Published: Jan. 1, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 16, 2024
Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management
Language: Английский
Citations
231
FEBS Journal, Journal Year: 2024, Volume and Issue: unknown
Published: March 1, 2024
Huntington's disease (HD) is a currently incurable neurogenerative disorder and typically characterized by progressive movement (including chorea), cognitive deficits (culminating in dementia), psychiatric abnormalities (the most common of which depression), peripheral symptoms gastrointestinal dysfunction). There are no approved disease‐modifying therapies available for HD, with death usually occurring approximately 10–25 years after onset, but some hold promising potential. HD subjects often burdened chronic diarrhea, constipation, esophageal gastric inflammation, susceptibility to diabetes. Our understanding the microbiota–gut–brain axis its infancy growing evidence from preclinical clinical studies suggests role gut microbial population imbalance (gut dysbiosis) pathophysiology. The brain can communicate through enteric nervous system, immune vagus nerve, microbiota‐derived‐metabolites including short‐chain fatty acids, bile branched‐chain amino acids. This review summarizes supporting demonstrating alterations bacterial fungal composition that may be associated HD. We focus on mechanisms dysbiosis compromise health, thus triggering neuroinflammatory responses, further highlight outcomes attempts modulate microbiota as therapeutic strategies Ultimately, we discuss dearth data need more longitudinal translational this nascent field. suggest future directions improve our association between microbes pathogenesis other ‘brain body disorders’.
Language: Английский
Citations
19
PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17061 - e17061
Published: March 13, 2024
Introduction An increasing number of studies have demonstrated that altered microbial diversity and function (such as metabolites), or ecological disorders, regulate bowel–brain axis involvement in the pathophysiologic processes Alzheimer’s disease (AD). The dysregulation microbes their metabolites can be a double-edged sword AD, presenting possibility microbiome-based treatment options. This review describes link between imbalances interactions AD modalities microbiota, potential interventions such prebiotics, probiotics, synbiotics, fecal microbiota transplantation, dietary complementary therapeutic strategies targeting pathogenesis progression. Survey methodology Articles from PubMed china.com on intestinal flora were summarized to analyze data conclusions carefully ensure comprehensiveness, completeness, accuracy this review. Conclusions Regulating gut balance upregulates neurotrophic factor expression, regulates microbiota-gut-brain (MGB) axis, suppresses inflammatory responses. Based emerging research, explored novel directions for future research clinical interventions, injecting new vitality into development.
Language: Английский
Citations
11
Food Bioengineering, Journal Year: 2024, Volume and Issue: 3(1), P. 126 - 147
Published: March 1, 2024
Abstract The establishment of a healthy microbiota, particularly during infancy, profoundly influences psychological health and neurological function through the gut‐brain axis. This review delves into intricate connections between probiotics, gut microbiome development, their impact on disorders. Biotics, live microorganisms with proven benefits, have emerged as promising intervention, critical developmental stages. Administering specific probiotic strains ( Lactobacillus species Bifidobacterium ) in infancy has shown promise preventing alleviating disorders, implications for well‐being. bidirectional communication along axis underscores potential probiotics influencing outcomes, ranging from anxiety to neurodevelopmental Additionally, this explores emerging food engineering techniques (microencapsulation, genome editing, fermentation, protein engineering, immobilization, etc.) employed preparing probiotic‐based foods, ensuring viability targeted release gastrointestinal tract.
