Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
unknown, P. 101735 - 101735
Published: April 1, 2025
This
Review
explores
the
growing
and
diversifying
field
of
tissue-derived
abiotic
constructs
for
tissue
engineering
applications,
with
main
focus
on
decellularization
devitalization
techniques
principles.
Acellular
fractions
derived
from
biological
tissues,
such
as
extracellular
matrix
(ECM),
have
long
been
considered
a
valuable
approach
generation
numerous
scaffolds
more
complex
constructs.
The
removal
cellular
content
has
essential
to
prevent
development
adverse
immunological
reactions.
Nevertheless,
discovery
promising
features
certain
components
sparked
interest
in
use
inactivated
or
devitalized
several
particularly
regenerative
medicine
inflammation
control.
Devitalization
described
clinical
but
remains
poorly
explored
terms
vitro
compared
methods
currently
available.
In
this
review,
we
present
critically
evaluate
spectrum
approaches
whole-organs
constructs,
most
prevalent
techniques,
discussion
their
implications
composition,
structure,
potentially
therapeutic
properties.
Processing
methodologies
achieve
optimal
cell-based
materials
effective
characterization
are
discussed.
application
these
healthcare,
including
examples
commercially
available
products,
is
also
addressed.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Aug. 17, 2023
Diabetic
foot
ulcer
(DFU)
is
a
major
complication
of
diabetes
and
associated
with
high
risk
lower
limb
amputation
mortality.
During
their
lifetime,
19%–34%
patients
can
develop
DFU.
It
estimated
that
61%
DFU
become
infected
15%
those
require
amputation.
Furthermore,
developing
increases
the
mortality
by
50%–68%
at
5
years,
higher
than
some
cancers.
Current
standard
management
includes
surgical
debridement,
use
topical
dressings
wound
decompression,
vascular
assessment,
glycemic
control.
Among
these
methods,
local
treatment
builds
protective
physical
barrier,
maintains
moist
environment,
drains
exudate
from
wounds.
This
review
summarizes
development,
pathophysiology,
healing
mechanisms
The
latest
research
progress
main
application
in
laboratory
clinical
stage
are
also
summarized.
discussed
this
include
traditional
(gauze,
oil
yarn,
Chinese
medicine,
others),
basic
(hydrogel,
hydrocolloid,
sponge,
foam,
film
agents,
bacteriostatic
dressings,
composite
(collagen,
nanomaterials,
chitosan
bioactive
(scaffold
stem
cells,
decellularized
matrix,
autologous
platelet
enrichment
plasma,
modern
technology
(3D
bioprinting,
photothermal
effects,
bioelectric
microneedle
smart
bandages,
orthopedic
prosthetics
regenerative
medicine).
dressing
challenges
limitations
purpose
to
help
readers
understand
pathogenesis
mechanism
DFU,
physicians
select
correctly,
provide
an
updated
overview
potential
biomaterials
devices
management,
ideas
for
further
exploration
development
dressings.
Proper
promote
healing,
reduce
cost
treating
patient
pain.
Biological
carriers
have
emerged
as
significant
tools
to
deliver
radionuclides
in
nuclear
medicine,
providing
a
meaningful
perspective
for
tumor
imaging
and
treatment.
Various
radionuclide-labeled
biological
been
developed
meet
the
needs
of
biomedical
applications.
This
review
introduces
principles
radionuclide-mediated
therapy
selected
criteria
them,
well
comprehensive
description
characteristics
functions
representative
including
bacteria,
cells,
viruses,
their
derivatives,
emphasizing
labeled
strategies
combined
with
radionuclides.
Subsequently,
we
in-depth
introduce
application
treatment,
behaviors
vivo
metastasis
treatment
by
radionuclide
therapy,
plus
other
radiation-induced
photodynamic
therapy.
Finally,
challenges
prospects
are
discussed
improve
shortcomings
this
innovative
platform
promote
clinical
transformation
field
medical
imaging.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 20, 2025
Hypoxia-related
adenosine
(Ado)
exerts
an
immunosuppressive
effect
in
tumors
by
binding
to
the
metabolic
checkpoint
Ado
A2A
receptors
(A2AR),
thereby
hindering
activation
of
antitumor
immunity
induced
immunogenic
cell
death
(ICD).
In
this
study,
a
MnO2-assisted
photosynthetic
bacteria
(PSB)
biohybrid
(MnO2@PSB)
is
developed
enhance
tumor
photothermal
immunotherapy
interfering
with
Ado-A2AR
pathway.
Specifically,
manganese
dioxide
(MnO2)
nanoflowers
are
conjugated
onto
PSB
carbodiimide
reaction
construct
MnO2@PSB.
As
agent,
MnO2@PSB
generates
heat
"burn"
cells
under
808
nm
laser
irradiation,
inducing
ICD.
Meanwhile,
catalyzes
decomposition
endogenous
hydrogen
peroxide
into
oxygen
alleviate
hypoxia,
reducing
production
and
downregulating
expression
A2AR,
further
reversing
microenvironment
amplifying
ICD
effects.
various
mouse
4T1
models,
can
immune
responses,
prolong
survival,
significantly
inhibit
growth,
recurrence,
metastasis
irradiation.
Collectively,
study
provides
direction
for
enhanced
through
regulating
pathways.
Nanoscale,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Biological
barriers
significantly
impede
the
delivery
of
nanotherapeutics
to
diseased
tissues,
diminishing
therapeutic
efficacy
across
pathologies
such
as
cancer
and
inflammatory
disorders.
Although
conventional
strategies
integrate
multifunctional
designs
molecular
components
into
nanomaterials
(NMs),
many
approaches
remain
insufficient
overcome
these
barriers.
