Human Gene Therapy,
Journal Year:
2024,
Volume and Issue:
35(5-6), P. 139 - 150
Published: Feb. 22, 2024
Inherited
kidney
diseases
are
among
the
leading
causes
of
chronic
disease,
reducing
quality
life
and
resulting
in
substantial
socioeconomic
impact.
The
advent
early
genetic
testing
growing
understanding
molecular
basis
pathophysiology
these
disorders
have
opened
avenues
for
novel
treatment
strategies.
Viral
vector-based
gene
therapies
evolved
from
experimental
treatments
rare
to
potent
platforms
that
carry
intrinsic
potential
provide
a
cure
with
single
application.
Several
therapy
products
reached
market,
numbers
only
expected
increase.
Still,
none
target
inherited
diseases.
Gene
transfer
has
lagged
when
compared
other
tissue-directed
such
as
hepatic,
neuromuscular,
ocular
tissues.
Systemic
delivery
information
tackle
disease
is
challenging.
pharma
industry
taking
steps
take
on
translate
current
research
into
therapeutic
arena.
In
this
review,
we
an
overview
viral
approaches
their
potential.
We
discuss
advances
injection
routes
been
explored
enhance
toward
cells
animal
models,
how
can
fuel
development
viable
humans.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 12, 2023
Abstract
Natural
living
materials
serving
as
biotherapeutics
exhibit
great
potential
for
treating
various
diseases
owing
to
their
immunoactivity,
tissue
targeting,
and
other
biological
activities.
In
this
review,
the
recent
developments
in
engineered
materials,
including
mammalian
cells,
bacteria,
viruses,
fungi,
microalgae,
plants,
active
derivatives
that
are
used
summarized.
Further,
future
perspectives
challenges
of
such
material‐based
discussed
provide
considerations
advances
biomedical
applications.
Chinese Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Feb. 12, 2025
Abstract
In
the
past
few
years,
emergence
of
organoids
and
organ-on-a-chip
(OOAC)
technologies,
which
are
complementary
to
animal
models
two-dimensional
cell
culture
methods
can
better
simulate
internal
environment
human
body,
provides
a
new
platform
for
traditional
Chinese
medicine
(TCM)
studies.
Organoids
OOAC
techniques
have
been
increasingly
applied
in
fields
drug
screening,
assessment
development,
personalized
therapies,
developmental
biology,
there
some
application
cases
TCM
this
review,
we
summarized
current
status
using
organoid
technologies
research
provide
key
insights
future
study.
It
is
believed
that
will
play
more
important
roles
make
greater
contributions
innovative
development
TCM.
Journal of Clinical Investigation,
Journal Year:
2024,
Volume and Issue:
134(17)
Published: Aug. 15, 2024
Adeno-associated
virus
(AAV)
is
a
promising
in
vivo
gene
delivery
platform
showing
advantages
delivering
therapeutic
molecules
to
difficult
or
undruggable
cells.
However,
natural
AAV
serotypes
have
insufficient
transduction
specificity
and
efficiency
kidney
Here,
we
developed
an
evolution-directed
selection
protocol
for
renal
glomeruli
identified
what
believe
be
new
vector
termed
AAV2-GEC
that
specifically
efficiently
targets
the
glomerular
endothelial
cells
(GEC)
after
systemic
administration
maintains
robust
GEC
tropism
healthy
diseased
rodents.
AAV2-GEC-mediated
of
IdeS,
bacterial
antibody-cleaving
proteinase,
provided
sustained
clearance
kidney-bound
antibodies
successfully
treated
antiglomerular
basement
membrane
glomerulonephritis
mice.
Taken
together,
this
study
showcases
potential
as
challenging
cell
types.
The
development
its
successful
application
treatment
antibody-mediated
disease
represents
significant
step
forward
opens
up
avenues
medicine.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
15
Published: Jan. 14, 2025
Renal
fibrosis
is
one
of
the
main
pathological
features
chronic
kidney
disease
(CKD),
and
its
treatment
has
been
a
hot
research
topic.
Recent
studies
have
shown
that
stem
cell
therapy
can
repair
renal
changes
slow
progression
CKD.
In
addition,
large
number
experiments
confirmed
traditional
Chinese
medicine
(TCM),
especially
compound
preparations,
advantage
multitargeting
interventions
to
improve
fibrosis.
Therefore,
combined
with
TCM
expected
provide
new
therapeutic
ideas
measures
solve
problems.
This
article
reviews
current
status
for
CKD,
discusses
existing
problems,
proposes
future
prospects.
