Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156445 - 156445
Published: Feb. 2, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 7, 2025
Redox signaling acts as a critical mediator in the dynamic interactions between organisms and their external environment, profoundly influencing both onset progression of various diseases. Under physiological conditions, oxidative free radicals generated by mitochondrial respiratory chain, endoplasmic reticulum, NADPH oxidases can be effectively neutralized NRF2-mediated antioxidant responses. These responses elevate synthesis superoxide dismutase (SOD), catalase, well key molecules like nicotinamide adenine dinucleotide phosphate (NADPH) glutathione (GSH), thereby maintaining cellular redox homeostasis. Disruption this finely tuned equilibrium is closely linked to pathogenesis wide range Recent advances have broadened our understanding molecular mechanisms underpinning dysregulation, highlighting pivotal roles genomic instability, epigenetic modifications, protein degradation, metabolic reprogramming. findings provide foundation for exploring regulation mechanistic basis improving therapeutic strategies. While antioxidant-based therapies shown early promise conditions where stress plays primary pathological role, efficacy diseases characterized complex, multifactorial etiologies remains controversial. A deeper, context-specific signaling, particularly redox-sensitive proteins, designing targeted aimed at re-establishing balance. Emerging small molecule inhibitors that target specific cysteine residues proteins demonstrated promising preclinical outcomes, setting stage forthcoming clinical trials. In review, we summarize current intricate relationship disease also discuss how these insights leveraged optimize strategies practice.
Language: Английский
Citations
4
Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 104 - 104
Published: Jan. 17, 2025
Breast cancer is one of the most prevalent cancers worldwide. Recent studies have increasingly emphasized role oxidative stress in initiation and progression breast cancer. This article reviews how imbalance influences occurrence advancement cancer, elucidating intricate mechanisms through which reactive oxygen species (ROS) operate this context their potential therapeutic applications. By highlighting these critical insights, review aims to enhance our understanding as a target for innovative strategies management
Language: Английский
Citations
3
Foods, Journal Year: 2025, Volume and Issue: 14(4), P. 564 - 564
Published: Feb. 8, 2025
In this study, Chinese yam polysaccharide (CYP) was fermented by Saccharomyces cerevisiae CICC 32883, and its structural features antioxidant activities before after fermentation were analyzed. S. 32883-fermented CYP (CYP-SC) had higher carbohydrate content lower protein than the nonfermented (CYP-NF). The monosaccharide composition of CYP-SC unaffected, but proportion changed. Compared with CYP-NF's molecular weight polydispersity 124.774 kDa 6.58, respectively, those reduced to 20.384 3.379. Antioxidant results showed that better effects CYP-NF in scavenging DPPH, ABTS, hydroxyl, superoxide radicals. Moreover, enhancing oxidation capacity protecting HepG2 cells CYP-NF. Furthermore, on alleviating repairing H2O2-damaged are superior This work offers a green efficient method for activity dietary plant polysaccharides.
Language: Английский
Citations
3
Processes, Journal Year: 2025, Volume and Issue: 13(1), P. 277 - 277
Published: Jan. 20, 2025
The generation of hydrogen peroxide has been documented in various plant-based beverages, such as coffee, tea, herbal infusions and wine, well energy drinks containing ascorbate food. There are no data the literature on presence beer strong alcoholic beverages plant material. This study aimed to examine whether selected (brandy, whisky fruit liqueurs) contain peroxide. was found freshly opened brandy, whisky, liqueurs most diluted beers; subsequent incubation an air atmosphere led electron paramagnetic resonance (EPR) signal semiquinone radical superoxide demonstrated by dismutase-inhibitable reduction Nitrotetrazolium Blue oxidation dihydroethidium agreement with two-step mechanism autoxidation phenolics. These results broaden list producing
Language: Английский
Citations
2
Published: Feb. 1, 2025
Language: Английский
Citations
2
Chemical Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
A chemically modified DNAzyme-based electrochemical sensor was developed for binary and highly sensitive detection of reactive oxygen species.
Language: Английский
Citations
1
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Anemia is a potentially life-threatening blood disorder caused by an insufficient erythroblast volume in the circulatory system. Self-renewal failure of progenitors one key pathological factors leading to deficiency. However, there are currently no effective drugs that selectively target this process. In work, we present carbon dot (CP-CDs) derived from phytochemicals significantly promotes self-renewal for anemia therapy. As superoxide dismutase (SOD)-like nanozyme, CP-CDs activate hypoxia response and JAK/STAT3 pathways erythroid cells reprogramming oxidative stress state. This results unique erythropoiesis-enhancing properties promoting generation progenitor cells. Moreover, protect mature red inhibiting stress-induced damage improving immune-inflammatory microenvironment. vivo, showed promising therapeutic effect mouse zebrafish models with minimal adverse effects, indicating significant translational medical value. Collectively, study not only illustrates successful approach nanomedicine-enhanced therapy but also enhances our understanding interaction between nanomedicine progenitors.
Language: Английский
Citations
1
ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 31, 2025
The regulation of oxidative stress in living cells is essential for maintaining cellular processes and signal transduction. However, developing straightforward strategies to activate stress-sensitive membrane channels situ poses significant challenges. In this study, we present a chemiluminescence resonance energy transfer (CRET) system based on conjugated oligomer, oligo(p-phenylenevinylene)-imidazolium (OPV-Im), designed the activation transient receptor potential melastatin 2 (TRPM2) calcium by superoxide anion (O2⋅-) without requiring external light sources. OPV-Im oligomer targeted cell efficiently, leading TRPM2 CRET process subsequent intracellular overload. This cascade resulted mitochondrial damage inhibition autophagy, ultimately inducing apoptosis. Additionally, strategy could be applied selective killing tumor that overexpress ion inhibiting growth three-dimensional (3D) spheroids. Our offers novel approach regulating channel activity compared optogenetics photodynamic therapy.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2622 - 2622
Published: March 14, 2025
Reactive oxygen species (ROS) are widely considered key to pathogenesis in chronic metabolic disease. Consequently, much attention is rightly focused on minimising oxidative damage. However, for ROS production be most effectively modulated, it crucial first appreciate that do not solely function as pathological mediators. There >90 gene products specifically evolved generate, handle, and tightly buffer the cellular concentration of ROS. Therefore, likely plays a role integral homeostatic signalling components only become toxic extremis. This review explores these commonly overlooked normal physiological functions, including how generated response environmental or hormonal stimuli, mechanisms by which signals propagated regulated, cell brings signal an end after appropriate duration. In course this, several specific better-characterised rely upon explored, threshold at cross from beneficial molecules pathology mediators discussed.
Language: Английский
Citations
1