Language: Английский
Citations
7
Metabolic Brain Disease, Journal Year: 2024, Volume and Issue: 39(5), P. 967 - 984
Published: June 7, 2024
Language: Английский
Citations
7
Journal of Huntington s Disease, Journal Year: 2024, Volume and Issue: 13(2), P. 133 - 147
Published: May 10, 2024
Huntingtin (HTT) protein is expressed in most cell lineages, and the toxicity of mutant HTT multiple organs may contribute to neurological psychiatric symptoms observed Huntington's disease (HD). The proteostasis neurotoxicity are influenced by intracellular milieu responses environmental signals. Recent research has highlighted a prominent role gut microbiota brain immune system development, aging, progression disorders. Several studies suggest that might disrupt homeostasis (known as dysbiosis) impact pathogenesis HD. Dysbiosis been HD patients, animal models it coincides with aggregation, abnormal behaviors, reduced lifespan. This review article aims highlight potential pathways within microbiota-gut-immune-central nervous (CNS) axis. Understanding functions Wild-Type (WT) these associated networks elucidate novel pathogenic pathways, identify biomarkers peripheral therapeutic targets for
Language: Английский
Citations
6
Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1144 - 1144
Published: July 3, 2024
Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes, including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations; however, higher concentrations, they can exacerbate HD disrupting glial–neuronal communication and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese, copper glial–neuron GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.
Language: Английский
Citations
6
Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(8)
Published: March 29, 2024
Abstract Cardiovascular diseases (CVDs) are a leading cause of global mortality and novel approaches for prevention management needed. The human gastrointestinal tract hosts diverse microbiota that is crucial in maintaining metabolic homeostasis. formulation effective probiotics, alone or combination, has been under discussion due to their impact on cardiovascular diseases. Probiotics have shown health positively. An imbalance the presence Firmicutes Bacteroidetes linked progression CVDs bile acid cholesterol metabolism. probiotics primarily help reduction plasma low‐density lipoprotein levels attenuation proinflammatory markers. These beneficial microorganisms contribute lowering produce essential short‐chain fatty acids. lipid‐regulating probiotic strains quite significant. However, only few tested potential efficacy, ambiguity exists regarding strain dosages, interactions with confounding factors, adverse effects. Hence, more comprehensive studies randomized trials needed understand mechanisms ensure health. This review assesses evidence highlights roles strain‐specific CVDs.
Language: Английский
Citations
4
Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122952 - 122952
Published: Aug. 9, 2024
The bidirectional regulation between the gut microbiota and brain, known as gut-brain axis, has received significant attention. myelin sheath, produced by oligodendrocytes or Schwann cells, is essential for efficient nervous signal transmission maintenance of brain function. Growing evidence shows that both oligodendrogenesis myelination are modulated its metabolites, when dysbiosis occurs, changes in composition and/or associated metabolites may impact developmental occurrence neurodevelopmental disabilities. Although link demyelinating disease such multiple sclerosis been extensively studied, our knowledge about role other myelin-related disorders, neurodegenerative diseases, limited. Mechanistically, microbiota-oligodendrocyte axis primarily mediated factors inflammation, vagus nerve, endocrine hormones, evidenced metagenomics, metabolomics, vagotomy, morphological molecular approaches. Treatments targeting this include probiotics, prebiotics, microbial herbal bioactive compounds, specific dietary management. In addition to commonly used approaches, viral vector-mediated tracing gene manipulation, integrated multiomics multicenter clinical trials will greatly promote mechanistic interventional studies ultimately, development new preventive therapeutic strategies against gut-oligodendrocyte axis-mediated impairments. Interestingly, recent findings showed can be induced hippocampal damage reversible myelin-targeted drugs, which provides insights into understanding how hippocampus-based functional impairment (such Alzheimer's disease) regulates peripheral homeostasis systemic disorders.
Language: Английский
Citations
4
Advanced Science, Journal Year: 2024, Volume and Issue: 11(38)
Published: Aug. 9, 2024
Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing its profound effects on occurrence development neurodegenerative diseases. No comprehensive review been conducted clarify triangular relationship involving axis potential for innovative therapies disorders. In light this, new perspective is aimed propose interplay between brain, gut, bone highlighting their dynamic communication in diseases, as they modulate including nervous, immune, endocrine, metabolic systems. Therapeutic strategies maintaining balance brain regulation, intestinal microbiota improving skeletal health, also explored. intricate interactions within pose challenge effective treatments can comprehensively target this system. Furthermore, safety these requires further evaluation. This offers novel insights prevention treatment which have important implications clinical practice patient well-being.
Language: Английский
Citations
4