Cells,
Journal Year:
2024,
Volume and Issue:
13(6), P. 512 - 512
Published: March 14, 2024
Hypoxia-inducible
factor-1
(HIF-1)
is
a
heterodimer
transcription
factor
composed
of
an
alpha
and
beta
subunit.
HIF-1α
master
regulator
cellular
response
to
hypoxia
by
activating
the
genes
that
facilitate
metabolic
adaptation
hypoxia.
Since
chondrocytes
in
mature
articular
cartilage
reside
hypoxic
environment,
plays
important
role
chondrogenesis
physiological
lifecycle
cartilage.
Accumulating
evidence
suggests
interactions
between
HIF
pathways
circadian
clock.
The
clock
emerging
both
developing
chondrocytes.
However,
how
rhythm
established
during
early
steps
formation
through
what
signaling
it
promotes
healthy
chondrocyte
phenotype
still
not
entirely
known.
This
narrative
review
aims
deliver
concise
analysis
existing
understanding
dynamic
interplay
molecular
chondrocytes,
states
health
disease,
while
also
incorporating
creative
interpretations.
We
explore
diverse
hypotheses
regarding
intricate
among
these
propose
relevant
therapeutic
strategies
for
disorders
such
as
osteoarthritis.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(28)
Published: May 8, 2024
Abstract
3D‐printed
cell‐laden
hydrogels
as
tissue
constructs
show
great
promise
in
generating
living
tissues
for
medicine.
Currently,
the
maturation
of
into
remains
challenge,
since
commonly
used
struggle
to
provide
an
ideal
microenvironment
seeded
cells.
In
this
study,
a
cell‐adaptable
nanocolloidal
hydrogel
is
created
3D
printing
maturable
constructs.
The
composed
interconnected
nanoparticles,
which
prepared
by
self‐assembly
and
subsequent
photocrosslinking
gelatin
methacryloyl
solutions.
Cells
can
get
enough
space
grow
migrate
within
through
squeezing
flexible
networks.
Meanwhile,
nanostructure
promote
cells
proliferate
produce
matrix
proteins
mechanotransduction.
Using
digital
light
process‐based
technology,
it
rapidly
customize
cartilage
After
implantation,
these
efficiently
matured
articular
defect
repair
ear
reconstruction
vivo.
using
shows
potential
future
clinical
applications.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101034 - 101034
Published: March 25, 2024
Osteoarthritis
(OA)
is
characterized
by
progressive
and
irreversible
damage
to
the
articular
cartilage
a
consecutive
inflammatory
response.
However,
majority
of
clinical
drugs
for
OA
treatment
only
alleviate
symptoms
without
addressing
fundamental
pathology.
To
mitigate
this
issue,
we
developed
an
inflammation-responsive
carrier
encapsulated
bioactive
material,
namely,
LDH@TAGel.
The
LDH@TAGel
was
designed
with
anti-inflammatory
antioxidative
abilities,
aiming
directly
address
pathology
damage.
In
particular,
LDH
confirmed
restore
ECM
secretion
function
damaged
chondrocytes
attenuate
expression
catabolic
matrix
metalloproteinases
(Mmps).
While
TAGel
showed
antioxidant
properties
scavenging
ROS
directly.
vitro
evaluation
revealed
that
could
protect
from
inflammation-induced
oxidative
stress
apoptosis
via
Nrf2/Keap1
system
Pi3k-Akt
pathway.
vivo
experiments
demonstrated
alleviated
degeneration
degradation
induced
anterior
cruciate
ligament
transection
(ACLT).
OARSI
scores
indicating
severity
decreased
significantly
after
three
weeks
intervention.
Moreover,
IVIS
image
enhances
controlled
release
in
manner
can
be
customized
according
OA,
allowing
adaptive,
precise
treatment.
summary,
novel
design
effectively
alleviates
underlying
pathological
causes
OA-related
has
emerged
as
promising
biomaterial
cause-targeted
therapies.
Cells,
Journal Year:
2024,
Volume and Issue:
13(6), P. 512 - 512
Published: March 14, 2024
Hypoxia-inducible
factor-1
(HIF-1)
is
a
heterodimer
transcription
factor
composed
of
an
alpha
and
beta
subunit.
HIF-1α
master
regulator
cellular
response
to
hypoxia
by
activating
the
genes
that
facilitate
metabolic
adaptation
hypoxia.
Since
chondrocytes
in
mature
articular
cartilage
reside
hypoxic
environment,
plays
important
role
chondrogenesis
physiological
lifecycle
cartilage.
Accumulating
evidence
suggests
interactions
between
HIF
pathways
circadian
clock.
The
clock
emerging
both
developing
chondrocytes.
However,
how
rhythm
established
during
early
steps
formation
through
what
signaling
it
promotes
healthy
chondrocyte
phenotype
still
not
entirely
known.
This
narrative
review
aims
deliver
concise
analysis
existing
understanding
dynamic
interplay
molecular
chondrocytes,
states
health
disease,
while
also
incorporating
creative
interpretations.
We
explore
diverse
hypotheses
regarding
intricate
among
these
propose
relevant
therapeutic
strategies
for
disorders
such
as
osteoarthritis.
