Immunopathology of herpes simplex virus‐associated neuroinflammation: Unveiling the mysteries DOI
Md Sadique Hussain, Gaurav Gupta,

Vijaya Paul Samuel

et al.

Reviews in Medical Virology, Journal Year: 2023, Volume and Issue: 34(1)

Published: Nov. 20, 2023

The immunopathology of herpes simplex virus (HSV)-associated neuroinflammation is a captivating and intricate field study within the scientific community. HSV, renowned for its latent infection capability, gives rise to spectrum neurological expressions, ranging from mild symptoms severe encephalitis. enigmatic interplay between host's immune responses profoundly shapes outcome these infections. This review delves into multifaceted reactions triggered by HSV neural tissues, intricately encompassing innate adaptive immunity. Furthermore, this analysis delicate equilibrium defence potential immunopathology-induced damage. It meticulously dissects roles diverse cells, cytokines, chemokines, unravelling intricacies modulation subsequent effects. By exploring HSV's manipulation exploitation mechanisms, endeavours unveil enigmas surrounding HSV-associated neuroinflammation. comprehensive understanding enhances our grasp viral pathogenesis holds promise pioneering therapeutic strategies designed mitigate ramifications

Language: Английский

Th17 cells and inflammation in neurological disorders: Possible mechanisms of action DOI Creative Commons
Yajun Shi, Bin Wei, Lingjun Li

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 22, 2022

Neurological disorders (NDs) are one of the leading causes global death. A sustained neuroinflammatory response has been reported to be associated with pathogenesis multiple NDs, including Parkinson’s disease (PD), sclerosis (MS), Alzheimer’s (AD), amyotrophic lateral (ALS), and major depressive disorder (MDD). Accumulating evidence shows that recruitment abundant lymphocytes in central nervous system may contribute promoting development progress inflammation neurological disorders. As subset T lymphocytes, CD4 + cells have a critical impact on helper (Th) 17 is most studied Th subpopulations produces cytokines (e.g., IL-17A, IL-23, IL-21, IL-6, IFN-γ), abnormal excessive activation microglia other immune cell types. All these factors involved several However, possible mechanisms Th17 their immunopathology abovementioned not clarified completely. This review will summarize by which encephalitogenic inflammatory related strongly chronic neuroinflammation, thus perpetuating neurodegenerative processes NDs. Finally, potential therapeutic prospects NDs also discussed.

Language: Английский

Citations

72
A Decade of Dedication: Pioneering Perspectives on Neurological Diseases and Mental Illnesses DOI Creative Commons
Masaru Tanaka, László Vécsei

Biomedicines, Journal Year: 2024, Volume and Issue: 12(5), P. 1083 - 1083

Published: May 13, 2024

Welcome to

Language: Английский

Citations

18
Potential neurological effects of severe COVID-19 infection DOI Open Access
Domenico Nuzzo, Pasquale Picone

Neuroscience Research, Journal Year: 2020, Volume and Issue: 158, P. 1 - 5

Published: July 3, 2020

Language: Английский

Citations

74
COVID-19: dealing with a potential risk factor for chronic neurological disorders DOI Creative Commons
Tommaso Schirinzi, Doriana Landi, Claudio Liguori

et al.

Journal of Neurology, Journal Year: 2020, Volume and Issue: 268(4), P. 1171 - 1178

Published: Aug. 27, 2020

Abstract SARS-CoV2 infection is responsible for a complex clinical syndrome, named Coronavirus Disease 2019 (COVID-19), whose main consequences are severe pneumonia and acute respiratory distress syndrome. Occurrence of subacute neurological manifestations (encephalitis, stroke, headache, seizures, Guillain–Barrè syndrome) increasingly reported in patients with COVID-19. Moreover, immunopathology tissue colonization the gut central nervous system, systemic inflammatory response during COVID-19 may potentially trigger chronic autoimmune neurodegenerative disorders. Specifically, Parkinson’s disease, multiple sclerosis narcolepsy present several pathogenic mechanisms that can be hypothetically initiated by susceptible individuals. In this short narrative review, we summarize evidence supporting rationale investigating as risk factor these disorders, suggest opportunity to perform future serology when diagnosing

Language: Английский

Citations

74
Neuroinflammation: A Signature or a Cause of Epilepsy? DOI Open Access
Enrico Pracucci, Vinoshene Pillai, Didi Lamers

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6981 - 6981

Published: June 29, 2021

Epilepsy can be both a primary pathology and secondary effect of many neurological conditions. Many papers show that neuroinflammation is product epilepsy, in pathological conditions characterized by neuroinflammation, there higher probability to develop epilepsy. However, the bidirectional mechanism reciprocal interaction between epilepsy remains fully understood. Here, we attempt explore discuss relationship inflammation some paradigmatic systemic disorders associated with In particular, have chosen one representative form for each its actual known etiologies. A better understanding mechanistic link would important improve subject-based therapies, prophylaxis treatment

Language: Английский

Citations

73
Nanotechnology-Abetted Astaxanthin Formulations in Multimodel Therapeutic and Biomedical Applications DOI Creative Commons
Zohreh Jafari, Ashkan Bigham,

Sahar Sadeghi

et al.

