Effects of Low Intensity Focused Ultrasound Stimulation Combined With Functional Electrical Stimulation on Corticospinal Excitability and Upper Extremity Fine Motor Function DOI Creative Commons
Naaz Kapadia, Talyta Grippe, Tarun Arora

et al.

Brain and Behavior, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 1, 2025

Abstract Introduction Functional electrical stimulation (FES) is used to retrain motor function in neurological disorders but typically requires multiple sessions and shows limited benefits chronic cases. Low‐intensity transcranial focused ultrasound (TUS) a noninvasive brain (NIBS) method offering greater focality deeper penetration than current NIBS techniques. TUS delivered theta burst pattern (tbTUS) for 80 s produces neuroplastic changes with long‐term potentiation‐like effects lasting up 60 min healthy adults. Since tbTUS increases cortical excitability, combining it FES may enhance neuroplasticity. We hypothesized that would result increased corticospinal excitability compared alone lead improvement fine skills as assessed by Nine‐Hole Peg Test (NHPT) scores. Methods Fifteen participants underwent two study visits consisting of real or sham the left cortex immediately followed 30 first dorsal interosseous (FDI) opponens pollicis (OP) muscles training right hand. Motor‐evoked potentials (MEPs) were recorded from FDI, OP, abductor digiti minimi (ADM) at baseline (BL), after (T0), (T45), 15 (T65) (T80) post‐FES. NHPT was BL T80. Results Data 14 analyzed. It showed significant decrease MEP amplitudes FDI OP T45 following only tbTUS+FES return No seen scores either condition. Conclusion Real combined voluntary movement results immediate inhibition ∼20 post‐stimulation suggestive homeostatic metaplasticity. These findings highlight potential neuromodulatory intervention, warranting further exploration conditions therapeutic applications.

Language: Английский

Ultrasound Neuromodulation as a New Brain Therapy DOI Creative Commons
Roland Beisteiner, Mark Hallett, Andrés M. Lozano

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(14)

Published: March 24, 2023

Abstract Within the last decade, ultrasound has been “rediscovered” as a technique for brain therapies. Modern technologies allow focusing through human skull highly focal tissue ablation, clinical neuromodulatory stimulation, and targeted blood‐brain‐barrier opening. This article gives an overview on state‐of‐the‐art of most recent application: neuromodulation new therapy. Although research centers have existed decades, first treatment were not established until 2020, applications are spreading rapidly.

Language: Английский

Citations

42
Neuromodulation techniques – From non-invasive brain stimulation to deep brain stimulation DOI Creative Commons
Benjamin Davidson, Amitabh Bhattacharya, Can Sarica

et al.

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(3), P. e00330 - e00330

Published: Feb. 9, 2024

Over the past 30 years, field of neuromodulation has witnessed remarkable advancements. These developments encompass a spectrum techniques, both non-invasive and invasive, that possess ability to probe influence central nervous system. In many cases therapies have been adopted into standard care treatments. Transcranial magnetic stimulation (TMS), transcranial direct current (tDCS), ultrasound (TUS) are most common methods in use today. Deep brain (DBS), spinal cord (SCS), vagus nerve (VNS), leading surgical for neuromodulation. Ongoing active clinical trials using uncovering novel applications paradigms these interventions.

Language: Английский

Citations

32
Low-intensity focused ultrasound to the human dorsal anterior cingulate attenuates acute pain perception and autonomic responses. DOI Creative Commons
Andrew Strohman, Brighton Payne, Alexander In

et al.

Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. e1011232023 - e1011232023

Published: Jan. 5, 2024

The dorsal anterior cingulate cortex (dACC) is a critical brain area for pain and autonomic processing, making it promising non-invasive therapeutic target. We leverage the high spatial resolution deep focal lengths of low-intensity focused ultrasound (LIFU) to non-invasively modulate dACC effects on behavioral cardiac responses using transient heat stimuli. N = 16 healthy human volunteers (6M/10F) received contact during either LIFU or Sham stimulation. Continuous electroencephalogram (EEG), electrocardiogram (ECG), electrodermal response (EDR) were recorded. Outcome measures included ratings, heart-rate variability, EDR response, blood pressure, amplitude heat-evoked potential (CHEP). reduced ratings by 1.09 ± 0.20 points relative Sham. increased heart rate variability indexed standard deviation normal sinus beats (SDNN), low frequency (LF) power, low-frequency/high-frequency (LF/HF) ratio. There no pressure EDR. resulted in 38.1% reduction P2 CHEP amplitude. Results demonstrate reduces alters acute This has implications causal understanding processing future options relief modulation homeostatic signals. Significance Statement New lines inquiry signals like (HRV) are aberrant chronic mental health disorders, which may contribute their underlying etiology. key center with direct influences function, but its depth precludes access without invasive surgery. For first time humans, we can selectively reduce perception, responses, work further establishes role clinical applications neuropsychological populations.

Language: Английский

Citations

18
Noninvasive modulation of essential tremor with focused ultrasonic waves DOI Creative Commons
Thomas Riis, Adam J. Losser, Panagiotis Kassavetis

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(1), P. 016033 - 016033

Published: Feb. 1, 2024

Abstract Objective : Transcranial focused low-intensity ultrasound has the potential to noninvasively modulate confined regions deep inside human brain, which could provide a new tool for causal interrogation of circuit function in humans. However, it been unclear whether approach is potent enough behavior. Approach To test this, we applied brain thalamic target, ventral intermediate nucleus, three patients with essential tremor. Main results Brief, 15 s stimulations target at 10% duty cycle ultrasound, repeated less than 30 times over period 90 min, nearly abolished tremor (98% and 97% amplitude reduction) 2 out 3 patients. The effect was observed within seconds stimulation onset increased exposure time. gradually vanished following stimulation, suggesting that safe no harmful long-term consequences detected. Significance This result demonstrates can robustly humans notable effects on overt motor

Language: Английский

Citations

16
A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium DOI Creative Commons

Keith R. Murphy,

Tulika Nandi, Benjamin R. Kop

et al.

Clinical Neurophysiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

2
Accelerated Transcranial Ultrasound Neuromodulation in Parkinson's Disease: A Pilot Study DOI Creative Commons
Nardin Samuel,

Mandy Yi Rong Ding,

Can Sarica

et al.

Movement Disorders, Journal Year: 2023, Volume and Issue: 38(12), P. 2209 - 2216

Published: Oct. 9, 2023

Abstract Objective Low‐intensity transcranial focused ultrasound (TUS) is a novel method for neuromodulation. We aimed to study the feasibility of stimulating bilateral primary motor cortices (M1) with accelerated theta‐burst TUS (a‐tbTUS) on neurophysiologic and clinical outcomes in Parkinson's disease (PD). Methods Patients were randomly assigned receive active or sham a‐tbTUS first visit alternate condition second visit, at least 10 days apart. was administered three consecutive sonications 30‐minute intervals. used an protocol produce additive effect stimulation. studied OFF‐medication state. Transcranial magnetic stimulation (TMS)‐elicited motor‐evoked potentials (MEPs) assess cortical excitability before after TUS. Clinical administration assessed using Movement Disorder Society Unified Disease Rating Scale (MDS‐UPDRS)‐III. Results A total 20 visits conducted PD patients. Compared baseline, TMS‐elicited MEP amplitudes significantly increased following but not sonication ( P = 0.0057). also higher than 0.0064). There no statistically significant changes MDS‐UPDRS‐III scores a‐tbTUS. Conclusions increases cortex feasible non‐invasive neuromodulation strategy PD. Future studies should determine optimal dosing parameters durability © 2023 The Authors. Disorders published by Wiley Periodicals LLC behalf International Parkinson Society.

Language: Английский

Citations

32
Mechanisms of theta burst transcranial ultrasound induced plasticity in the human motor cortex DOI Creative Commons
Yazan Shamli Oghli, Talyta Grippe, Tarun Arora

et al.

