Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1150 - 1150
Published: April 5, 2023
Arthritis
is
the
inflammation
and
tenderness
of
joints
because
some
metabolic,
infectious,
or
constitutional
reasons.
Existing
arthritis
treatments
help
in
controlling
arthritic
flares,
but
more
advancement
required
to
cure
meticulously.
Biomimetic
nanomedicine
represents
an
exceptional
biocompatible
treatment
by
minimizing
toxic
effect
eliminating
boundaries
current
therapeutics.
Various
intracellular
extracellular
pathways
can
be
targeted
mimicking
surface,
shape,
movement
biological
system
form
a
bioinspired
biomimetic
drug
delivery
system.
Different
cell-membrane-coated
systems,
extracellular-vesicle-based
platelets-based
systems
represent
emerging
efficient
class
therapeutics
treat
arthritis.
The
cell
membrane
from
various
cells
such
as
RBC,
platelets,
macrophage
cells,
NK
isolated
utilized
mimic
environment.
Extracellular
vesicles
patients
used
diagnostic
tools,
plasma
MSCs-derived
therapeutic
target
for
guide
nanomedicines
site
hiding
them
surveillance
immune
Nanomedicines
functionalized
using
ligand
stimuli-responsive
reinforce
their
efficacy
minimize
off-target
effects.
This
review
expounds
on
functionalization
targets
treatment,
discusses
challenges
clinical
translation
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 21, 2024
Abstract
Inflammation-associated
diseases
encompass
a
range
of
infectious
and
non-infectious
inflammatory
diseases,
which
continuously
pose
one
the
most
serious
threats
to
human
health,
attributed
factors
such
as
emergence
new
pathogens,
increasing
drug
resistance,
changes
in
living
environments
lifestyles,
aging
population.
Despite
rapid
advancements
mechanistic
research
development
for
these
current
treatments
often
have
limited
efficacy
notable
side
effects,
necessitating
more
effective
targeted
anti-inflammatory
therapies.
In
recent
years,
nanotechnology
has
provided
crucial
technological
support
prevention,
treatment,
detection
inflammation-associated
diseases.
Various
types
nanoparticles
(NPs)
play
significant
roles,
serving
vaccine
vehicles
enhance
immunogenicity
carriers
improve
targeting
bioavailability.
NPs
can
also
directly
combat
pathogens
inflammation.
addition,
facilitated
biosensors
pathogen
imaging
techniques
This
review
categorizes
characterizes
different
NPs,
summarizes
their
applications
It
discusses
challenges
associated
with
clinical
translation
this
field
explores
latest
developments
prospects.
conclusion,
opens
up
possibilities
comprehensive
management
Micromachines,
Journal Year:
2023,
Volume and Issue:
14(9), P. 1786 - 1786
Published: Sept. 18, 2023
Exploring
bio-inspired
nanomaterials
(BINMs)
and
incorporating
them
into
micro/nanodevices
represent
a
significant
development
in
biomedical
applications.
Nanomaterials,
engineered
to
imitate
biological
structures
processes,
exhibit
distinctive
attributes
such
as
exceptional
biocompatibility,
multifunctionality,
unparalleled
versatility.
The
utilization
of
BINMs
demonstrates
potential
diverse
domains
micro/nanodevices,
encompassing
biosensors,
targeted
drug
delivery
systems,
advanced
tissue
engineering
constructs.
This
article
thoroughly
examines
the
various
BINMs,
including
those
originating
from
proteins,
DNA,
biomimetic
polymers.
Significant
attention
is
directed
toward
these
entities
subsequent
ramifications
that
arise.
review
explores
biomimicry’s
structure–function
correlations.
Synthesis
mosaics
include
bioprocesses,
biomolecules,
natural
structures.
These
nanomaterials’
interfaces
use
functionalization
geometric
adaptations,
transforming
delivery,
nanobiosensing,
organ-on-chip
cancer-on-chip
models,
wound
healing
dressing
mats,
antimicrobial
surfaces.
It
provides
an
in-depth
analysis
existing
challenges
proposes
prospective
strategies
improve
efficiency,
performance,
reliability
devices.
Furthermore,
this
study
offers
forward-thinking
viewpoint
highlighting
avenues
for
future
exploration
advancement.
objective
effectively
utilize
maximize
application
progression
thereby
propelling
rapidly
developing
field
its
promising
future.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 7, 2024
Neutrophils
are
the
most
abundant
white
blood
cells
in
circulation
and
act
as
first
line
of
defense
against
infections.
Increasing
evidence
suggests
that
neutrophils
possess
heterogeneous
phenotypes
functional
plasticity
human
health
diseases,
including
cancer.
play
multifaceted
roles
cancer
development
progression,
an
N1/N2
paradigm
is
proposed,
where
N1
exert
anti-tumor
properties
while
N2
display
tumor-supportive
immune-suppressive
functions.
Selective
activation
beneficial
neutrophil
population
targeted
inhibition
or
re-polarization
tumor-promoting
has
shown
important
potential
tumor
therapy.
In
addition,
due
to
natural
inflammation-responsive
physical
barrier-crossing
abilities,
their
derivatives
(membranes
extracellular
vesicles
(EVs))
regarded
advanced
drug
delivery
carriers
for
enhanced
targeting
improved
therapeutic
efficacy.
this
review,
recent
advances
engineering
remodeling
microenvironment
(TME)
comprehensively
presented.
