Antioxidants and Redox Signaling,
Journal Year:
2020,
Volume and Issue:
33(3), P. 191 - 210
Published: March 7, 2020
Significance:
Accumulating
evidence
suggests
that
inflammation
is
a
major
contributor
in
the
pathogenesis
of
several
highly
prevalent,
but
also
rare,
neurological
diseases.
In
particular,
neurodegenerative
processes
Alzheimer's
disease
(AD),
vascular
dementia
(VAD),
Parkinson's
(PD),
and
multiple
sclerosis
(MS)
are
fueled
by
neuroinflammation,
which,
turn,
accompanied
parallel
systemic
immune
dysregulation.
This
cross-talk
between
periphery
brain
becomes
substantial
when
blood-brain
barrier
loses
its
integrity,
as
often
occurs
course
these
It
has
been
hypothesized
perpetual
bidirectional
flux
inflammatory
mediators
not
mere
"static"
collateral
effect
neurodegeneration,
represents
proactive
phenomenon
sparking
driving
neuropathological
processes.
However,
upstream/downstream
relationship
events
pathology
still
unclear.
Recent
Advances:
Solid
recent
clearly
metabolic
factors,
infections,
Microbiota
dysbiosis,
oxidative
stress
implicated,
although
to
different
extent,
development
Critical
Issues:
Here,
we
reviewed
most
solid
published
supporting
implication
axis
inflammation-neuroinflammation-neurodegeneration
AD,
VAD,
PD,
MS,
highlighting
possible
cause
putative
downstream
component
axis.
Future
Directions:
Reaching
definitive
clinical/epidemiological
appreciation
etiopathogenic
significance
connection
peripheral
neurologic
disorders
pivotal
since
it
could
open
novel
therapeutic
avenues
for
World Journal of Clinical Oncology,
Journal Year:
2023,
Volume and Issue:
14(4), P. 138 - 159
Published: April 20, 2023
Glioblastoma
remains
as
the
most
common
and
aggressive
malignant
brain
tumor,
standing
with
a
poor
prognosis
treatment
prospective.
Despite
standard
care,
such
surgical
resection
chemoradiation,
median
survival
rates
are
low.
In
this
regard,
immunotherapeutic
strategies
aim
to
become
more
attractive
for
glioblastoma,
considering
its
recent
advances
approaches.
review,
we
provide
an
overview
of
current
status
progress
in
immunotherapy
going
through
fundamental
knowledge
on
immune
targeting
promising
strategies,
Chimeric
antigen
receptor
T-Cell
therapy,
checkpoint
inhibitors,
cytokine-based
treatment,
oncolytic
virus
vaccine-based
techniques.
At
last,
it
is
discussed
innovative
methods
overcome
diverse
challenges,
future
perspectives
area.
Frontiers in Cellular Neuroscience,
Journal Year:
2019,
Volume and Issue:
13
Published: Sept. 20, 2019
The
blood-brain
barrier
(BBB)
helps
maintain
a
tightly
regulated
microenvironment
for
optimal
central
nervous
system
(CNS)
homeostasis
and
facilitates
communications
with
the
peripheral
circulation.
brain
endothelial
cells,
lining
brain's
vasculature,
close
interactions
surrounding
e.g.,
astrocytes,
pericytes
perivascular
macrophages.
This
function
critical
intercellular
crosstalk,
giving
rise
to
concept
of
neurovascular
unit
(NVU).
steady
appropriate
communication
between
all
components
NVU
is
essential
normal
CNS
function,
dysregulation
one
its
constituents
can
result
in
disease.
Among
different
regions,
along
vascular
tree,
cellular
composition
varies.
Therefore,
differential
cues
from
immediate
environment
affect
BBB
phenotype.
To
support
fluctuating
metabolic
functional
needs
underlying
neuropil,
specialized
heterogeneity
required.
achieved
by
variances
expression
transporters,
receptors,
adhesion
molecules.
mini-review
will
take
you
on
journey
through
evolving
concepts
BBB,
beyond.
Exploring
classical
experiments
leading
new
approaches
allow
us
understand
that
not
merely
static
separation
periphery
but
closely
interactive
entity.
We
discuss
shifting
paradigms,
ultimately
aim
address
importance
regard
within
NVU,
touch
implications
neuropathologies.
Antioxidants and Redox Signaling,
Journal Year:
2020,
Volume and Issue:
33(3), P. 191 - 210
Published: March 7, 2020
Significance:
Accumulating
evidence
suggests
that
inflammation
is
a
major
contributor
in
the
pathogenesis
of
several
highly
prevalent,
but
also
rare,
neurological
diseases.
In
particular,
neurodegenerative
processes
Alzheimer's
disease
(AD),
vascular
dementia
(VAD),
Parkinson's
(PD),
and
multiple
sclerosis
(MS)
are
fueled
by
neuroinflammation,
which,
turn,
accompanied
parallel
systemic
immune
dysregulation.
This
cross-talk
between
periphery
brain
becomes
substantial
when
blood-brain
barrier
loses
its
integrity,
as
often
occurs
course
these
It
has
been
hypothesized
perpetual
bidirectional
flux
inflammatory
mediators
not
mere
"static"
collateral
effect
neurodegeneration,
represents
proactive
phenomenon
sparking
driving
neuropathological
processes.
However,
upstream/downstream
relationship
events
pathology
still
unclear.
Recent
Advances:
Solid
recent
clearly
metabolic
factors,
infections,
Microbiota
dysbiosis,
oxidative
stress
implicated,
although
to
different
extent,
development
Critical
Issues:
Here,
we
reviewed
most
solid
published
supporting
implication
axis
inflammation-neuroinflammation-neurodegeneration
AD,
VAD,
PD,
MS,
highlighting
possible
cause
putative
downstream
component
axis.
Future
Directions:
Reaching
definitive
clinical/epidemiological
appreciation
etiopathogenic
significance
connection
peripheral
neurologic
disorders
pivotal
since
it
could
open
novel
therapeutic
avenues
for
