Advances in local therapy for glioblastoma — taking the fight to the tumour

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(4), P. 221 - 236

Published: March 11, 2022

Language: Английский

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Non-invasive transcranial ultrasound stimulation for neuromodulation

Clinical Neurophysiology, Journal Year: 2021, Volume and Issue: 135, P. 51 - 73

Published: Dec. 31, 2021

Language: Английский

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Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(2), P. 116 - 134

Published: Jan. 5, 2023

Language: Английский

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Activatable Cancer Sono‐Immunotherapy using Semiconducting Polymer Nanobodies

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(28)

Published: May 7, 2022

Despite the great promises of sonodynamic therapy (SDT) in combination cancer therapy, its clinical applications are hindered by "always-on" pharmacological activities therapeutic agents and lack efficient sonosensitizers. Herein, development semiconducting polymers as sonosensitizers further sono-immunotherapeutic nanobodies (SPNAb ) for activatable sono-immunotherapy reported. Conjugation anti-CTLA-4 antibodies onto polymer nanoparticles through a 1 O2 -cleavable linker affords SPNAb with relatively low CTLA-4 binding affinity. Upon sono-irradiation, generates not only to elicit effect induce immunogenic cell death, but also release trigger situ checkpoint blockade. Such synergistic action mediated modulates tumoricidal function T-cell immunity promoting proliferation cytotoxic T lymphocytes depleting immunosuppressive regulatory cells, resulting effective tumor regression, metastasis inhibition, durable immunological memory, prevention relapse. Therefore, this study represents proof-of-concept strategy using precise spatiotemporal control over immunotherapy.

Language: Английский

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European Academy of Neurology/Movement Disorder Society‐European Section Guideline on the Treatment of Parkinson's Disease: I. Invasive Therapies

Movement Disorders, Journal Year: 2022, Volume and Issue: 37(7), P. 1360 - 1374

Published: July 1, 2022

ABSTRACT Background and Purpose This update of the treatment guidelines was commissioned by European Academy Neurology section Movement Disorder Society. Although these treatments are initiated usually in specialized centers, general neurologist should know therapies their place pathway. Methods Grading Recommendations Assessment, Development, Evaluation (GRADE) methodology used to assess spectrum approved interventions including deep brain stimulation (DBS) or lesioning with different techniques (radiofrequency thermocoagulation, radiosurgery, magnetic resonance imaging–guided focused ultrasound surgery [MRgFUS] following targets: subthalamic nucleus [STN], ventrolateral thalamus, pallidum internum [GPi]). Continuous delivery medication subcutaneously (apomorphine pump) through percutaneous ileostomy (intrajejunal levodopa/carbidopa pump [LCIG]) also included. Changes motor features, health‐related quality life (QoL), adverse effects, further outcome parameters were evaluated. based on high‐class evidence graded three gradations. If only lower class available but topic felt be high importance, clinical consensus guideline task force gathered. Results Two research questions have been answered eight recommendations five statements. Invasive reserved for specific patient groups situations mostly advanced stage Parkinson's disease (PD). Interventions may considered special profiles, which mentioned text. Therapy effects reported as change compared current medical treatment. STN‐DBS is best‐studied intervention PD fluctuations not satisfactorily controlled oral medications; it improves symptoms QoL, offered eligible patients. GPi‐DBS can offered. For early fluctuations, likely improve symptoms, QoL DBS people without fluctuations. LCIG an apomorphine sufficiently managed treatments. Unilateral MRgFUS STN distinctly unilateral within registries. Clinical reached statements: Radiosurgery gamma radiation cannot recommended, radiofrequency thermocoagulation treatment‐resistant thalamus resistant tremor recommended if other options available, medication‐resistant registries, recommended. Conclusions Evidence invasive heterogeneous. Only some a strong scientific basis. They differ profile tested groups. © 2022 The Authors. Disorders published Wiley Periodicals LLC behalf International Parkinson

Language: Английский

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Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: June 16, 2022