Journal of Medicinal Chemistry, Journal Year: 2021, Volume and Issue: 65(1), P. 2 - 36

Published: Dec. 17, 2021

Astaxanthin (AXT) is one of the most important fat-soluble carotenoids that have abundant and diverse therapeutic applications namely in liver disease, cardiovascular cancer treatment, protection nervous system, skin eyes against UV radiation, boosting immune system. However, due to its intrinsic reactivity, it chemically unstable, therefore, design production processes for this compound need be precisely formulated. Nanoencapsulation widely applied protect AXT degradation during digestion storage, thus improving physicochemical properties effects. Nanocarriers are delivery systems with many advantages─ease surface modification, biocompatibility, targeted drug release. This review discusses technological advancement nanocarriers through brain, eyes, skin, emphasis on benefits, limitations, efficiency practice.

Language: Английский

Citations

57
Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders DOI Creative Commons

Mohamed Elbandy

Molecules, Journal Year: 2022, Volume and Issue: 28(1), P. 2 - 2

Published: Dec. 20, 2022

Functional foods include enhanced, enriched, fortified, or whole that impart health benefits beyond their nutritional value, particularly when consumed as part of a varied diet on regular basis at effective levels. Marine sources can serve the various healthy and numerous functional food ingredients with biological effects be derived from these sources. Microalgae, macroalgae, crustaceans, fungi, bacteria fish, fish by-products are most common marine provide many potential including phenolic compounds, proteins peptides, polysaccharides. Neuroinflammation is closely linked initiation progression neurodegenerative diseases, Alzheimer's disease, Huntington's Parkinson's disease. Activation astrocytes microglia defense mechanism brain to counter damaged tissues detrimental pathogens, wherein chronic activation triggers neuroinflammation further exacerbate induce neurodegeneration. Currently, available therapeutic agents only symptomatic relief disorders no therapies stop slow down advancement Thereffore, natural compounds exert protective effect against have potential. Numerous chemical bioactive fatty acids, pigments, alkaloids, polysaccharides, already been isolated show anti-inflammatory properties, which in treatment prevention neuroinflammatory disorders. The marine-derived neurological covered this review.

Language: Английский

Citations

47
Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives DOI Creative Commons
Claire Shaw, Matthias Hess, Bart C. Weimer

et al.

Microorganisms, Journal Year: 2023, Volume and Issue: 11(7), P. 1825 - 1825

Published: July 17, 2023

The gut microbiome provides the host access to otherwise indigestible nutrients, which are often further metabolized by into bioactive components. can also shift balance of host-produced compounds, may alter health. One precursor metabolites is essential aromatic amino acid tryptophan. Tryptophan mostly shunted kynurenine pathway but primary metabolite for serotonin production and bacterial indole pathway. Balance between tryptophan-derived crucial neurological homeostasis metabolic imbalance trigger or exacerbate diseases. Alzheimer's, depression, schizophrenia have been linked diverging levels anthranilic, kynurenic, quinolinic acid. Anthranilic from collective metabolism plays a complex important role in systemic Although anthranilic its products great importance host-microbe interaction health, literature examining mechanistic relationships microbial production, regulation, diseases scarce at times conflicting. This narrative review an overview current understanding acid's health disease, with particular focus on contribution microbiome, gut-brain axis, involvement three major tryptophan pathways.

Language: Английский

Citations

31
Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials DOI Creative Commons
Maryam Ghasemi, Elham Roshandel, Mozhdeh Mohammadian

et al.

Stem Cell Research & Therapy, Journal Year: 2023, Volume and Issue: 14(1)

Published: May 4, 2023

Abstract Background Over the past few years, mesenchymal stromal cells (MSCs) have attracted a great deal of scientific attention owing to their promising results in treatment incurable diseases. However, there are several concerns about possible side effects after direct cell transplantation, including host immune response, time-consuming culture procedures, and dependence quality on donor, which limit application MSCs clinical trials. On other hand, it is well accepted that beneficial mediated by secretome rather than replacement. MSC refers variety bioactive molecules involved different biological processes, specifically neuro-regeneration. Main body Due limited ability central nervous system compensate for neuronal loss relieve disease progress, stem products may be used as potential cure disorders. In present study, therapeutic were reviewed discussed mechanisms three most prevalent disorders, namely Alzheimer's disease, multiple sclerosis, Parkinson's disease. The current work aimed help discover new medicine mentioned complications. Conclusion use MSC-derived secretomes diseases has encouraging results, so can considered option no been introduced far.

Language: Английский

Citations

29
Neuroinflammation and Epilepsy: From Pathophysiology to Therapies Based on Repurposing Drugs DOI Open Access
Pascual Sanz, Teresa Rubio, María Adelaida García-Gimeno

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4161 - 4161

Published: April 9, 2024

Neuroinflammation and epilepsy are different pathologies, but, in some cases, they so closely related that the activation of one pathologies leads to development other. In this work, we discuss three main cell types involved neuroinflammation, namely (i) reactive astrocytes, (ii) activated microglia, infiltration (iii) peripheral immune cells central nervous system. Then, how neuroinflammation interconnected describe use repurposing drugs with anti-inflammatory properties have been shown a beneficial effect models. This review reinforces idea compounds designed alleviate seizures need target not only caused by astrocytes microglia but also interaction these infiltrated cells.

Language: Английский

Citations

17