Brain stimulation, Journal Year: 2023, Volume and Issue: 16(4), P. 1135 - 1143

Published: July 1, 2023

Transcranial ultrasound stimulation (TUS) is a novel non-invasive brain technique with high depth penetrance and spatial resolution. Theta-burst TUS (tbTUS) plasticity-inducing protocol which increases motor cortical excitability for up to 30 min following 80s of sonication. While this may have therapeutic potential the treatment psychiatric neurological disorders, mechanisms action remain unclear.We conducted first pharmacological study examine in human primary cortex. By administering brain-active drugs known action, we aimed elucidate tbTUS.Fourteen healthy subjects participated within-subjects randomized, double-blind, cross-over five visits. At each visit, one four (carbamazepine - Na+ channel blocker, nimodipine L-type Ca2+ lorazepam positive allosteric modulator gamma-aminobutyric acid (GABA) type A receptor, dextromethorphan N-methyl-d-aspartate receptor antagonist) or placebo was administered random order, followed by tbTUS.The plasticity effects tbTUS on cortex measured motor-evoked amplitudes elicited transcranial magnetic were reduced all compared placebo.tbTUS induce NMDA-dependent synaptic since are blocked increased GABAA activities voltage-gated channels blockers. These results consistent hypotheses that induced long-term potentiation-like involves activation mechanosensitive channels. Alternatively, non-specific pharmacologically changes excitatory/inhibitory balance might interfered tbTUS.

Language: Английский

Citations

29
Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention DOI Creative Commons
Joshua Kosnoff, Kai Yu, Chang Liu

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: June 11, 2024

Abstract A brain-computer interface (BCI) enables users to control devices with their minds. Despite advancements, non-invasive BCIs still exhibit high error rates, prompting investigation into the potential reduction through concurrent targeted neuromodulation. Transcranial focused ultrasound (tFUS) is an emerging neuromodulation technology spatiotemporal precision. This study examines whether tFUS can improve BCI outcomes, and explores underlying mechanism of action using high-density electroencephalography (EEG) source imaging (ESI). As a result, V5-targeted significantly reduced in speller task. Source analyses revealed increase theta alpha activities condition at both V5 downstream dorsal visual processing pathway. Correlation analysis indicated that connection within pathway was preserved during stimulation, while ventral weakened. These findings suggest enhances feature-based attention motion.

Language: Английский

Citations

12
A systematic review of preclinical and clinical transcranial ultrasound neuromodulation and opportunities for functional connectomics DOI Creative Commons
Carly Pellow, Samuel Pichardo, G. Bruce Pike

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(4), P. 734 - 751

Published: June 15, 2024

Low-intensity transcranial ultrasound has surged forward as a non-invasive and disruptive tool for neuromodulation with applications in basic neuroscience research the treatment of neurological psychiatric conditions. To provide comprehensive overview update preclinical clinical low intensity emphasize emerging role functional brain mapping to guide, better understand, predict responses. A systematic review was conducted by searching Web Science Scopus databases studies on neuromodulation, both humans animals. 187 relevant were identified reviewed, including 116 71 reports subjects belonging diverse cohorts. Milestones are described within an broader landscape. General neural readouts outcome measures discussed, potential confounds noted, use magnetic resonance imaging is highlighted. Ultrasound emerged powerful study treat range conditions its combination various significantly advanced this platform. In particular, yielded exciting inferences into advance our understanding function, neuromodulatory mechanisms, ultimately outcomes. It anticipated that these trials first many; focused ultrasound, particularly imaging, enhance spectrum

Language: Английский

Citations

10
Thalamic transcranial ultrasound stimulation in treatment resistant depression DOI Creative Commons
Joline M. Fan,

Kai Woodworth,

Keith R. Murphy

et al.

Brain stimulation, Journal Year: 2024, Volume and Issue: 17(5), P. 1001 - 1004

Published: Aug. 23, 2024

Language: Английский

Citations

10