Curcumin enhances ATG3-dependent autophagy and inhibits metastasis in cervical carcinoma DOI Creative Commons
Fei Zheng, Jingjing Lu, Chuhan Wang

et al.

Cell Division, Journal Year: 2024, Volume and Issue: 19(1)

Published: Nov. 28, 2024

Cervical carcinoma poses a significant health threat, with traditional treatments proving inadequate in advanced stages. Curcumin, bioactive compound derived from turmeric, exhibits notable anti-inflammatory, antioxidant, and antineoplastic properties, potentially modulating autophagy, metastasis cancer cells. This study examines curcumin's impact on autophagy cervical carcinoma, focusing its interaction autophagy-related gene 3 (ATG3). SiHa HeLa cell lines were treated curcumin, ATG3 knockdown (shATG3), their combination. Cell migration was evaluated via wound healing assays, while proliferation CCK-8 assays. LC3 expression assessed using immunofluorescence western blotting. Molecular docking simulations identified binding interactions key proteins. Curcumin shATG3 significantly inhibited both proliferation, synergistic effect observed when combined. enhanced, indicating increased autophagy. Docking studies revealed potential to MMP2, MMP9, TGF-β, ATG3, LC3, p62, suggesting modulation of these pathways. The combination curcumin also enhancing supporting the as therapeutic agent for carcinoma. Further clinical research is needed validate findings.

Language: Английский

Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer DOI Creative Commons
Xiaoli Zeng, Yue Chen, Jing Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, catabolic process induced under stress conditions, has been shown to play dual role in oral development therapy. Recent studies have identified that autophagy activation epithelial cells suppresses cell survival inhibiting key pathways such as the mammalian target of rapamycin (mTOR) mitogen-activated protein kinase (MAPK), while activating adenosine monophosphate-activated (AMPK) pathway. Inducing promotes degradation eukaryotic initiation factor 4E, thus reducing metastasis enhancing efficacy chemotherapy, radiotherapy, immunotherapy. Furthermore, induction can modulate tumor immune microenvironment enhance antitumor immunity. This review comprehensively summarizes relationship between cancer, focusing on its mechanisms therapeutic potential when combined with conventional treatments. While promising, precise clinical applications inducers therapy remain be elucidated, offering new directions for future research improve treatment outcomes reduce recurrence.

Language: Английский

Citations

1
Deciphering the Role of Cancer Stem Cells: Drivers of Tumor Evolution, Therapeutic Resistance, and Precision Medicine Strategies DOI Open Access
Mohamed El‐Tanani, Syed Arman Rabbani, Shakta Mani Satyam

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 382 - 382

Published: Jan. 24, 2025

Cancer stem cells (CSCs) play a central role in tumor progression, recurrence, and resistance to conventional therapies, making them critical focus oncology research. This review provides comprehensive analysis of CSC biology, emphasizing their self-renewal, differentiation, dynamic interactions with the microenvironment (TME). Key signaling pathways, including Wnt, Notch, Hedgehog, are discussed detail highlight potential as therapeutic targets. Current methodologies for isolating CSCs critically examined, addressing advantages limitations advancing precision medicine. Emerging technologies, such CRISPR/Cas9 single-cell sequencing, explored transformative unraveling heterogeneity informing strategies. The also underscores pivotal TME supporting survival, promoting metastasis, contributing resistance. Challenges arising from CSC-driven dormancy analyzed, along strategies mitigate these barriers, novel therapeutics targeted approaches. Ethical considerations integration artificial intelligence designing CSC-specific therapies essential elements future manuscript advocates multi-disciplinary approach that combines innovative advanced therapeutics, collaborative research address complexities CSCs. By bridging existing gaps knowledge fostering advancements personalized medicine, this aims guide development more effective cancer treatment strategies, ultimately improving patient outcomes.

Language: Английский

Citations

1
Manzamine A: A Promising Marine-Derived Cancer Therapeutic for Multi-targeted Interactions with E2F8, SIX1, AR, GSK-3β, and V-ATPase - A Systematic Review DOI Creative Commons
Mohammad Amir Mishan, Yeun‐Mun Choo,

Jeffery Winkler

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177295 - 177295

Published: Jan. 1, 2025

Language: Английский

Citations

0
Malignancy in systemic lupus erythematosus: relation to disease characteristics in 92 patients – a single center retrospective study DOI Creative Commons
Joanna Kosałka-Węgiel, Renata Pacholczak‐Madej, Radosław Dziedzic

et al.

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(9), P. 1701 - 1713

Published: June 8, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with variable clinical manifestation, potentially leading to death. Importantly, patients SLE have an increased risk of neoplastic disorders. Thus, this study aimed comprehensively evaluate the and laboratory characteristics or without malignancy.

