A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress DOI Creative Commons
Shuancheng Ren,

Cai Zhang,

Faguo Yue

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 28, 2024

Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal associated impaired behavioral performance. Although the neural circuitries promoting in stress conditions have been extensively identified, less known about circuit mechanisms constraining prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation GAD2-positive GABAergic neurons midbrain dorsal raphe nucleus (DRN GAD2 ) decreased wakefulness, while inhibition ablation these produced an increase along hyperactivity. Surprisingly, DRN were paradoxically wakefulness-active and further activated by stress. Bidirectional manipulations revealed constrained arousal level mouse model Circuit-specific investigations demonstrated via wakefulness-promoting paraventricular thalamus. Therefore, present study identified wakefulness-constraining role conditions.

Language: Английский

Terahertz Photons Improve Cognitive Functions in Posttraumatic Stress Disorder DOI Creative Commons
Yun Yu, Kaijie Wu,

Yang Xiao

et al.

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Posttraumatic stress disorder (PTSD) is a serious psychosis leading to cognitive impairment. To restore functions for patients, the main treatments are based on medication or rehabilitation training but with limited effectiveness and strong side effects. Here, we demonstrate new treatment approach PTSD by using terahertz (THz) photons stimulating hippocampal CA3 subregion. We verified that this method can nonthermally function in rats vivo. After THz photon irradiation, rats’ recognitive index improved about 10% novel object recognition test, accuracy 100% shuttler box numbers identify target was 5 times lower Barnes maze rate of staying arm increased approximately 40% Y-maze test. Further experimental studies found (34.5 THz) irradiation could improve expression NR2B (increased nearly 40%) phosphorylated 50%). In addition, molecular dynamics simulations showed at frequency 34.5 mainly absorbed pocket glutamate receptors rather than molecules. Moreover, binding between molecules photons. This study offers nondrug, nonthermal regulate excitatory neurotransmitter (glutamate) NR2B. By increasing synaptic plasticity, it effectively improves animals PTSD, providing promising strategy NR2B-related disorders.

Language: Английский

Citations

52
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder DOI
Caroline M. Nievergelt, Adam X. Maihofer, Elizabeth G. Atkinson

et al.

Nature Genetics, Journal Year: 2024, Volume and Issue: 56(5), P. 792 - 808

Published: April 18, 2024

Language: Английский

Citations

50
Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis DOI

Yuan Yao,

Dan Guo,

Tangsheng Lu

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 335, P. 115886 - 115886

Published: March 28, 2024

Language: Английский

Citations

25
The Psychedelic Future of Post-Traumatic Stress Disorder Treatment DOI

Tamar Glatman Zaretsky,

Kathleen M. Jagodnik,

Robert Barsic

et al.

Current Neuropharmacology, Journal Year: 2024, Volume and Issue: 22(4), P. 636 - 735

Published: Jan. 5, 2024

Post-traumatic stress disorder (PTSD) is a mental health condition that can occur following exposure to traumatic experience. An estimated 12 million U.S. adults are presently affected by this disorder. Current treatments include psychological therapies (e.g., exposure-based interventions) and pharmacological selective serotonin reuptake inhibitors (SSRIs)). However, significant proportion of patients receiving standard-of-care for PTSD remain symptomatic, new approaches other trauma-related conditions greatly needed. Psychedelic compounds alter cognition, perception, mood currently being examined their efficacy in treating despite current status as Drug Enforcement Administration (DEA)- scheduled substances. Initial clinical trials have demonstrated the potential value psychedelicassisted therapy treat psychiatric disorders. In comprehensive review, we summarize state science care, including shortcomings. We review studies psychedelic interventions PTSD, disorders, common comorbidities. The classic psychedelics psilocybin, lysergic acid diethylamide (LSD), N,N-dimethyltryptamine (DMT) DMT-containing ayahuasca, well entactogen 3,4-methylenedioxymethamphetamine (MDMA) dissociative anesthetic ketamine, reviewed. For each drug, present history use, somatic effects, pharmacology, safety profile. rationale proposed mechanisms use traumarelated disorders discussed. This concludes with an in-depth consideration future directions applications maximize therapeutic benefit minimize risk individuals communities impacted conditions.

Language: Английский

Citations

16
Post‐traumatic stress disorder: evolving conceptualization and evidence, and future research directions DOI Open Access

C. R. Brewin,

Lukoye Atwoli, Jonathan I. Bisson

et al.

World Psychiatry, Journal Year: 2025, Volume and Issue: 24(1), P. 52 - 80

Published: Jan. 15, 2025

The understanding of responses to traumatic events has been greatly influenced by the introduction diagnosis post‐traumatic stress disorder (PTSD). In this paper we review initial versions diagnostic criteria for condition and associated epidemiological findings, including sociocultural differences. We consider evidence reactions occurring in multiple contexts not previously defined as traumatic, implications that these observations have diagnosis. More recent developments such DSM‐5 dissociative subtype ICD‐11 complex PTSD are reviewed, adding there several distinct phenotypes. describe psychological foundations PTSD, involving disturbances memory well identity. A broader focus on identity may be able accommodate group communal influences experience trauma impact resource loss. then summarize current concerning biological with a particular genetic neuroimaging studies. Whereas progress prevention disappointing, is now an extensive supporting efficacy variety treatments established trauma‐focused interventions – cognitive behavior therapy (TF‐CBT) eye movement desensitization reprocessing (EMDR) non‐trauma‐focused therapies, which also include some emerging identity‐based approaches present‐centered compassion‐focused therapies. Additionally, promising neither nor pharmacological, or combine pharmacological approach, 3,4‐methylenedioxymethamphetamine (MDMA)‐assisted psychotherapy. advances priority areas adapting resource‐limited settings across cultural contexts, community‐based approaches. conclude identifying future directions work mental health.

