Corticosteroids for the prevention of bronchopulmonary dysplasia in preterm infants: a network meta-analysis DOI Creative Commons
Linan Zeng, Jinhui Tian, Fujian Song

et al.

Archives of Disease in Childhood Fetal & Neonatal, Journal Year: 2018, Volume and Issue: 103(6), P. F506 - F511

Published: Feb. 23, 2018

Objective To determine the comparative efficacy and safety of corticosteroids in prevention bronchopulmonary dysplasia (BPD) preterm infants. Study design We systematically searched PubMed, EMBASE Cochrane Library. Two reviewers independently selected randomised controlled trials (RCTs) postnatal A Bayesian network meta-analysis subgroup analyses were performed. Results included 47 RCTs with 6747 participants. The use dexamethasone at either high dose or low decreased risk BPD (OR 0.29, 95% credible interval (CrI) 0.14 to 0.52; OR 0.58, CrI 0.39 0.76, respectively). High-dose was more effective than hydrocortisone, beclomethasone low-dose dexamethasone. Early long-term 0.11, 0.02 0.4; 0.37, 0.16 0.67, There no statistically significant differences cerebral palsy (CP) between different corticosteroids. However, high-dose ranked lower placebo other regimens terms CP. Subgroup indicated budesonide associated a extremely birthweight infants 0.60, 0.36 0.93). Conclusions Dexamethasone can reduce Of regimens, aggressive initiation seems beneficial, while combination should be avoided because possible adverse neurodevelopmental outcome. inhaled need further evaluated large-scale follow-ups.

Language: Английский

Developmental and evolutionary dynamics of cis-regulatory elements in mouse cerebellar cells DOI
Ioannis Sarropoulos, Mari Sepp, Robert Frömel

et al.

Science, Journal Year: 2021, Volume and Issue: 373(6558)

Published: July 29, 2021

The cerebellum reveals its genetic programs Gene-regulatory networks govern the development of organs. Sarropoulos et al . analyzed mouse cerebellar in context gene-regulatory networks. Single nuclear profiles analyzing chromatin accessibility about 90,000 cells revealed diversity progenitor and guiding cellular differentiation. footsteps evolution were apparent varying constraints on different cell types. —PJH

Language: Английский

Citations

66
A Focus on the Cerebellum: From Embryogenesis to an Age-Related Clinical Perspective DOI Creative Commons
Greta Amore,

Giulia Spoto,

Antonio Ieni

et al.

Frontiers in Systems Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: April 9, 2021

The cerebellum and its functional multiplicity heterogeneity have been objects of curiosity interest since ancient times, giving rise to the urge reveal complexity. Since first hypothesis cerebellar mere role in motor tuning coordination, much more has continuously discovered about cerebellum's circuitry functioning throughout centuries, leading currently accepted knowledge prominent involvement cognitive, social, behavioral areas. Particularly childhood, may subserve several age-dependent functions, which might be compromised Central Nervous System pathologies. Overall, damage produce numerous signs symptoms determine a wide variety neuropsychiatric impairments already during evolutive age. Therefore, an early assessment children would desirable address prompt diagnosis proper intervention months life. Here we provide overview cerebellum, retracing morphology, histogenesis, physiological finally outlining typical atypical development patterns dysfunctions.

Language: Английский

Citations

61
Protracted development of motor cortex constrains rich interpretations of infant cognition DOI Creative Commons
Mark S. Blumberg,

Karen E. Adolph

Trends in Cognitive Sciences, Journal Year: 2023, Volume and Issue: 27(3), P. 233 - 245

Published: Jan. 20, 2023

Language: Английский

Citations

43
A Potential Role for Neuroinflammation in ADHD DOI

Daniela Vázquez-González,

Sonia Carreón-Trujillo, Lourdes Álvarez‐Arellano

et al.

Advances in experimental medicine and biology, Journal Year: 2023, Volume and Issue: unknown, P. 327 - 356

Published: Jan. 1, 2023

Language: Английский

Citations

25
Little brain, little minds: The big role of the cerebellum in social development DOI Creative Commons
Ingrid R. Olson, Linda J. Hoffman, Katie R. Jobson

et al.

Developmental Cognitive Neuroscience, Journal Year: 2023, Volume and Issue: 60, P. 101238 - 101238

Published: March 27, 2023

Seminal work in the 1990's found alterations cerebellum of individuals with social disorders including autism spectrum disorder and schizophrenia. In neurotypical populations, distinct portions posterior are consistently activated fMRI studies cognition it has been hypothesized that plays an essential role cognition, particularly theory mind. Here we review lesion literature find effect cerebellar damage on is strongly linked to age insult, dramatic impairments observed after prenatal strong deficits childhood damage, mild inconsistent following adult cerebellum. To explain developmental gradient, propose early life, forward model dominates computations. The learns uses errors help build schemas our interpersonal worlds. Subsequently, argue once these have built up, inverse model, which foundation automatic processing, becomes dominant. We provide suggestions for how test this, also outline directions future research.