Language: Английский

Citations

3
Targeting Ferroptosis as an Advance Strategy in Cancer Therapy DOI
Tobias Achu Muluh, Qianqian Fu,

Xiaojiao Ai

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: 41(10-12), P. 616 - 636

Published: July 3, 2024

This study innovates by systematically integrating the molecular mechanisms of iron death and its application in cancer therapy. By deeply analyzing interaction between tumor microenvironment, provides a new theoretical basis for treatment directions developing more effective strategies. In addition, points to critical issues barriers that need be addressed future research, providing valuable insights into use clinical translation.

Language: Английский

Citations

3
Exploring Importance and Regulation of Autophagy in Cancer Stem Cells and Stem Cell-Based Therapies DOI Creative Commons
Md. Ataur Rahman, Ehsanul Hoque Apu, S M Rakib-Uz-Zaman

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(11), P. 958 - 958

Published: June 1, 2024

Autophagy is a globally conserved cellular activity that plays critical role in maintaining homeostasis through the breakdown and recycling of constituents. In recent years, there has been much emphasis given to its complex cancer stem cells (CSCs) cell treatment. This study examines molecular processes support autophagy how it regulated context CSCs Although dual management CSCs, affecting their removal as well maintenance, intricate interaction between several signaling channels control survival death part mechanism not elucidated. Given have development, progression, resistance treatment tumors, imperative comprehend biological activities. are important for biology because they also show tissue regeneration model helps with organoid regeneration. other words, manipulation viable therapeutic approach therapy. Both synthetic natural substances target pathways demonstrated promise improving cell-based therapies eliminating CSCs. Nevertheless, difficulties associated limitations CSC regulation, including mechanisms off-target effects. Thus, regulation offers versatile strategy focusing on enhancing results Therefore, understanding interactions would be essential creating treatments work both regenerative medicine

Language: Английский

Citations

2
The role of epithelial-mesenchymal transition in pulmonary fibrosis: lessons from idiopathic pulmonary fibrosis and COVID-19 DOI Creative Commons

Reyhaneh Niayesh‐Mehr,

Mojtaba Kalantar, Giulio Bontempi

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 13, 2024

Despite the tremendous advancements in knowledge of pathophysiology and clinical aspects SARS-CoV-2 infection, still many issues remain unanswered, especially long-term effects. Mounting evidence suggests that pulmonary fibrosis (PF) is one most severe complications associated with COVID-19. Therefore, understanding molecular mechanisms behind its development helpful to develop successful therapeutic strategies. Epithelial mesenchymal transition (EMT) cell specific variants endothelial (EndMT) mesothelial (MMT) are physio-pathologic cellular reprogramming processes induced by several infectious, inflammatory biomechanical stimuli. Cells undergoing EMT acquire invasive, profibrogenic proinflammatory activities secreting extracellular mediators. Their activity has been implicated pathogenesis PF a variety lung disorders, including idiopathic (IPF) Aim this article provide an updated survey mechanisms, emphasis on EMT-related processes, genesis IFP

Language: Английский

Citations

2
Rhus coriaria induces autophagic and apoptotic cell death in pancreatic cancer cells DOI Creative Commons

Y. El Mahi,

Zohra Nausheen Nizami, Adil Farooq Wali

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

Pancreatic cancer is a leading cause of cancer-related mortality worldwide with increasing global incidence. We previously reported the anticancer effect

Language: Английский

Citations

1
MiR-29a-laden extracellular vesicles efficiently induced apoptosis through autophagy blockage in HCC cells DOI

Homeyra Seydi,

Kosar Nouri,

Bahare Shokouhian

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 203, P. 114470 - 114470

Published: Aug. 26, 2024

Language: Английский

Citations

1
Curcumin Enhances ATG3-Dependent Autophagy and Inhibits Metastasis in Cervical Carcinoma DOI Creative Commons
Fei Zheng, Jingjing Lu, Chuhan Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 25, 2024

Abstract Cervical carcinoma poses a significant health threat, with traditional treatments proving inadequate in advanced stages. Curcumin, bioactive compound derived from turmeric, exhibits notable anti-inflammatory, antioxidant, and antineoplastic properties, potentially modulating autophagy, metastasis cancer cells. This study examines curcumin's impact on autophagy cervical carcinoma, focusing its interaction autophagy-related gene 3 (ATG3). SiHa HeLa cell lines were treated curcumin, ATG3 knockdown (shATG3), their combination. Cell migration was evaluated via wound healing assays, LC3 expression assessed using immunofluorescence western blotting. Molecular docking simulations identified binding interactions key proteins. Curcumin shATG3 significantly inhibited migration, synergistic effect observed when combined. enhanced, indicating increased autophagy. Docking studies revealed potential to MMP2, MMP9, TGF-β, ATG3, LC3, p62, suggesting modulation of these pathways. The combination curcumin demonstrates inhibition enhancement supporting as therapeutic agent for carcinoma. Further clinical research is warranted confirm findings.

Language: Английский

Citations

0