs life span, yet the mechanisms by which it does so remain poorly understood. Under CR, mice self-impose chronic cycles of 2-hour feeding and 22-hour fasting, raising question if is calories, or time day that cause this increased span. We show here 30% CR was sufficient to extend span 10%; however, a daily fasting interval circadian alignment acted together 35% in male C57BL/6J mice. These effects were independent body weight. Aging induced widespread increases gene expression associated with inflammation decreases genes encoding components metabolic pathways liver from ad libitum-fed at night ameliorated these aging-related changes. Our results interventions promote longevity provide perspective further explore aging.

Language: Английский

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Lamina-associated domains: peripheral matters and internal affairs

Genome biology, Journal Year: 2020, Volume and Issue: 21(1)

Published: April 2, 2020

Abstract At the nuclear periphery, associations of chromatin with lamina through lamina-associated domains (LADs) aid functional organization genome. We review LADs and provide evidence LAD heterogeneity from cell ensemble single-cell data. are typically repressive environments in genome; nonetheless, we discuss findings lamin interactions regulatory elements active genes, role lamins may play genome regulation. address relationship between other organizers, involvement laminopathies. The current data lay basis for future studies on significance lamin-chromatin health disease.

Language: Английский

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Molecular regulations of circadian rhythm and implications for physiology and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Feb. 8, 2022

The term "circadian rhythms" describes endogenous oscillations with ca. 24-h period associated the earth's daily rotation and light/dark cycle. Such rhythms reflect existence of an intrinsic circadian clock that temporally orchestrates physiological processes to adapt internal environment external cues. At molecular level, consists multiple sets transcription factors resulting in autoregulatory transcription-translation feedback loops. Notably, addition their primary role as generator rhythm, biological plays a key controlling functions almost all tissues organs. It regulates several intracellular signaling pathways, ranging from cell proliferation, DNA damage repair response, angiogenesis, metabolic redox homeostasis, inflammatory immune response. In this review, we summarize findings showing crosstalk between some describing scenario wherein reciprocal regulation impinges upon aspects mammalian physiology. Moreover, based on evidence indicating can be challenged by environmental factors, social behaviors, well pre-existing pathological conditions, discuss implications misalignment human pathologies, such cancer diseases. Accordingly, disruption rhythm has been reported affect are relevant Expanding our understanding field represents intriguing transversal medicine challenge order establish precision medicine.

Language: Английский

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Making sense of the ageing methylome

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(10), P. 585 - 605

Published: May 2, 2022

Language: Английский

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Adverse Cardiovascular Effects of Traffic Noise with a Focus on Nighttime Noise and the New WHO Noise Guidelines

Annual Review of Public Health, Journal Year: 2020, Volume and Issue: 41(1), P. 309 - 328

Published: Jan. 10, 2020

Exposure to traffic noise is associated with stress and sleep disturbances. The World Health Organization (WHO) recently concluded that road increases the risk for ischemic heart disease potentially other cardiometabolic diseases, including stroke, obesity, diabetes. WHO report focused on whole-day exposure, but new epidemiological translational field studies indicate nighttime noise, in particular,is an important factor cardiovascular (CVD) through increased levels of hormones vascular oxidative stress, leading endothelial dysfunction subsequent development various CVDs. Novel experimental found be stress–induced brain damage, mediated by activation NADPH oxidase, uncoupling neuronal nitric oxide synthase, vascular/brain infiltration inflammatory cells. Noise-induced pathophysiology was more pronounced response as compared daytime noise. This review focuses consequences

Language: Английский

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