Key
challenges,
including
inadequate
drug
accumulation
at
target
sites
nonspecific
biodistribution,
persist
in
nanotherapeutic
development.
NMs,
which
harness
ability
precisely
modulate
spatiotemporally
control
release
kinetics,
represent
a
transformative
platform
for
targeted
therapy.
In
this
review,
we
highlight
biological
obstacles
limiting
effective
treatment
evaluate
how
stimuli-responsive
NMs
address
constraints.
By
leveraging
exogenous
endogenous
stimuli,
improve
specificity,
reduce
off-target
effects,
amplify
activity
within
pathological
microenvironments.
We
systematically
analyze
rational
design
synthesis
driven
by
advances
oncology,
biomaterials
science,
nanoscale
engineering.
Furthermore,
NM
classes-including
polymeric,
lipid-based,
inorganic,
hybrid
systems
explore
functionalization
using
targeting
ligands,
antibodies,
biomimetic
coatings.
Diverse
are
evaluated,
small-molecule
prodrug
activation,
peptide-
protein-based
targeting,
nucleic
acid
payloads,
engineered
cell-mediated
transport.
Despite
promise
challenges
biocompatibility,
scalable
fabrication,
clinical
translation
must
be
addressed.
elucidating
structure-function
relationships
refining
stimulus-triggered
mechanisms,
pave
way
precision
oncology
strategies,
enabling
patient-specific
therapies
with
enhanced
safety.
This
interdisciplinary
insights
aims
catalyze
innovation
next-generation
nanomedicine
treatment.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(5)
Published: Oct. 4, 2023
Probiotics
have
the
potential
as
biotherapeutic
agents
for
cancer
management
in
preclinical
models
and
human
trials
by
secreting
antineoplastic
or
immunoregulatory
tumor
microenvironment
(TME).
However,
current
probiotics
lack
ability
to
dynamically
respond
unique
TME
characteristics,
leading
limited
therapeutic
accuracy
efficacy.
Although
progress
has
been
made
customizing
controllable
through
synthetic
biology,
engineering
process
is
complex
predictability
of
production
relatively
low.
To
address
this,
here,
first
time,
this
work
adopts
pH-dependent
peroxidase-like
(POD-like)
artificial
enzymes
both
an
inducible
"nano-promoter"
"nano-effector"
engineer
clinically
relevant
achieve
switchable
control
probiotic
therapy.
The
nanozyme
initially
serves
"nano-promoter,"
generating
trace
amounts
nonlethal
reactive
oxygen
species
(ROS)
stress
upregulate
acidic
metabolites
probiotics.
Once
acidify
a
threshold,
switches
"nano-effector,"
producing
great
deal
lethal
ROS
fight
cancer.
This
approach
shows
promise
subcutaneous,
orthotopic,
colitis-associated
colorectal
tumors,
offering
new
methodology
modulating
metabolism
pathological
environment.
Bioengineering,
Journal Year:
2024,
Volume and Issue:
11(4), P. 311 - 311
Published: March 26, 2024
Magnetic
robots
possess
an
innate
ability
to
navigate
through
hard-to-reach
cavities
in
the
human
body,
making
them
promising
tools
for
diagnosing
and
treating
diseases
minimally
invasively.
Despite
significant
advances,
development
of
with
desirable
locomotion
full
biocompatibility
under
harsh
physiological
conditions
remains
challenging,
which
put
forward
new
requirements
magnetic
robots’
design
material
synthesis.
Compared
that
are
synthesized
inorganic
materials,
natural
organisms
like
cells,
bacteria
or
other
microalgae
exhibit
ideal
properties
vivo
applications,
such
as
biocompatibility,
deformability,
auto-fluorescence,
self-propulsion,
well
easy
functional
therapeutics
engineering.
In
process,
these
can
provide
autonomous
propulsion
biological
fluids
external
fields,
while
retaining
their
functionalities
integrating
artificial
robots,
thus
aiding
targeted
therapeutic
delivery.
This
kind
robotics
is
named
bio-hybrid
robotics,
this
mini-review,
recent
progress
including
design,
engineering
potential
delivery
will
be
discussed.
Additionally,
historical
context
prominent
examples
introduced,
complexities,
pitfalls,
opportunities
associated
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 26, 2024
Abstract
The
combination
of
nanoparticles
and
tumor‐targeting
bacteria
for
cancer
immunotherapy
can
overcome
the
shortcomings
poor
nanoparticle
accumulation,
limited
penetration,
restricted
distribution.
However,
it
remains
a
great
challenge
hybrid
system
to
improve
therapeutic
efficacy
through
simultaneous
controllable
regulation
immune
cells
tumor
cells.
Herein,
platform
is
rationally
designed
achieve
cascade‐augmented
immunotherapy.
To
construct
hybrids,
photothermal
responsive
light
in
second
near‐infrared
(NIR‐II)
region
are
conjugated
onto
surface
engineered
pH‐responsive
Schiff
base
bonds.
Taking
advantage
hypoxia
targeting
deep
penetration
characteristics
bacteria,
hybrids
accumulate
at
sites.
Then
detach
from
realize
genetic
engineering
cells,
which
induces
cell
apoptosis
down‐regulate
expression
programmed
death
ligand
1
alleviate
immunosuppressive
microenvironment.
mild
heating
not
only
induce
tumor‐associated
antigen
release,
but
also
trigger
sustainable
cytokine
interleukin‐2.
Notably,
synergistic
antitumor
effect
achieved
between
process
p53
transfection
NIR‐II
light‐activated
bacteria.
This
work
proposes
facile
strategy
construction