This
review
will
provide
a
broad
understanding
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(4), P. 531 - 531
Published: April 12, 2024
Nanoparticle-based
drug
delivery
systems
hold
promise
for
cancer
treatment
by
enhancing
the
solubility
and
stability
of
anti-tumor
drugs.
Nonetheless,
challenges
inadequate
targeting
limited
biocompatibility
persist.
In
recent
years,
cell
membrane
nano-biomimetic
have
emerged
as
a
focal
point
research
development,
due
to
their
exceptional
traits,
including
precise
targeting,
low
toxicity,
good
biocompatibility.
This
review
outlines
categorization
advantages
bionic
nano-delivery
systems,
provides
an
introduction
preparation
methods,
assesses
applications
in
treatment,
chemotherapy,
gene
therapy,
immunotherapy,
photodynamic
photothermal
combination
therapy.
Notably,
delves
into
application
various
identifies
opportunities
future
advancement.
Embracing
membrane-coated
biomimetic
nanoparticles
presents
novel
unparalleled
avenue
personalized
tumor
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
35, P. 150 - 166
Published: Jan. 27, 2024
Neutrophils
have
recently
emerged
as
promising
carriers
for
drug
delivery
due
to
their
unique
properties
including
rapid
response
toward
inflammation,
chemotaxis,
and
transmigration.
When
integrated
with
nanotechnology
that
has
enormous
advantages
in
improving
treatment
efficacy
reducing
side
effects,
neutrophil-based
nano-drug
systems
expanded
the
repertoire
of
nanoparticles
employed
precise
therapeutic
interventions
by
either
coating
membranes,
loading
inside
living
cells,
or
engineering
chimeric
antigen
receptor
(CAR)-neutrophils.
These
neutrophil-inspired
therapies
shown
superior
biocompatibility,
targeting
ability,
robustness.
In
this
review,
we
summarized
benefits
combining
neutrophils
nanotechnologies,
design
principles
underlying
mechanisms,
various
applications
disease
treatments.
The
challenges
prospects
were
also
discussed.
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(1), P. 100885 - 100885
Published: Feb. 1, 2024
In
this
study,
a
multifunctional
liposomal
polydopamine
nanoparticle
(MPM@Lipo)
was
designed
to
combine
chemotherapy,
photothermal
therapy
(PTT)
and
oxygen
enrichment
clear
hyperproliferating
inflammatory
cells
improve
the
hypoxic
microenvironment
for
rheumatoid
arthritis
(RA)
treatment.
MPM@Lipo
significantly
scavenged
intracellular
reactive
species
relieved
joint
hypoxia,
thus
contributing
repolarization
of
M1
macrophages
into
M2
phenotype.
Furthermore,
could
accumulate
at
joints,
inhibit
production
factors,
protect
cartilage
in
vivo,
effectively
alleviating
RA
progression
rat
adjuvant-induced
model.
Moreover,
upon
laser
irradiation,
can
elevate
temperature
not
only
obliterate
excessively
proliferating
but
also
accelerate
methotrexate
oxygen,
resulting
excellent
treatment
effects.
Overall,
use
synergistic
chemotherapy/PTT/oxygen
treat
is
powerful
potential
strategy.
Drug Discovery Today,
Journal Year:
2024,
Volume and Issue:
29(6), P. 103991 - 103991
Published: April 23, 2024
The
development
of
vaccines
has
had
a
crucial
role
in
preventing
and
controlling
infectious
diseases
on
global
scale.
Innovative
formulations
biomimetic
inspired
by
natural
defense
mechanisms
combine
long-term
antigen
stability,
immunogenicity,
targeted
delivery
with
sustained
release.
Types
nanoparticle
(NP)
include
bacterial
outer
membrane
vesicles
(OMVs),
cell
membrane-decorated
NPs,
liposomes,
exosomes.
These
approaches
have
shown
potential
for
cancer
immunotherapy,
antibacterial
antiviral
applications.
Despite
current
challenges,
nanovaccines
immense
to
transform
disease
prevention
treatment,
promising
therapeutic
the
future.
In
this
review,
we
highlight
recent
advances
vaccine
design,
action,
clinical
applications,
emphasizing
their
personalized
medicine,
drug
delivery,
immunomodulation.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
209, P. 115316 - 115316
Published: April 23, 2024
Neutrophils
play
an
essential
role
as
'first
responders'
in
the
immune
response,
necessitating
many
immune-modulating
capabilities.
Chronic,
unresolved
inflammation
is
heavily
implicated
progression
and
tissue-degrading
effects
of
autoimmune
disease.
modulate
disease
pathogenesis
by
interacting
with
inflammatory
autoreactive
cells
through
effector
functions,
including
signaling,
degranulation,
neutrophil
extracellular
traps
(NETs)
release.
Since
current
gold
standard
systemic
glucocorticoid
administration
has
drawbacks
side
effects,
targeting
neutrophils
autoimmunity
provides
a
new
approach
to
developing
therapeutics.
Nanoparticles
enable
specific
cell
types
controlled
release
loaded
drug
cargo.
Thus,
leveraging
nanoparticle
properties
interactions
exciting
direction
toward
novel
therapies
for
diseases.
Additionally,
recent
work
utilized
design
targeted
particles
delivery
into
previously
inaccessible
areas.
Here,
we
outline
nanoparticle-based
strategies
activity
autoimmunity,
various
formulations
neutrophil-derived
targeting.
