Advances in Traditional Medicine,
Journal Year:
2024,
Volume and Issue:
24(3), P. 813 - 822
Published: Jan. 17, 2024
Abstract
Chemotherapy-induced
cognitive
impairment
(CICI)
is
an
of
memory,
learning
power,
concentration,
reasoning,
executive
function,
attention,
and
visuospatial
during
after
chemotherapy
exposures.
No
proven
safe
effective
therapeutic
regimen
are
available
to
improve
function
in
CICI
patients.
To
evaluate
the
safety
effectiveness
curcumin
extract
This
study
was
a
double-blind
randomized
controlled
trial
clinical
patients
with
cervical
carcinoma
who
underwent
carboplatin-paclitaxel
from
March
October
2021
at
single
center
hospital.
Subjects
divided
into
two
groups
that
received
placebo
caplets
by
dose
escalation
method
240
400
mg
intermittently
(14
days
on
7
off)
between
cycles.
Cognitive
evaluated
pre-
post-therapy
using
AFI
questionnaire,
Stroop
test,
MoCA-Ina.
A
total
78
subjects
were
equally
treatment
control
groups.
The
percentage
drop-out,
mortality,
adverse
drug
response
relatively
comparable
each
arm.
group
receiving
experienced
clinically
statistically
significant
improvements
based
test
(∆
median
8.57
vs.
2.46;
Z
−
4.503
1.762;
p
<
0.0001
0.078)
MoCA-
Ina
mean
1.53
0.72;
2.99
2.05;
0.003
0.04)
versus
between-group
between-subject
analyses,
respectively.
Administration
intermittent
proved
be
able
significant.
Breast Cancer Research and Treatment,
Journal Year:
2024,
Volume and Issue:
205(1), P. 75 - 86
Published: Jan. 29, 2024
Abstract
Purpose
Cancer-related
cognitive
impairment
(CRCI)
following
chemotherapy
is
commonly
reported
in
breast
cancer
survivors,
even
years
after
treatment.
Data
from
preclinical
studies
suggest
that
exercise
during
may
prevent
or
diminish
problems;
however,
clinical
data
are
scarce.
Methods
This
a
pragmatic
follow-up
study
of
two
original
randomized
trials,
which
compares
patients
to
non-exercise
controls
8.5
post-treatment.
Cognitive
outcomes
include
an
online
neuropsychological
test
battery
and
self-reported
complaints.
performance
was
compared
normative
expressed
as
age-adjusted
z-scores.
Results
A
total
143
participated
the
testing.
Overall,
mildly
impaired
on
some,
but
not
all,
domains,
with
no
significant
differences
between
groups.
Clinically
relevant
present
25%
40%
all
participants,
regardless
group.
We
observed
statistically
effect
exercise,
being
physically
active
chemotherapy,
long-term
cognition,
except
for
task
reaction
time,
favored
control
group
(β
=
-2.04,
95%
confidence
interval:
-38.48;
-2.38).
association
higher
physical
activity
levels
at
better
outcomes.
Conclusion
In
this
study,
exercising
overall
more
adjuvant
associated
tested
functioning,
average,
Future
prospective
needed
document
complex
relationship
CRCI
survivors.
Cancer Research,
Journal Year:
2024,
Volume and Issue:
84(13), P. 2041 - 2042
Published: April 24, 2024
Many
patients
with
cancer
are
at
risk
of
developing
cognitive
symptoms
that
often
become
evident
during
or
after
cancer-directed
therapy
and
may
have
difficulties
attention,
concentration,
multitasking,
executive
function,
memory.
Despite
recent
advances
in
identifying
potential
molecular
cellular
mechanisms
underlying
chemotherapy-related
impairment,
there
is
generally
a
lack
effective
treatment
strategies,
the
development
novel
therapeutic
interventions
represents
major
unmet
medical
need
clinical
practice.
A
study
by
Kim
colleagues
suggests
multisensory
40-Hz
gamma
entrainment
using
sensory
stimuli
combined
visual
auditory
associated
powerful
neuroprotective
effects
mouse
models
cisplatin-
methotrexate-induced
"chemobrain."
Although
has
some
limitations
successful
animal
failed
to
translate
into
practice,
this
noninvasive
modality
shown
promise
preserving
brain
structure
function
could
be
tested
who
decline.