Language: Английский

Citations

9
Alleviating anxiety and taming trauma: Novel pharmacotherapeutics for anxiety disorders and posttraumatic stress disorder DOI Creative Commons
Nicolas Singewald, Simone B. Sartori, Andreas Reif

et al.

Neuropharmacology, Journal Year: 2023, Volume and Issue: 226, P. 109418 - 109418

Published: Jan. 6, 2023

Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly prevalent increasing cause of morbidity worldwide. Current therapeutic approaches, including medication, effective in alleviating symptoms posttraumatic disorder (PTSD), at least some individuals, but have unwanted side-effects do not resolve underlying pathophysiology. After period stagnation, there is renewed enthusiasm from public, academic commercial parties designing developing drug treatments for these disorders. Here, we aim to provide snapshot the current state this field that written neuropharmacologists, also practicing clinicians interested lay-reader. introducing currently available treatments, summarize recent/ongoing clinical assessment novel medicines PTSD, grouped according primary neurochemical targets their potential produce acute and/or enduring effects. The evaluation putative targeting monoamine (including psychedelics), GABA, glutamate, cannabinoid, cholinergic neuropeptide systems, amongst others, discussed. We emphasize importance clinically assessing new medications based on firm understanding neurobiology stemming rapid advances being made neuroscience. This includes harnessing neuroplasticity bring about lasting beneficial changes brain rather than – as many transient attenuation symptoms, exemplified by combining psychotropic/cognitive enhancing drugs psychotherapeutic approaches. conclude noting other emerging trends promising phase development.

Language: Английский

Citations

37
Thalamic nucleus reuniens coordinates prefrontal-hippocampal synchrony to suppress extinguished fear DOI Creative Commons
Michael S. Totty, Tuğçe Tuna, Karthik R. Ramanathan

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 17, 2023

Traumatic events result in vivid and enduring fear memories. Suppressing the retrieval of these memories is central to behavioral therapies for pathological fear. The medial prefrontal cortex (mPFC) hippocampus (HPC) have been implicated suppression, but how mPFC-HPC activity coordinated during extinction unclear. Here we show that after training, coherent theta oscillations (6-9 Hz) HPC mPFC are correlated with suppression conditioned freezing male female rats. Inactivation nucleus reuniens (RE), a thalamic hub interconnecting HPC, reduces extinction-related Fos expression both dampens coherence, impairs retrieval. Conversely, theta-paced optogenetic stimulation RE augments relapse extinguished Collectively, results demonstrate role coordinating interactions suppress extinction.

Language: Английский

Citations

31
Lifetime posttraumatic stress disorder as a predictor of mortality: a systematic review and meta-analysis DOI Creative Commons
Dinuli Nilaweera, Aung Zaw Zaw Phyo, Achamyeleh Birhanu Teshale

et al.

BMC Psychiatry, Journal Year: 2023, Volume and Issue: 23(1)

Published: April 10, 2023

Posttraumatic Stress Disorder (PTSD) could potentially increase the risk of mortality, and there is a need for meta-analysis to quantify this association. This study aims determine extent which PTSD predictor mortality.

Language: Английский

Citations

24
The psychiatric dysfunctions associated to the labor estrés in professionals of the education DOI Creative Commons
María de las Nieves Veloz Montano

Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria, Journal Year: 2023, Volume and Issue: 3, P. 60 - 60

Published: Sept. 24, 2023

Stress caused by working conditions or environments continues to be a scourge that affects workers worldwide and can affect physical mental health, even favoring the emergence of somatic, endocrine, psychiatric diseases. In education, especially teachers who work directly with students school maladjustments, learning disorders, which require greater effort in teaching-learning process, long hours constant demands are exposed permanent sources stress at work. The paper describes psychological problems educational sector offers preventive measures avoid it.

Language: Английский

Citations

23
Acute Stress Disorder among 2022 Ukrainian war refugees: a cross-sectional study DOI Creative Commons
Piotr Kordel, Marcin Rządeczka, Marta Studenna-Skrukwa

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: March 14, 2024

Introduction Fleeing from war can be terrifying and result in Acute Stress Disorder (ASD), a mental health condition that occur the first month after traumatic event. The study aimed to identify prevalence of ASD among Ukrainian refugees its risk factors create profile most vulnerable refugees. Methods This cross-sectional 637 war-displaced persons 2022 used Scale. Results participants was high (93.5%). Several increasing developing sample were identified, e.g., witnessing Russian attacks (OR 2.92, 95% CI 1.26–6.78), insufficient financial resources 3.56, 1.61–7.91), feeling loneliness host country 3.07, 1.58–8.69). Pre-existing depression death close person, others, found significantly ( p < 0.05) exacerbate symptoms. At same time, neither age, distance traveled, time spent on fleeing country, nor type companionship during refuge (escaping alone, with children, pets or older adults) correlate severity Conclusion shows extreme levels trauma displaced persons. Knowledge regarding vulnerabilities present conflict may facilitate prompt adequate psychological help. Since an antecedent PTSD several autoimmune disorders, these results also serve as predictor future challenges for society.

Language: Английский

Citations

9