Quality control of the mitochondrial proteome

Nature Reviews Molecular Cell Biology, Journal Year: 2020, Volume and Issue: 22(1), P. 54 - 70

Published: Oct. 22, 2020

Language: Английский

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The emerging mechanisms and functions of microautophagy

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 24(3), P. 186 - 203

Published: Sept. 12, 2022

Language: Английский

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Phosphoinositides as membrane organizers

Nature Reviews Molecular Cell Biology, Journal Year: 2022, Volume and Issue: 23(12), P. 797 - 816

Published: May 19, 2022

Language: Английский

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Oxidative eustress: On constant alert for redox homeostasis

Redox Biology, Journal Year: 2021, Volume and Issue: 41, P. 101867 - 101867

Published: Jan. 20, 2021

In the open metabolic system, redox-related signaling requires continuous monitoring and fine-tuning of steady-state redox set point. The ongoing oxidative metabolism is a persistent challenge, denoted as eustress, which operates within physiological range that has been called 'Homeodynamic Space', 'Goldilocks Zone' or 'Golden Mean'. Spatiotemporal control achieved by compartmentalized generation removal oxidants. cellular landscape H2O2, major molecule, characterized orders-of-magnitude concentration differences between organelles. This pattern mirrored oxidatively modified proteins, exemplified S-glutathionylated proteins. review presents conceptual background for short-term (non-transcriptional) longer-term (transcriptional/translational) homeostatic mechanisms stress responses. point variable moving target value, modulated circadian rhythm external influence, summarily exposome, includes nutrition lifestyle factors. Emerging fields cell-specific tissue-specific regulation in settings are briefly presented, including new insight into role eustress embryonal development lifespan, skeletal muscle exercise, sleep-wake rhythm, function nervous system with aspects leading to psychobiology.

Language: Английский

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LRRK2 mediates tubulation and vesicle sorting from lysosomes

Science Advances, Journal Year: 2020, Volume and Issue: 6(46)

Published: Nov. 12, 2020

The Parkinson disease kinase LRRK2 translocates to the lysosomal membrane triggering sorting through JIP4.

Language: Английский

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The role of mitochondrial fission in cardiovascular health and disease

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 19(11), P. 723 - 736

Published: May 6, 2022

Language: Английский

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Rationalized deep learning super-resolution microscopy for sustained live imaging of rapid subcellular processes

Nature Biotechnology, Journal Year: 2022, Volume and Issue: 41(3), P. 367 - 377

Published: Oct. 6, 2022

Language: Английский

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Lipid Droplet Contact Sites in Health and Disease

Trends in Cell Biology, Journal Year: 2021, Volume and Issue: 31(5), P. 345 - 358

Published: Feb. 3, 2021

Language: Английский

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Volume electron microscopy

Nature Reviews Methods Primers, Journal Year: 2022, Volume and Issue: 2(1)

Published: July 7, 2022

Language: Английский

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Fundamentals of redox regulation in biology

Nature Reviews Molecular Cell Biology, Journal Year: 2024, Volume and Issue: 25(9), P. 701 - 719

Published: April 30, 2024

Language: Английский

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