JNCI Journal of the National Cancer Institute,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Cancer-related
cognitive
impairment
is
a
broad
term
encompassing
subtle
problems
to
more
severe
impairment.
The
severity
of
this
influenced
by
host,
disease,
and
treatment
factors,
the
affects
patients
before,
during,
following
cancer
treatment.
National
Cancer
Institute
(NCI)
Symptom
Management
Health-Related
Quality
Life
Steering
Committee
(SxQoL
SC)
convened
clinical
trial
planning
meeting
review
state
science
on
cancer-related
develop
phase
II/III
intervention
trials
aimed
at
improving
function
in
survivors
with
non–central
nervous
system
disease
longitudinal
studies
understand
trajectory
contributing
factors.
Participants
included
experts
field
impairment,
members
SxQoL
SC,
patient
advocates,
representatives
from
all
7
NCI
Community
Oncology
Research
Program
research
bases,
NCI.
Presentations
focused
topics:
measurement,
lessons
learned
pediatric
geriatric
oncology,
biomarker
mechanism
endpoints,
study
designs,
pharmacological
behavioral
trials.
Panel
discussions
provided
guidance
priority
assessments,
considerations
for
remote
inclusion
relevant
biomarkers,
strategies
ensuring
criteria.
Three
working
groups
(longitudinal
as
well
trials)
1
year
discuss
report
top
priorities
design
studies.
concluded
that
sufficient
data
exist
advance
using
selected
interventions
setting,
recommendations
herein.
Psycho-Oncology,
Journal Year:
2023,
Volume and Issue:
32(8), P. 1298 - 1305
Published: June 28, 2023
Abstract
Objective
Subjective
reports
of
cancer‐related
cognitive
impairment
often
far
exceed
that
documented
using
in‐person
neuropsychological
assessment.
This
study
evaluated
whether
subjective
cognition
was
associated
with
real‐time
objective
performance
in
daily
life
versus
on
an
battery,
as
well
fatigue
and
depressed
mood.
Methods
Participants
were
47
women
(M
age
=
53.3
years)
who
completed
adjuvant
treatment
for
early‐stage
breast
cancer
6–36
months
previously.
During
assessment,
participants
a
battery
questionnaires
cognition,
fatigue,
Over
14
days,
responded
to
up
5
prompts
assessed
processing
speed
memory
self‐reported
ratings
mood
fatigue.
In
the
evenings,
rated
their
day
reported
lapses
(e.g.,
forgetting
word).
Results
worse
mood,
but
did
not
exhibit
poorer
performance.
Women
more
demonstrate
cognition.
Finally,
at
end
demonstrated
better
(
p
0.001),
visuospatial
skills
's
≤
0.02).
Conclusion
consistently
Specific
related
suggests
incorporating
may
help
clinicians
identify
those
objectively
measured
impairment.
Advances in Traditional Medicine,
Journal Year:
2024,
Volume and Issue:
24(3), P. 813 - 822
Published: Jan. 17, 2024
Abstract
Chemotherapy-induced
cognitive
impairment
(CICI)
is
an
of
memory,
learning
power,
concentration,
reasoning,
executive
function,
attention,
and
visuospatial
during
after
chemotherapy
exposures.
No
proven
safe
effective
therapeutic
regimen
are
available
to
improve
function
in
CICI
patients.
To
evaluate
the
safety
effectiveness
curcumin
extract
This
study
was
a
double-blind
randomized
controlled
trial
clinical
patients
with
cervical
carcinoma
who
underwent
carboplatin-paclitaxel
from
March
October
2021
at
single
center
hospital.
Subjects
divided
into
two
groups
that
received
placebo
caplets
by
dose
escalation
method
240
400
mg
intermittently
(14
days
on
7
off)
between
cycles.
Cognitive
evaluated
pre-
post-therapy
using
AFI
questionnaire,
Stroop
test,
MoCA-Ina.
A
total
78
subjects
were
equally
treatment
control
groups.
The
percentage
drop-out,
mortality,
adverse
drug
response
relatively
comparable
each
arm.
group
receiving
experienced
clinically
statistically
significant
improvements
based
test
(∆
median
8.57
vs.
2.46;
Z
−
4.503
1.762;
p
<
0.0001
0.078)
MoCA-
Ina
mean
1.53
0.72;
2.99
2.05;
0.003
0.04)
versus
between-group
between-subject
analyses,
respectively.
Administration
intermittent
proved
be
able
significant.
