Inflammation Research, Journal Year: 2023, Volume and Issue: 72(12), P. 2127 - 2144
Published: Oct. 30, 2023
Language: Английский
Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(11), P. 1620 - 1653
Published: Nov. 1, 2022
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic, maternally inherited, energy-transforming, biosynthetic, and signaling organelles that actively transduce biological information. We argue the processor cell, together with nucleus other they constitute mitochondrial information processing system (MIPS). In a three-step process, (1) sense respond to both endogenous environmental inputs through morphological functional remodeling; (2) integrate network-based physical interactions diffusion mechanisms; (3) produce output signals tune functions systemically regulate physiology. This input-to-output transformation allows metabolic, biochemical, neuroendocrine, local or systemic enhance organismal adaptation. An explicit focus on signal transduction emphasizes role communication in biology. framework also opens new avenues understand how mediate inter-organ processes underlying human health.
Language: Английский
Citations
330
eLife, Journal Year: 2022, Volume and Issue: 11
Published: Nov. 16, 2022
Learning from experience depends at least in part on changes neuronal connections. We present the largest map of connectivity to date between cortical neurons a defined type (layer 2/3 [L2/3] pyramidal cells mouse primary visual cortex), which was enabled by automated analysis serial section electron microscopy images with improved handling image defects (250 × 140 90 μm3 volume). used identify constraints learning algorithms employed cortex. Previous studies modeled continuum synapse sizes log-normal distribution. A is consistent most neural network models learning, synaptic strength continuously graded analog variable. Here, we show that size, when restricted synapses L2/3 cells, well sum binary variable and an drawn Two sharing same presynaptic postsynaptic are known be correlated size. variables two highly correlated, while not. Binary variation could outcome Hebbian or other plasticity rule depending activity signals relatively uniform across arbors, may dominated influences such as spontaneous dynamical fluctuations. discuss implications for longstanding hypothesis activity-dependent switches bistable states.
Language: Английский
Citations
75
Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(9), P. 586 - 600
Published: Aug. 3, 2023
Language: Английский
Citations
51
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)
Published: Sept. 23, 2023
Optoelectronic memristors (OMs) have emerged as a promising optoelectronic Neuromorphic computing paradigm, opening up new opportunities for neurosynaptic devices and systems. These OMs possess range of desirable features including minimal crosstalk, high bandwidth, low power consumption, zero latency, the ability to replicate crucial neurological functions such vision optical memory. By incorporating large-scale parallel synaptic structures, are anticipated greatly enhance high-performance low-power in-memory computing, effectively overcoming limitations von Neumann bottleneck. However, progress in this field necessitates comprehensive understanding suitable structures techniques integrating low-dimensional materials into integrated circuit platforms. This review aims offer overview fundamental performance, mechanisms, design applications, integration roadmap memristors. establishing connections between materials, multilayer memristor units, monolithic circuits, seeks provide insights emerging technologies future prospects that expected drive innovation widespread adoption near future.
Language: Английский
Citations
51
Cell, Journal Year: 2023, Volume and Issue: 186(11), P. 2475 - 2491.e22
Published: May 1, 2023
Holistic understanding of physio-pathological processes requires noninvasive 3D imaging in deep tissue across multiple spatial and temporal scales to link diverse transient subcellular behaviors with long-term physiogenesis. Despite broad applications two-photon microscopy (TPM), there remains an inevitable tradeoff among spatiotemporal resolution, volumes, durations due the point-scanning scheme, accumulated phototoxicity, optical aberrations. Here, we harnessed concept synthetic aperture radar TPM achieve aberration-corrected dynamics at a millisecond scale for over 100,000 large volumes tissue, three orders magnitude reduction photobleaching. With its advantages, identified direct intercellular communications through migrasome generation following traumatic brain injury, visualized formation process germinal center mouse lymph node, characterized heterogeneous cellular states visual cortex, opening up horizon intravital understand organizations functions biological systems holistic level.
Language: Английский
Citations
47
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: Feb. 16, 2024
Abstract Serotonin (5-HT) imbalances in the developing prefrontal cortex (PFC) are linked to long-term behavioral deficits. However, synaptic mechanisms underlying 5-HT-mediated PFC development unknown. We found that chemogenetic suppression and enhancement of 5-HT release during first two postnatal weeks decreased increased density strength excitatory spine synapses, respectively, on layer 2/3 pyramidal neurons mice. single spines induced structural functional potentiation (LTP), requiring both 5-HT2A 5-HT7 receptor signals, a glutamatergic activity-independent manner. Notably, LTP-inducing stimuli survival newly formed ( ≥ 6 h) via Gα s activation. Chronic treatment mice with fluoxetine, selective serotonin-reuptake inhibitor, weeks, but not third week development, synapses. The effect fluoxetine alterations vivo was abolished by antagonists. Our data describe molecular basis 5-HT-dependent plasticity at level early development.
Language: Английский
Citations
21
Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)
Published: May 26, 2022
Abstract Postoperative cognitive dysfunction (POCD) is common and associated with poor outcome. Neural circuit involvement in POCD unknown. Lateral habenula (LHb) that regulates coping depression‐like behaviors after aversive stimuli activated by surgery the previous study. Here, LHb ventral tegmental area (VTA) are presented. VTA known to receive projections from project prefrontal cortex hippocampus. Direct chemogenetic inhibition of or damaging attenuates surgery‐induced learning memory impairment, N ‐methyl‐ d ‐aspartate (NMDA) receptor activation, endoplasmic reticulum stress, inflammatory responses cell injury VTA, activation rostromedial nucleus, an intermediate station connect VTA. preserves dendritic spine density Retrograde via its attenuated observed. induced Inhibition NMDA receptors, dopamine synthesis, stress reduced responses, These results suggest activates LHb‐VTA neural circuit, which contributes neuropathological changes brain. novel findings represent initial evidence for effects.
Language: Английский
Citations
46
Nature Neuroscience, Journal Year: 2022, Volume and Issue: 25(11), P. 1458 - 1469
Published: Nov. 1, 2022
Language: Английский
Citations
45
Materials Horizons, Journal Year: 2024, Volume and Issue: 11(12), P. 2886 - 2897
Published: Jan. 1, 2024
The ever-growing information data has driven the pursuit of advanced BFCO thin-film synapses, which have multifunctionality, adjustable plasticity, unique photoelectric response, and optical memory effects detected by femtosecond lasers.
Language: Английский
Citations
10
Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
9