Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(1), P. 120 - 120
Published: Jan. 17, 2024
Multiple
sclerosis
is
an
important
neurological
disease
affecting
millions
of
young
patients
globally.
It
encouraging
that
more
than
ten
disease-modifying
drugs
became
available
for
use
in
the
past
two
decades.
These
therapies
(DMTs)
have
different
levels
efficacy,
routes
administration,
adverse
effect
profiles
and
concerns
pregnancy.
Much
knowledge
caution
are
needed
their
appropriate
MS
who
heterogeneous
clinical
features
severity,
lesion
load
on
magnetic
resonance
imaging
response
to
DMT.
We
aim
updated
review
concept
personalization
DMT
relapsing
patients.
Shared
decision
making
with
consideration
preference
expectation
understand
potential
efficacy/benefits
risks
advocated.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(9), P. 5023 - 5023
Published: April 30, 2022
Positron
emission
tomography
(PET)
uses
radioactive
tracers
and
enables
the
functional
imaging
of
several
metabolic
processes,
blood
flow
measurements,
regional
chemical
composition,
and/or
absorption.
Depending
on
targeted
processes
within
living
organism,
different
are
used
for
various
medical
conditions,
such
as
cancer,
particular
brain
pathologies,
cardiac
events,
bone
lesions,
where
most
commonly
radiolabeled
with
18F
(e.g.,
[
Genome Medicine,
Journal Year:
2023,
Volume and Issue:
15(1)
Published: Jan. 26, 2023
Abstract
Alzheimer’s
disease
(AD)
is
a
genetically
complex
and
heterogeneous
disorder
with
multifaceted
neuropathological
features,
including
β-amyloid
plaques,
neurofibrillary
tangles,
neuroinflammation.
Over
the
past
decade,
emerging
evidence
has
implicated
both
beneficial
pathological
roles
for
innate
immune
genes
cells,
peripheral
cells
such
as
T
which
can
infiltrate
brain
either
ameliorate
or
exacerbate
AD
neuropathogenesis.
These
findings
support
neuroimmune
axis
of
AD,
in
interplay
adaptive
systems
inside
outside
critically
impacts
etiology
pathogenesis
AD.
In
this
review,
we
discuss
complexities
neuropathology
at
levels
genetics
cellular
physiology,
highlighting
signaling
pathways
associated
risk
interactions
among
brain.
We
emphasize
role
mechanisms
by
monocytes,
influence
neuropathology,
microglial
clearance
amyloid-β
peptide,
key
component
plaque
cores,
pro-inflammatory
cytotoxic
activity
microglia,
astrogliosis,
their
vasculature.
Finally,
review
challenges
outlook
establishing
immune-based
therapies
treating
preventing
Frontiers in Neurology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 3, 2022
Multiple
sclerosis
(MS)
is
an
autoimmune
disease
affecting
the
central
nervous
system
that
causes
significant
disability
and
healthcare
burden.
The
treatment
of
MS
has
evolved
over
past
three
decades
with
development
new,
high
efficacy
modifying
therapies
targeting
various
mechanisms
including
immune
modulation,
cell
suppression
or
depletion
enhanced
sequestration.
Emerging
include
CNS-penetrant
Bruton's
tyrosine
kinase
inhibitors
autologous
hematopoietic
stem
transplantation
as
well
aimed
at
remyelination
neuroprotection.
Therapy
for
progressive
been
more
challenging
limited
current
approved
agents
inactive
older
patients
MS.
aim
this
review
to
provide
a
broad
overview
therapeutic
landscape
Journal of Clinical Medicine,
Journal Year:
2023,
Volume and Issue:
12(5), P. 1709 - 1709
Published: Feb. 21, 2023
Neurological
disorders
are
the
leading
cause
of
physical
and
cognitive
disability
across
globe,
currently
affecting
approximately
15%
worldwide
population
[...].