Abstract Checkpoint immunotherapies have been combined with other therapeutic modalities to increase patient response rate and improve outcome, which however exacerbates immune-related adverse events requires be carefully implemented in a narrowed window. Strategies for precisely controlled combinational cancer immunotherapy can tackle this issue but remain lacking. We herein report catalytical nano-immunocomplex precise persistent sono-metabolic checkpoint trimodal therapy, whose full activities are only triggered by sono-irradiation tumor microenvironment (TME). This comprises three FDA-approved components, wherein blockade inhibitor (anti-programmed death-ligand 1 antibody), immunometabolic reprogramming enzyme (adenosine deaminase, ADA), sonosensitizer (hematoporphyrin) covalently immobilized into one entity via acid-cleavable singlet oxygen-activatable linkers. Thus, the of initially silenced, under acidic TME, sonodynamic, blockade, remotely awakened. Due enzymatic conversion adenosine inosine ADA, reduce levels intratumoral inhibit A2A/A2B receptors-adenosinergic signaling, leading efficient activation immune effector cells inhibition suppressor vivo. study presents generic translatable nanoplatform towards precision immunotherapy.

Language: Английский

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Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions

Neuro-Oncology, Journal Year: 2022, Volume and Issue: 24(10), P. 1613 - 1646

Published: May 3, 2022

Brain metastases occur commonly in patients with advanced solid malignancies. Yet, less is known about brain than cancer-related entities of similar incidence. Advances oncologic care have heightened the importance intracranial management. Here, this consensus review supported by Society for Neuro-Oncology (SNO), we landscape particular attention to management approaches and ongoing efforts potential shape future paradigms care. Each coauthor carried an area expertise within field initially composed, edited, or reviewed their specific subsection interest. After each was accordingly written, multiple drafts manuscript were circulated entire list authors group discussion feedback. The hope that these guidelines will accelerate progress understanding metastases, highlight key areas need further exploration lead dedicated trials other research investigations designed advance field.

Language: Английский

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Human Studies of Transcranial Ultrasound neuromodulation: A systematic review of effectiveness and safety

Brain stimulation, Journal Year: 2022, Volume and Issue: 15(3), P. 737 - 746

Published: May 1, 2022

BackgroundTranscranial ultrasound stimulation (TUS) is gaining traction as a safe and non-invasive technique in human studies. There has been rapid increase TUS studies recent years, with more than half of to date published after 2020. This growth the relevant body literature necessitates comprehensive reviews update clinicians researchers.ObjectiveThe aim this work review an emphasis on devices, sonication parameters, outcome measures, results, adverse effects, well highlight future directions investigation.MethodsA systematic was conducted by searching Web Science PubMed databases January 12, 2022. Human were included.ResultsA total 35 identified using focused/unfocused devices. A 677 subjects belonging diverse cohorts (i.e., healthy, chronic pain, dementia, epilepsy, traumatic brain injury, depression) enrolled. The effects vary parameter-dependant fashion. Clinical, neurophysiological, radiological histological measures assessed. No severe reported any surveyed. Mild symptoms observed 3.4% (14/425) subjects, including headache, mood deterioration, scalp heating, cognitive problems, neck muscle twitches, anxiety, sleepiness pruritis.ConclusionsAlthough increasingly being used, still its early phases. can change short-term excitability connectivity, induce long-term plasticity, modulate behavior. New techniques should be used further elucidate underlying mechanisms identify application novel populations.

Language: Английский

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Ultrasound-mediated nano drug delivery for treating cancer: Fundamental physics to future directions

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 355, P. 552 - 578

Published: Feb. 15, 2023

Language: Английский

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CAR T Cell Therapy in Primary Brain Tumors: Current Investigations and the Future

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 21, 2022

Chimeric antigen receptor T cells (CAR cells) are engineered expressing a chimeric (CAR) against specific tumor (TA) that allows for the identification and elimination of cancer cells. The remarkable clinical effect seen with CAR cell therapies hematological malignancies have attracted interest in developing such solid tumors, including brain tumors. Glioblastoma (GBM) is most common primary adults associated poor prognosis due to its highly aggressive nature. Pediatric cancers similarly thus major cause pediatric cancer-related death. therapy represents promising avenue these malignancies. Several TAs, as EGFR/EGFRvIII, IL13Rα2, B7-H3, HER2, been targeted preclinical studies trials. Unfortunately, tumors showed limited efficacy TA heterogeneity, difficulty trafficking from blood sites, immunosuppressive microenvironment. Here, we review current approaches treating cancers, particular focus on cancers. We also describe novel technique focused ultrasound controlling activation achieve safer therapies. Finally, summarize development combinational strategies improve overcome historical limitations therapy.

Language: Английский

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