Language: Английский

Citations

25
A seat at the (language) table: incorporating the cerebellum into frameworks for language processing DOI Creative Commons
Amanda LeBel, Anila M. D’Mello

Current Opinion in Behavioral Sciences, Journal Year: 2023, Volume and Issue: 53, P. 101310 - 101310

Published: Sept. 15, 2023

Language: Английский

Citations

25
Population-wide cerebellar growth models of children and adolescents DOI Creative Commons
Carolin Gaiser, Rick van der Vliet, Augustijn A. A. de Boer

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 18, 2024

Abstract In the past, cerebellum has been best known for its crucial role in motor function. However, increasingly more findings highlight importance of cerebellar contributions cognitive functions and neurodevelopment. Using a total 7240 neuroimaging scans from 4862 individuals, we describe provide detailed, openly available models development childhood adolescence (age range: 6–17 years), an important time period brain onset neuropsychiatric disorders. Next to traditionally used anatomical parcellation cerebellum, generated growth based on recently proposed functional parcellation. both, find anterior-posterior gradient mirroring age-related improvements underlying behavior function, which is analogous cerebral maturation patterns offers evidence directly related cerebello-cortical developmental trajectories. Finally, illustrate how current approach can be detect abnormalities clinical samples.

Language: Английский

Citations

14
Fetal brain MRI atlases and datasets: A review DOI Creative Commons
Tommaso Ciceri, Luca Casartelli, Florian Montano

et al.

NeuroImage, Journal Year: 2024, Volume and Issue: 292, P. 120603 - 120603

Published: April 1, 2024

Fetal brain development is a complex process involving different stages of growth and organization which are crucial for the circuits neural connections. atlases labeled datasets promising tools to investigate prenatal development. They support identification atypical patterns, providing insights into potential early signs clinical conditions. In nutshell, imaging post-processing via modern cutting-edge field that will significantly contribute advancement our understanding fetal this work, we first provide terminological clarification specific terms (i.e., "brain template" atlas"), highlighting potentially misleading interpretations related an inconsistent use in literature. We discuss major structures neurodevelopmental milestones characterizing ontogenesis. Our main contribution systematic review datasets: reviewed 18 3 datasets, reporting their public links when available. also tangentially focused on clinical, research, ethical implications neuroimaging. Prenatal should be considered priority by scientific community maximize developing brain.

Language: Английский

Citations

14
Altered lipid homeostasis is associated with cerebellar neurodegeneration in SNX14 deficiency DOI Creative Commons

Yijing Zhou,

Vanessa Sánchez,

Peining Xu

et al.

JCI Insight, Journal Year: 2024, Volume and Issue: 9(10)

Published: April 16, 2024

Dysregulated lipid homeostasis is emerging as a potential cause of neurodegenerative disorders. However, evidence errors in pathogenic mechanism neurodegeneration remains limited. Here, we show that cerebellar caused by Sorting Nexin 14 (SNX14) deficiency associated with defects. Recent studies indicate SNX14 an inter-organelle transfer protein regulates transport, droplet (LD) biogenesis, and fatty acid desaturation, suggesting human belongs to expanding class disorders altered cellular homeostasis. To test this hypothesis, generated mouse model recapitulates at genetic phenotypic level. We demonstrate Purkinje cells (PCs) are selectively vulnerable while forebrain regions preserve their neuronal content. Ultrastructure lipidomic reveal widespread storage metabolism defects deficient mice. pre-degenerating cerebella unique accumulation acylcarnitines depletion triglycerides. Furthermore, LD content telolysosome enlargement PCs, suggest lipotoxicity deficiency. Our work shows selective vulnerability provides for future therapeutic studies.

Language: Английский

Citations

9
Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging DOI Creative Commons
Anna Rappe, Helena Vihinen, Fumi Suomi

et al.

The EMBO Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Mitophagy neutralizes mitochondrial damage, thereby preventing cellular dysfunction and apoptosis. Defects in mitophagy have been strongly implicated age-related neurodegenerative disorders such as Parkinson’s Alzheimer’s disease. While decreases throughout the lifespan of short-lived model organisms, it remains unknown whether a decline occurs aging mammalian brain—a question fundamental importance for understanding cell type- region-specific susceptibility to neurodegeneration. Here, we define longitudinal dynamics basal macroautophagy across neuronal non-neuronal types within intact mouse brain vivo. Quantitative profiling reporter cohorts from young geriatric ages reveals cell- tissue-specific alterations between distinct subregions populations, including dopaminergic neurons, cerebellar Purkinje cells, astrocytes, microglia interneurons. We also find that healthy is hallmarked by dynamic accumulation differentially acidified lysosomes several neural subsets. Our findings argue against any widespread mitophagic activity, instead demonstrating fluctuations trajectory, with strong implications ongoing theragnostic development.

Language: Английский

Citations

9