Effect of Lacticaseibacillus paracasei strain Shirota supplementation on clinical responses and gut microbiome in Parkinson's disease

Food & Function, Journal Year: 2023, Volume and Issue: 14(15), P. 6828 - 6839

Published: Jan. 1, 2023

Parkinson's disease (PD) is a common neurodegenerative characterized by motor issues and range of non-motor symptoms. Microbial therapy may be useful approach for the treatment PD. However, comprehensive analyses impact probiotic supplementation on symptoms are still lacking mechanisms whereby works remain unclear. This study investigated Lacticaseibacillus paracasei strain Shirota (LcS) clinical responses, gut microbiota faecal metabolites in PD patients. Patients (n = 128) were randomised to receive either probiotics (LcS-fermented milk, containing 1 × 1010 living LcS cells) or placebo 12 weeks. All participants examined basic features recorded using questionnaires. Fecal blood samples collected at baseline after weeks further omics analysis. We found that intervention significantly alleviated patients' constipation-related no significant shifts composition metabolites. Several taxa differentially abundant between groups, especially with regard intake, which increased abundance genus group compared those group. The concentration L-tyrosine was decreased plasma Our demonstrated although did not induce major changes global microbiome, had favorable effects managing constipation other registered Chinese Clinical Trial Registry: ChiCTR1800016795.

Language: Английский

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Beyond the Microbiota: Understanding the Role of the Enteric Nervous System in Parkinson’s Disease from Mice to Human

Biomedicines, Journal Year: 2023, Volume and Issue: 11(6), P. 1560 - 1560

Published: May 27, 2023

The enteric nervous system (ENS) is a nerve network composed of neurons and glial cells that regulates the motor secretory functions gastrointestinal (GI) tract. There abundant evidence mutual communication between brain GI Dysfunction these connections appears to be involved in pathophysiology Parkinson's disease (PD). Alterations ENS have been shown occur very early PD, even before central (CNS) involvement. Post-mortem studies PD patients aggregation α-synuclein (αS) specific subtypes ENS. Subsequently, αS spreads retrogradely CNS through preganglionic vagal fibers this nerve's dorsal nucleus (DMV) other structures. Here, we highlight role pathogenesis based on observed animal models using translational perspective. While acknowledging putative microbiome gut-brain axis (GBA), review provides comprehensive view not only as "second brain", but also window into "first potentially crucial element search for new therapeutic approaches can delay cure disease.

Language: Английский

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Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson’s disease

npj Parkinson s Disease, Journal Year: 2023, Volume and Issue: 9(1)

Published: July 13, 2023

The biological basis of the neurodegenerative movement disorder, Parkinson's disease (PD), is still unclear despite it being 'discovered' over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying theories as to its pathobiology. aim this article was explore some these different by summarizing viewpoints laboratory and clinician scientists field, disease. To achieve aim, we posed question thirteen "PD experts" from six continents (for global representation) collated their personal opinions into article. views were varied, ranging toxin exposure a trigger, LRRK2 potential root cause, toxic alpha-synuclein most important etiological contributor. Notably, also growing recognition that definition single should be reconsidered, perhaps each with own unique pathobiology treatment regimen.

Language: Английский

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Gut microbiota dysbiosis and Huntington's disease: Exploring the gut-brain axis and novel microbiota-based interventions

Life Sciences, Journal Year: 2023, Volume and Issue: 328, P. 121882 - 121882

Published: June 24, 2023

Language: Английский

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Single‐particle analysis of circulating bacterial extracellular vesicles reveals their biogenesis, changes in blood and links to intestinal barrier

Journal of Extracellular Vesicles, Journal Year: 2023, Volume and Issue: 12(12)

Published: Dec. 1, 2023

Bacterial extracellular vesicles (BEVs) are nano-size particles secreted by bacteria that carry various bioactive components. These thought to provide a new window into the mechanisms which affect their hosts, but fundamental proprieties within human remain poorly understood. Here, we developed single-vesicle analytical platform enabled BEV detection in complex biological samples of host. Using this platform, found presence BEVs host circulation and they were mainly derived from gut microbes. We showed levels circulating humans significantly increased with aging due an age-related increase intestinal permeability. Significantly different blood also patients colorectal cancer colitis. Together, our study provides insights biology reveals potential as class biomarkers.

Language: Английский

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