Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
273, P. 116098 - 116098
Published: Feb. 17, 2024
Plastic
waste
accumulation
and
its
degradation
into
microplastics
(MPs)
nanoplastics
(NPs)
pose
environmental
concerns.
Previous
studies
have
indicated
that
polystyrene
(PS)-MPs
harm
living
animals.
Extracellular
vesicles
(EVs)
are
associated
with
metabolic
reprogramming
mitochondrial
dysfunction
in
various
kidney
diseases.
In
this
article,
we
evaluated
how
PS-MPs
affected
tubular
cells
fibroblasts.
The
results
demonstrated
increased
EV
production
human
caused
endoplasmic
reticulum
(ER)
stress-related
proteins
without
inducing
inflammation-related
cells.
uptake
of
incubation
the
conditioned
medium
induced
reactive
oxygen
species
(ROS)
ER
fibroblast
treated
also
expression
fibrosis-related
proteins.
Our
findings
suggested
EV-related
markers
via
Beclin
1
after
PS-MP
treatment.
addition,
ROS
vitro
vivo.
We
found
altered
urine,
CD63
was
vivo
conclusion,
PS-MP-induced
EVs
lead
to
proteins,
Cancers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 807 - 807
Published: Feb. 16, 2024
Epithelial
Mesenchymal
Transition
(EMT)
is
a
dedifferentiation
process
implicated
in
many
physio-pathological
conditions
including
tumor
transformation.
EMT
regulated
by
several
extracellular
mediators
and
under
certain
it
can
be
reversible.
Autophagy
conserved
catabolic
which
intracellular
components
such
as
protein/DNA
aggregates
abnormal
organelles
are
degraded
specific
lysosomes.
In
cancer,
autophagy
plays
controversial
role,
acting
different
both
suppressor
tumor-promoting
mechanism.
Experimental
evidence
shows
that
deep
interrelations
exist
between
autophagy-related
pathways.
Although
this
interplay
has
already
been
analyzed
previous
studies,
understanding
mechanisms
the
translational
implications
of
autophagy/EMT
need
further
study.
The
role
not
limited
to
morphological
changes,
but
activation
could
important
DNA
repair/damage
system,
cell
adhesion
molecules,
proliferation
differentiation
processes.
Based
on
this,
related
pathways
now
considered
targets
for
cancer
therapy.
review
article,
contribution
progression
discussed.
This
article
also
describes
multiple
connections
their
implication
treatment.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(9)
Published: Sept. 1, 2024
Abstract
Cell
death
regulation
is
essential
for
tissue
homeostasis
and
its
dysregulation
often
underlies
cancer
development.
Understanding
the
different
pathways
of
cell
can
provide
novel
therapeutic
strategies
battling
cancer.
This
review
explores
several
key
mechanisms
apoptosis,
necroptosis,
autophagic
death,
ferroptosis,
pyroptosis.
The
research
gap
addressed
involves
a
thorough
analysis
how
these
be
precisely
targeted
therapy,
considering
tumor
heterogeneity
adaptation.
It
delves
into
genetic
epigenetic
factors
signaling
cascades
like
phosphatidylinositol
3‐kinase/protein
kinase
B/mammalian
target
rapamycin
(PI3K/AKT/mTOR)
mitogen‐activated
protein
kinase/extracellular
signal‐regulated
(MAPK/ERK)
pathways,
which
are
critical
death.
Additionally,
interaction
microenvironment
with
cells,
particularly
influence
hypoxia,
nutrient
deprivation,
immune
cellular
interactions,
explored.
Emphasizing
strategies,
this
highlights
emerging
modulators
inducers
such
as
B
lymphoma
2
(BCL2)
homology
domain
3
(BH3)
mimetics,
tumour
necrosis
factor‐related
apoptosis‐inducing
ligand
(TRAIL),
chloroquine,
innovative
approaches
to
induce
ferroptosis
provides
insights
therapy's
future
direction,
focusing
on
multifaceted
circumvent
drug
resistance.
examination
evolving
underlines
considerable
clinical
potential
continuous
necessity
in‐depth
exploration
within
scientific
domain.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
273, P. 116098 - 116098
Published: Feb. 17, 2024
Plastic
waste
accumulation
and
its
degradation
into
microplastics
(MPs)
nanoplastics
(NPs)
pose
environmental
concerns.
Previous
studies
have
indicated
that
polystyrene
(PS)-MPs
harm
living
animals.
Extracellular
vesicles
(EVs)
are
associated
with
metabolic
reprogramming
mitochondrial
dysfunction
in
various
kidney
diseases.
In
this
article,
we
evaluated
how
PS-MPs
affected
tubular
cells
fibroblasts.
The
results
demonstrated
increased
EV
production
human
caused
endoplasmic
reticulum
(ER)
stress-related
proteins
without
inducing
inflammation-related
cells.
uptake
of
incubation
the
conditioned
medium
induced
reactive
oxygen
species
(ROS)
ER
fibroblast
treated
also
expression
fibrosis-related
proteins.
Our
findings
suggested
EV-related
markers
via
Beclin
1
after
PS-MP
treatment.
addition,
ROS
vitro
vivo.
We
found
altered
urine,
CD63
was
vivo
conclusion,
PS-MP-induced
EVs
lead
to
proteins,
